{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:21:34Z","timestamp":1791249694242,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1978,12,1]],"date-time":"1978-12-01T00:00:00Z","timestamp":281318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Agents and Actions"],"published-print":{"date-parts":[[1978,12]]},"DOI":"10.1007\/bf01998888","type":"journal-article","created":{"date-parts":[[2005,8,11]],"date-time":"2005-08-11T03:37:41Z","timestamp":1123731461000},"page":"587-605","source":"Crossref","is-referenced-by-count":44,"title":["Structure-activity relationships of non-steroid anti-inflammatory drugs 1. Gastric ulcerogenic activity"],"prefix":"10.1007","volume":"8","author":[{"given":"K. D.","family":"Rainsford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF01998888_CR1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.me.23.020172.001501","volume":"23","author":"R. Menguy","year":"1972","unstructured":"R. Menguy,Acute Gastric Mucosal Bleeding, Ann. Rev. Med.23, 297\u2013312 (1972).","journal-title":"Ann. Rev. Med."},{"key":"BF01998888_CR2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2165\/00003495-197611010-00003","volume":"11","author":"A.R. Cooke","year":"1976","unstructured":"A.R. Cooke,Drugs and Gastric Damage, Drugs11, 36\u201344 (1976).","journal-title":"Drugs"},{"key":"BF01998888_CR3","series-title":"An International Symposium","first-page":"217","volume-title":"Salicylates","author":"K.W. Anderson","year":"1963","unstructured":"K.W. Anderson,Some Biochemical and Physiological Aspects of Salicylate-Induced Gastric Lesions in Laboratory Animals, in: Salicylates,An International Symposium. (Eds. A.St.J. Dixon, B.K. Martin, M.J.H. Smith and P.H.N. Wood; Churchill, London, 1963), pp. 217\u2013223."},{"key":"BF01998888_CR4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.2042-7158.1976.tb02807.x","volume":"28","author":"K.D. Rainsford","year":"1976","unstructured":"K.D. Rainsford andM.W. Whitehouse,Gastric Irritancy of Aspirin and its Congeners: Anti-Inflammatory Activity Without this Side-Effect, J. Pharm. Pharmac.28, 599\u2013601 (1976).","journal-title":"J. Pharm. Pharmac."},{"key":"BF01998888_CR5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02205240","volume":"5","author":"K.D. Rainsford","year":"1975","unstructured":"K.D. Rainsford,The Biochemical Pathology of Aspirin-Induced Gastric Damage, Agents and Actions5, 326\u2013344 (1975).","journal-title":"Agents and Actions"},{"key":"BF01998888_CR6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF01972694","volume":"5","author":"K.D. Rainsford","year":"1975","unstructured":"K.D. Rainsford,A Synergistic Interaction between Aspirin, or other Non-Steroidal Anti-Inflammatory Drugs, and Stress Which Produces Severe Gastric Damage in Rats and Pigs, Agents and Actions5, 553\u2013558 (1975).","journal-title":"Agents and Actions"},{"key":"BF01998888_CR7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF02111132","volume":"7","author":"K.D. Rainsford","year":"1977","unstructured":"K.D. Rainsford,The Comparative Gastric Ulcerogenic Activities of Non-Steroid Anti-Inflammatory Drugs, Agents and Actions7, 573\u2013577 (1977).","journal-title":"Agents and Actions"},{"key":"BF01998888_CR8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/00359157770700S602","volume":"Suppl. 6","author":"K.D. Rainsford","year":"1977","unstructured":"K.D. Rainsford,Comparative Studies of Gastric Ulcerogenesis by Non-Steroid Anti-Inflammatory Drugs: Effects of Fenclofenac, Proc. Roy. Soc. Med. Suppl.6, 4\u201310 (1977).","journal-title":"Proc. Roy. Soc. Med."},{"key":"BF01998888_CR9","first-page":"121","volume":"2","author":"K.D. Rainsford","year":"1977","unstructured":"K.D. Rainsford,Gastrointestinal Damage from Aspirin and Non-Steroidal Anti-Inflammatory Drugs: Thoughts for Safer Therapy from Biochemical Studies, Drugs Exptl. Clin. Res.2, 121\u2013132 (1977).","journal-title":"Drugs Exptl. Clin. Res."},{"key":"BF01998888_CR10","unstructured":"K.D. Rainsford,Gastrointestinal and other Side-Effects from the Use of Aspirin and Related Drugs: Biochemical Studies on the Mechanisms of Gastrotoxicity, inProceedings of the Symposium on Aspirin and Related Drugs: Their Actions and Uses. (Eds. K.D. Rainsford, K. Brune and M.W. Whitehouse; Agents and Actions, Suppl. 1, pp. 59\u201370, 1977)."},{"key":"BF01998888_CR11","first-page":"215","volume":"58","author":"K.D. Rainsford","year":"1977","unstructured":"K.D. Rainsford,Aspirin and Gastric Ulceration: Light and Electronmicroscopic Observations in a Model of Aspirin Plus Stress-Induced Ulcerogenesis, Br. J. exp. Path.58, 215\u2013219 (1977).","journal-title":"Br. J. exp. Path."},{"key":"BF01998888_CR12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF01072696","volume":"23","author":"K.D. Rainsford","year":"1978","unstructured":"K.D. Rainsford,The Role of Aspirin in Gastric Ulceration: Some Factors Involved in the Development of Gastric Mucosal Damage Induced by Aspirin in Rats Exposed to Various Stress Conditions, Am. J. dig. Dis.23, 521\u2013530 (1978).","journal-title":"Am. J. dig. Dis."},{"key":"BF01998888_CR13","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1136\/gut.16.7.514","volume":"16","author":"K.D. Rainsford","year":"1975","unstructured":"K.D. Rainsford,Electronmicroscopic Observations on the Effects of Orally Administered Aspirin and Aspirin-Bicarbonate Mixtures on the Development of Gastric Mucosal Damage in the Rat, Gut16, 514\u2013527 (1975).","journal-title":"Gut"},{"key":"BF01998888_CR14","first-page":"40","volume":"2","author":"K.D. Rainsford","year":"1975","unstructured":"K.D. Rainsford,The Relationship between Distribution of Salicylates in the Gastrointestinal Tract and Blood and Development of Gastric Damage after Oral Administration of Aspirin and Aspirin Bicarbonate Mixtures in Rats, Clin. exp. Pharmacol. Physiol.2, 40\u201341 (1975).","journal-title":"Clin. exp. Pharmacol. Physiol."},{"key":"BF01998888_CR15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0024-3205(77)90517-3","volume":"21","author":"K.D. Rainsford","year":"1977","unstructured":"K.D. Rainsford andM.W. Whitehouse,Non-Steroid Anti-Inflammatory Drugs: Combined Assay for Anti-Edemic Potency and Gastric Ulcerogenesis in the Same Animal, Life Sciences21, 371\u2013378 (1977).","journal-title":"Life Sciences"},{"key":"BF01998888_CR16","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1021\/jm00269a003","volume":"16","author":"C. Hansch","year":"1973","unstructured":"C. Hansch, A. Leo, S.H. Unger, K.H. Kim, D. Nikaitani andE.J. Lien,\u2018Aromatic\u2019 Substituent Constants for Structure-Activity Correlations, J. Med. Chem.16, 1207\u20131216 (1973).","journal-title":"J. Med. Chem."},{"key":"BF01998888_CR17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1039\/qr9662000075","volume":"20","author":"G.B. Barlin","year":"1966","unstructured":"G.B. Barlin andD.D. Perrin,Prediction of the Strength of Organic Acids, Quarterly Reviews20, 75\u2013101 (1966).","journal-title":"Quarterly Reviews"},{"key":"BF01998888_CR18","first-page":"271","volume-title":"Drug. Design.","author":"C. Hansch","year":"1971","unstructured":"C. Hansch,Quantitative Structure-Activity Relationships in Drug Design, in:Drug. Design. (Ed. E.J. Ari\u00ebns; Academic Press, New York, 1971), pp. 271\u2013342."},{"key":"BF01998888_CR19","series-title":"Int. Union of Pure Appl. Chem.","volume-title":"Dissociation Constants of Organic Acids in Aqueous Solution","author":"G. Kort\u00fcm","year":"1961","unstructured":"G. Kort\u00fcm,W. Vogel andK. Andrusson,Dissociation Constants of Organic Acids in Aqueous Solution, Int. Union of Pure Appl. Chem. (Butterworths, London, 1961)."},{"key":"BF01998888_CR20","unstructured":"Personal Communication, Dr.J.W. James, Nicholas Research Institute."},{"key":"BF01998888_CR21","volume-title":"Ionization Constants of Acids and Bases","author":"A. Albert","year":"1962","unstructured":"A. Albert andE.P. Serjeant,Ionization Constants of Acids and Bases. (Wiley, New York, 1962)."},{"key":"BF01998888_CR22","first-page":"528","volume":"120","author":"L.S. Schanker","year":"1957","unstructured":"L.S. Schanker, P.A. Shore, B.B. Brodie andC.A.M. Hogben,Absorption of Drugs from the Stomach I. The Rat, J. Pharm. exp. Therap.120, 528\u2013539 (1957).","journal-title":"J. Pharm. exp. Therap."},{"key":"BF01998888_CR23","unstructured":"Chemical Society Special Reports Nos. 17 and 25Stability Constants."},{"key":"BF01998888_CR24","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/0006-2952(70)90118-8","volume":"19","author":"C. Hansch","year":"1970","unstructured":"C. Hansch andK.N. von Kaulla,Fibrinolytic Congeners of Benzoic and Salicylic Acid. A Mathematical Analysis of Correlation between Structure and Activity, Biochem. Pharmac.19, 2193\u20132220 (1970).","journal-title":"Biochem. Pharmac."},{"key":"BF01998888_CR25","first-page":"613","volume":"10","author":"P. Moser","year":"1975","unstructured":"P. Moser, K. J\u00e4kel, P. Krupp, R. Menass\u00e9 andA. Sallmann,Structure-Activity Relations of Analogs of Phenylbutazone, Eur. J. Med. Chem.10, 613\u2013617 (1975).","journal-title":"Eur. J. Med. Chem."},{"key":"BF01998888_CR26","first-page":"361","volume":"119","author":"P.A. Shore","year":"1957","unstructured":"P.A. Shore, B.B. Brodie andC.A.M. Hogben,The Gastric Secretion of Drugs: A pH Partition Hypothesis, J. Pharm. exp. Therap.119, 361\u2013369 (1957).","journal-title":"J. Pharm. exp. Therap."},{"key":"BF01998888_CR27","doi-asserted-by":"crossref","first-page":"881","DOI":"10.5694\/j.1326-5377.1976.tb141133.x","volume":"1","author":"K.D. Rainsford","year":"1976","unstructured":"K.D. Rainsford andK. Brune,Role of the Parietal Cell in Gastric Damage Induced by Aspirin and Related Drugs: Implications for Safer Therapy, Med. J. Aust.1, 881\u2013883 (1976).","journal-title":"Med. J. Aust."},{"key":"BF01998888_CR28","first-page":"35","volume":"2","author":"J.W. Horodniak","year":"1977","unstructured":"J.W. Horodniak, E.D. Matz, D.T. Walz, R.D. Cramer III, B.M. Sutton, C.E. Berkhoff, J.E. Zarembo andA.D. Bender,Inhibition of Prostaglandin Synthetase and Carrageenin-Induced Edema by Analogs of Flufenamic Acid, Drugs, expt. Clin. Res.2, 35\u201345 (1977).","journal-title":"Drugs, expt. Clin. Res."},{"key":"BF01998888_CR29","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1021\/jm00234a011","volume":"19","author":"S.A. Lang","year":"1979","unstructured":"S.A. Lang, B.D. Johnson, E. Cohen, A.E. Sloboda andE. Greenblatt,Aryl s-Tetrazines with Anti-inflammatory Activity, J. Med. Chem.19, 1404\u20131409 (1979).","journal-title":"J. Med. Chem."},{"key":"BF01998888_CR30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/jm00249a016","volume":"17","author":"H. Terada","year":"1974","unstructured":"H. Terada, S. Muraoka andT. Fujita,Structure-Activity Relationships of Fenamic Acids, J. Med. Chem.17, 330\u2013334 (1974).","journal-title":"J. Med. Chem."},{"key":"BF01998888_CR31","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1021\/ja00995a006","volume":"89","author":"A.R. Fesht","year":"1967","unstructured":"A.R. Fesht andA.J. Kirby,Structure and Mechanism in Intramolecular Catalysis. The Hydrolysis of Substituted Aspirins, J. Am. Chem. Soc.89, 4853\u20134857 (1967).","journal-title":"J. Am. Chem. Soc."},{"key":"BF01998888_CR32","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/0006-2952(77)90155-1","volume":"26","author":"K. Brune","year":"1977","unstructured":"K. Brune, A. Schweitzer andH. Eckert,Parietal Cells Trap Salicylates during Absorption, Biochem. Pharmac.26, 1735\u20131740 (1977).","journal-title":"Biochem. Pharmac."},{"key":"BF01998888_CR33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF01891969","volume":"40","author":"K.D. Rainsford","year":"1978","unstructured":"K.D. Rainsford andK. Brune,Selective Cytotoxic Actions of Aspirin on Parietal Cells: A Principal Factor in the Early Stages of Aspirin-Induced Gastric Damage, Archiv. Toxicol.40, 143\u2013150 (1978).","journal-title":"Archiv. Toxicol."},{"key":"BF01998888_CR34","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1039\/jr9640006036","volume":"1964","author":"P.J. Wheatley","year":"1964","unstructured":"P.J. Wheatley,The Crystal and Molecular Structure of Aspirin, J. Chem. Soc.1964, 6036\u20136048 (1964).","journal-title":"J. Chem. Soc."},{"key":"BF01998888_CR35","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/jps.2600650549","volume":"65","author":"H. Bundgaard","year":"1976","unstructured":"H. Bundgaard andK. Larsen,Intramolecular and Intermolecular Transformations of Aspirin in Nonhydroxylic Solvents, J. Pharm. Sci.65, 776\u2013778 (1976).","journal-title":"J. Pharm. Sci."},{"key":"BF01998888_CR36","first-page":"1360","volume":"5","author":"A. Lespagnol","year":"1938","unstructured":"A. Lespagnol andM. Bar,Sur l'hydrolyse d'homologues superieurs de l'acide acetylsalicylique, Mem. Soc. Chim.5, 1360\u20131365 (1938).","journal-title":"Mem. Soc. Chim."},{"key":"BF01998888_CR37","unstructured":"T.Y. Shen,Anti-Inflammatory Agents, in:Topics in Medicinal Chemistry, vol. I (Eds. J.L. Rabinowitz and R.M. Myerson; Interscience, New York), pp. 29\u201378."},{"key":"BF01998888_CR38","first-page":"1","volume-title":"Clinoral in the Treatment of Rheumatic Disorders","author":"T.Y. Shen","year":"1976","unstructured":"T.Y. Shen,Discovery and Characterization of Sulindac and its Metabolites, in:Clinoral in the Treatment of Rheumatic Disorders (Eds. E.S. Huskisson and P. Franchimont; Raven Press, New York, 1976), pp. 1\u20138."}],"container-title":["Agents and Actions"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01998888.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF01998888\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF01998888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T21:14:24Z","timestamp":1586380464000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF01998888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,12]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,12]]}},"alternative-id":["BF01998888"],"URL":"https:\/\/doi.org\/10.1007\/bf01998888","relation":{},"ISSN":["0065-4299","1420-908X"],"issn-type":[{"value":"0065-4299","type":"print"},{"value":"1420-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,12]]}}}