{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T17:55:40Z","timestamp":1649094940328},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3-4","license":[{"start":{"date-parts":[[1992,3,1]],"date-time":"1992-03-01T00:00:00Z","timestamp":699408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Agents and Actions"],"published-print":{"date-parts":[[1992,3]]},"DOI":"10.1007\/bf01997497","type":"journal-article","created":{"date-parts":[[2005,8,4]],"date-time":"2005-08-04T20:49:11Z","timestamp":1123188551000},"page":"179-184","source":"Crossref","is-referenced-by-count":2,"title":["Dimaprit \u2014 induced neurotoxicity"],"prefix":"10.1007","volume":"35","author":[{"given":"R. L.","family":"Swaab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Battles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Bruner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"Hough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF01997497_CR1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01964878","volume":"7","author":"M. E. Parsons","year":"1977","unstructured":"M. E. Parsons, D. A. A. Owen, C. R. Ganellin and G. J. Durant,Dimaprit-[S-[3-(N,N-dimethylamino)propyl]isothiourea] \u2014 a highly specific histamine H 2-receptor agonist. Part 1. Pharmacology. Agents and Actions7, 31\u201337 (1977).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF01964879","volume":"7","author":"G. J. Durant","year":"1977","unstructured":"G. J. Durant, C. R. Granellin and M. E. Parsons,Dimaprit, [S-[3-(N,N-dimethylamino)propyl]isotiourea \u2014 a highly specific histamine H 2 receptor agonist. Part 2. Structure-activity considerations. Agents and Actions7, 39\u201343 (1977).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/B978-0-7236-0589-8.50008-9","volume-title":"Pharmacology of histamine receptors","author":"C. R. Ganellin","year":"1982","unstructured":"C. R. Ganellin,Chemistry and structure-activity relationships of drugs acting at histamine receptors. InPharmacology of histamine receptors. (Eds. C. R. Ganellin and M. E. Parsons) pp. 10\u2013102. John Wright & Sons, Ltd., Bristol 1982."},{"key":"BF01997497_CR4","first-page":"148","volume-title":"Handbook of neurochemistry","author":"L. B. Hough","year":"1984","unstructured":"L. B. Hough and J. P. Green,Histamine and its receptors in the nervous system. InHandbook of neurochemistry (2nd ed.) (Ed. A. Lajtha) pp. 148\u2013211, Plenum Press, New York 1984.","edition":"2nd ed."},{"key":"BF01997497_CR5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.ne.09.030186.001233","volume":"9","author":"G. D. Prell","year":"1986","unstructured":"G. D. Prell and J. P. Green,Histamine as a neuroregulator. Annu. Rev. Neurosci.9, 209\u2013254 (1986).","journal-title":"Annu. Rev. Neurosci."},{"key":"BF01997497_CR6","first-page":"469","volume-title":"Progress in neurobiology","author":"L. B. Hough","year":"1988","unstructured":"L. B. Hough,Cellular localization and possible functions for brain histamine: recent progress. InProgress in neurobiology (Eds. G. A. Kerkut and J. W. Phillis) pp. 469\u2013505. Pergamon Press, Oxford 1988."},{"key":"BF01997497_CR7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF02142554","volume":"23","author":"C. Netti","year":"1988","unstructured":"C. Netti, F. Guidobono, V. Sibilia, I. Villa, E. Cazzamalli and A. Pecile,Central effects of histamine H 2-receptor agonists and antagonists on nociception in the rat. Agents and Actions23, 247\u2013249 (1988).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000137972","volume":"28","author":"C. Netti","year":"1984","unstructured":"C. Netti, R. Bossa, I. Galatulas, V. Sibilia and A. Pecile,Antinociceptive effect of centrally administered cimetidine and dimaprit in the rat. Pharmacology28, 262\u2013267 (1984).","journal-title":"Pharmacology"},{"key":"BF01997497_CR9","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0028-3908(79)90023-6","volume":"18","author":"Z. J. Nowak","year":"1979","unstructured":"Z. J. Nowak, E. Ferrario and U. Lebrecht,Dimaprit-induced hypothermia in normal rats: its attenuation by cimetidine and by tricyclic antidepressant drugs. Neuropharmacology18, 783\u2013789 (1979).","journal-title":"Neuropharmacology"},{"key":"BF01997497_CR10","first-page":"431","volume":"27","author":"G. Nistico","year":"1980","unstructured":"G. Nistico, D. Rotiroti, A. De Sarro, F. Naccari and J. D. Stephenson,Central effects of histamine and H 1 ad H2 receptors agonists and antagonists after intraventricular infusion in fowls. Res. Commun. Chem. Pathol. Pharmacol.27, 431\u2013450 (1980).","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"BF01997497_CR11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0028-3908(80)90069-6","volume":"19","author":"A. Pilc","year":"1980","unstructured":"A. Pilc and J. Z. Nowak,The influence of 4-methylhistamine, an agonist of histamine H 2 receptors on body temperature in rats. Neuropharmacology19, 773\u2013775 (1980).","journal-title":"Neuropharmacology"},{"key":"BF01997497_CR12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0028-3908(82)90209-X","volume":"21","author":"O. Colboc","year":"1982","unstructured":"O. Colboc, P. Protais and J. Costentin,Histamine-induced rise in core temperature of chloral-anaesthetized rats: mediation by H 2-receptors located in the preopticus area of hypothalamus. Neuropharmacol.21, 45\u201350 (1982).","journal-title":"Neuropharmacol."},{"key":"BF01997497_CR13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0149-7634(85)90023-5","volume":"9","author":"W. G. Clark","year":"1985","unstructured":"W. G. Clark and J. M. Lipton,Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents: II. Neurosci. Biobehav. Rev.9, 479\u2013552 (1985).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"BF01997497_CR14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/BF01988027","volume":"18","author":"J. Bugajski","year":"1986","unstructured":"J. Bugajski, A. Gadek and B. Cetera,The interaction of ethanol with central histaminergic stimulation of the pituitary-adrenocortical and hyperlipemic activity. Agents and Actions18, 226\u2013230 (1986).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR15","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/BF02074685","volume":"20","author":"A. Gadek","year":"1987","unstructured":"A. Gadek, B. Cetera and J. Bugajski,Central histaminergic stimulation of corticosterone and hyperlipemic responses after chronic ethanol consumption in rats. Agents and Actions20, 258\u2013261 (1987).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF02074684","volume":"20","author":"J. Bugajski","year":"1987","unstructured":"J. Bugajski and A. Gadek,Hyperlipemic responses induced by centrally administered histamine H 1- and H2-receptor agonists in rats. Agents and Actions20, 255\u2013257 (1987).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/10641967809068607","volume":"1","author":"P. E. Hicks","year":"1978","unstructured":"P. E. Hicks,Central cardiovascular actions of histamine in rats: involvement of histamine H 2-receptors. Clin. Exp. Hypertens.1, 251\u2013265 (1978).","journal-title":"Clin. Exp. Hypertens."},{"key":"BF01997497_CR18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF02024204","volume":"10","author":"L. Tuomisto","year":"1980","unstructured":"L. Tuomisto and L. Eriksson,Cardiovascular and behavioural changes after i.c.v. infusions of histamine and agonists in conscious goat. Agents and Actions10, 165\u2013166 (1980).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF01991483","volume":"11","author":"A. Philippu","year":"1981","unstructured":"A. Philippu and K. Wiedemann,Hypothalamic superfusion with histamine agonists and antagonists modifies the pressor response to hypothalamic stimulation. Agents and Actions11, 143\u2013144 (1981).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1474-8673.1981.tb00502.x","volume":"1","author":"A. Philippu","year":"1981","unstructured":"A. Philippu and K. Wiedemann,Hypothalamic superfusion with histamine agonists and antagonists modifies the pressor response to hypothalamic stimulation. J. Auton. Pharmacol.1, 111\u2013117 (1981).","journal-title":"J. Auton. Pharmacol."},{"key":"BF01997497_CR21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0014-2999(87)90707-2","volume":"136","author":"A. R. Granata","year":"1987","unstructured":"A. R. Granata and D. J. Reis,Hypotension and bradycardia elicited by histamine into the C1 area of the rostral ventrolateral medulla. Eur. J. Pharmacol.136, 157\u2013162 (1987).","journal-title":"Eur. J. Pharmacol."},{"key":"BF01997497_CR22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0028-3908(82)90158-7","volume":"21","author":"I. Paakkari","year":"1982","unstructured":"I. Paakkari and H. Karppanen,Analeptic effect of centrally administered histamine H 2-receptor agonist dimaprit but not impromidine in urethane-anesthetized rats. Neuropharmacology21, 171\u2013178 (1982).","journal-title":"Neuropharmacology"},{"key":"BF01997497_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01262953","volume":"66","author":"J. M. Monti","year":"1986","unstructured":"J. M. Monti, T. Pellejero and H. Jantos,Effects of H 1-and H2-histamine receptor agonists and antagonists on sleep and wakefulness in the rat. J. Neural Transm.66, 1\u201311 (1986).","journal-title":"J. Neural Transm."},{"key":"BF01997497_CR24","first-page":"44","volume":"33","author":"M. N. Gannon","year":"1988","unstructured":"M. N. Gannon and L. B. Hough,Histamine receptors coupled to [3H]cAMP accumulation in brain: pharmacological characterization in a vesicular preparation of guinea pig cortex. Mol. Pharmacol.33, 44\u201350 (1988).","journal-title":"Mol. Pharmacol."},{"key":"BF01997497_CR25","first-page":"38","volume":"33","author":"M. Garbarg","year":"1988","unstructured":"M. Garbarg and J. C. Schwartz,Synergism between histamine H 1- and H2-receptors in the cAMP response in guinea pig brain slices: effects of phorbol esters and calcium. Mol. Pharmacol.33, 38\u201343 (1988).","journal-title":"Mol. Pharmacol."},{"key":"BF01997497_CR26","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1471-4159.1988.tb03043.x","volume":"50","author":"K. Ozawa","year":"1988","unstructured":"K. Ozawa and T. Segawa,Histamine increases phospholipid methylation and H 2-receptor-adenylate cyclase coupling in rat brain. J. Neurochem.50, 1551\u20131558 (1988).","journal-title":"J. Neurochem."},{"key":"BF01997497_CR27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF02222219","volume":"27","author":"J. Z. Nowak","year":"1989","unstructured":"J. Z. Nowak, B. Sek and B. Szkiel,Histamine-mediated regulation of cAMP levels and inositol phosphate metabolism in isolated rabbit retina. Agents and Actions27, 131\u2013134 (1989).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR28","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/0024-3205(83)90023-1","volume":"33","author":"J. Bugajski","year":"1983","unstructured":"J. Bugajski and Z. Janusz,Central histaminergic stimulation of pituitary-adrenocortical response in the rat. Life. Sci.33, 1179\u20131189 (1983).","journal-title":"Life. Sci."},{"key":"BF01997497_CR29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00236637","volume":"52","author":"A. O. Donoso","year":"1983","unstructured":"A. O. Donoso and M. B. Zarate,Release of prolactin and luteinizing hormone by histamine agonists in ovariectomized, steroid-treated rats under ether anesthesia. Exp. Brain. Res.52, 277\u2013280 (1983).","journal-title":"Exp. Brain. Res."},{"key":"BF01997497_CR30","first-page":"33","volume":"8","author":"G. DiRenzo","year":"1986","unstructured":"G. DiRenzo, V. Basile, S. Amoroso, G. Lombardi and L. Annunziato,Effect of dimaprit, a selective histamine H 2-receptor agonist, on prolactin secretion in male rats. Neuroendocrinol. Lett.8, 33\u201339 (1986).","journal-title":"Neuroendocrinol. Lett."},{"key":"BF01997497_CR31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF01244351","volume":"69","author":"G. F. Renzo Di","year":"1987","unstructured":"G. F. Di Renzo, V. Basile, S. Amoroso, M. Taglialatela, F. Maurano and L. Annunziato,Possible inhibitory role of histamine H 2 receptors in the control of basal TSH secretion in male rats: studies with dimaprit, a selective H 2 receptor agonist. J. Neural. Transm.69, 313\u2013318 (1987).","journal-title":"J. Neural. Transm."},{"key":"BF01997497_CR32","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1159\/000125059","volume":"48","author":"U. Knigge","year":"1988","unstructured":"U. Knigge, I. Sleimann, S. Matzen and J. Warberg,Histaminergic regulation of prolactin secretion: involvement of serotoninergic neurons. Neuroendocrinology48, 527\u2013533 (1988).","journal-title":"Neuroendocrinology"},{"key":"BF01997497_CR33","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1530\/acta.0.1190488","volume":"119","author":"C. Netti","year":"1988","unstructured":"C. Netti, V. Sibilia, F. Guidobono, I. Villa, P. Franco and A. Pecile,Further evidence that brain histamine H 2 receptors are stimulatory in the control of prolactin in the rat. Acta Endocrinol. (Copenh.)119, 488\u2013492 (1988).","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"BF01997497_CR34","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF02142556","volume":"23","author":"A. Gadek Michalska","year":"1988","unstructured":"A. Gadek Michalska and J. Bugajski,Naloxone antagonizes a central histaminergic stimulation of corticosterone secretion in rats. Agents and Actions23, 254\u2013256 (1988).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR35","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1530\/acta.0.1190312","volume":"119","author":"U. Knigge","year":"1988","unstructured":"U. Knigge, F. W. Bach, S. Matzen, P. Bang and J. Warberg,Effect of histamine on the secretion of pro-opiomelanocortin derived peptides in rats. Acta Endocrinol. (Copenh.)119, 312\u2013319 (1988).","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"BF01997497_CR36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF02024205","volume":"10","author":"J. Z. Nowak","year":"1980","unstructured":"J. Z. Nowak, B. Bielkiewicz, U. Lebrecht, A. Kordecka and C. Maslinski,Effects of the histamine H 2-receptor agonists dimaprit and 4-methylhistamine on the central noradrenaline and serotonin system. Agents and Actions10, 167\u2013172 (1980).","journal-title":"Agents and Actions"},{"key":"BF01997497_CR37","first-page":"44","volume":"249","author":"P. Blandina","year":"1989","unstructured":"P. Blandina, P. J. Knott, L. K. Leung and J. P. Green,Stimulation of histamine H 2 receptor in rat hypothalamus releases endogenous norepinephrine. J. Pharmacol. Exp. Ther.249, 44\u201351 (1989).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BF01997497_CR38","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0091-3057(79)90336-8","volume":"10","author":"L. A. Crane","year":"1979","unstructured":"L. A. Crane and S. D. Glick,Simple cannula for repeated intracerebral drug administration in rats. Phamacol. Biochem. Behav.10, 799\u2013800 (1979).","journal-title":"Phamacol. Biochem. Behav."},{"key":"BF01997497_CR39","volume-title":"The rat brain in stereotaxic coordinates","author":"G. Paxinos","year":"1982","unstructured":"G. Paxinos and C. Watson,The rat brain in stereotaxic coordinates. Academic Press, Sydney 1982."},{"key":"BF01997497_CR40","first-page":"65","volume-title":"Methods in psychobiology","author":"R. D. Myers","year":"1971","unstructured":"R. D. Myers,General laboratory procedures. InMethods in psychobiology. (Ed. R. D. Myers) pp. 65. Academic Press, London 1971."},{"key":"BF01997497_CR41","first-page":"359","volume-title":"BMDP statistical software manual","author":"W. J. Dixon","year":"1985","unstructured":"W. J. Dixon,BMDP statistical software manual. pp. 359. University of California Press, Berkley 1985."},{"key":"BF01997497_CR42","volume-title":"Neurological urology: physiology of micturition, its neurological disorders and sequelae","author":"E. Bors","year":"1971","unstructured":"E. Bors and A. E. Comarr,Neurological urology: physiology of micturition, its neurological disorders and sequelae. University Park Press, Baltimore 1971."},{"key":"BF01997497_CR43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1476-5381.1988.tb11406.x","volume":"93","author":"C. R. Calcutt","year":"1988","unstructured":"C. R. Calcutt, C. R. Ganellin, R. Griffiths, B. K. Leigh, J. P. Maguire, R. C. Mitchell, M. E. Mylek, M. E. Parsons, I. R. Smith and R. C. Young,Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H 2-receptor antagonist. Br. J. Pharmacol.93, 69\u201378 (1988).","journal-title":"Br. J. Pharmacol."},{"key":"BF01997497_CR44","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/ddr.430030611","volume":"3","author":"M. C. Klein","year":"1983","unstructured":"M. C. Klein, J. J. Poulakos, S. B. Gertner and A. Siegel,The neurotoxcity of homodimaprit (SKF-91488): sites of action assessed by the [14C]2-deoxyglucose technique. Drug Devel. Res.3, 581\u2013587 (1983).","journal-title":"Drug Devel. Res."},{"key":"BF01997497_CR45","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0028-3908(84)90148-5","volume":"23","author":"P. J. Gatti","year":"1984","unstructured":"P. J. Gatti and S. B. Gertner,The effect of intrahypothalamic injection of homodimaprit on blood pressure. Neuropharmacology23, 663\u2013670 (1984).","journal-title":"Neuropharmacology"},{"key":"BF01997497_CR46","first-page":"893","volume":"26","author":"L. Petit","year":"1990","unstructured":"L. Petit, F. Leperchey and E. Fournier,Experimental toxicology of the isothioureas. Poumon C\u0153ur26, 893\u2013894 (1990).","journal-title":"Poumon C\u0153ur"}],"container-title":["Agents and Actions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01997497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01997497\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01997497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T11:00:06Z","timestamp":1557831606000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01997497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":46,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["BF01997497"],"URL":"https:\/\/doi.org\/10.1007\/bf01997497","relation":{},"ISSN":["0065-4299","1420-908X"],"issn-type":[{"value":"0065-4299","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}