{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:05:48Z","timestamp":1756994748416},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1983,4,1]],"date-time":"1983-04-01T00:00:00Z","timestamp":418003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. J, Clin. Microbiol."],"published-print":{"date-parts":[[1983,4]]},"DOI":"10.1007\/bf02001576","type":"journal-article","created":{"date-parts":[[2005,8,4]],"date-time":"2005-08-04T22:13:49Z","timestamp":1123193629000},"page":"116-121","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacokinetics of multiple doses of ceftizoxime and their influence on fecal flora"],"prefix":"10.1007","volume":"2","author":[{"given":"H.","family":"Lode","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Warns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kemmerich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Knothe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Koeppe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02001576_CR1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1128\/AAC.20.3.332","volume":"20","author":"A. Eley","year":"1981","unstructured":"Eley, A., Greenwood, D.: In vitro activity of ceftizoxime againstBacteroides fragilis: comparison with benzylpenicillin, cephalothin, and cefoxitin. Antimicrobial Agents and Chemotherapy 1981, 20: 332\u2013335.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"BF02001576_CR2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/AAC.17.4.583","volume":"17","author":"K. P. Fu","year":"1980","unstructured":"Fu, K. P., Neu, H. C.: Antibacterial activity of ceftizoxime, a \u03b2-lactamase stable cephalosporin. Antimicrobial Agents and Chemotherapy 1980, 17: 583\u2013590.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"BF02001576_CR3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1128\/AAC.19.3.393","volume":"19","author":"Y. Shigi","year":"1981","unstructured":"Shigi, Y., Kojo, H., Wakasuji, Nishida, M.: Differences between ceftizoxime and its stereoisomer in antibacterial activity and affinity for penicillinbinding proteins. Antimicrobial Agents and Chemotherapy 1981, 19: 393\u2013396.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"BF02001576_CR4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1128\/AAC.19.3.397","volume":"19","author":"N. Tahata","year":"1981","unstructured":"Tahata, N., Suginaka, H., Kotani, S., Ogawa, M., Kosaki, G.: \u03b2-lactam resistance inSerratia marcescens: comparison of action of benzylpenicillin, apalcillin, cefazolin, and ceftizoxime. Antimicrobial Agents and Chemotherapy 1981, 19: 397\u2013401.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"BF02001576_CR5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1128\/AAC.20.1.136","volume":"20","author":"E. Yabuuchi","year":"1981","unstructured":"Yabuuchi, E., Ito, T., Tanimura, E., Yamamoto, E., Okyama, A.: In vitro antimicrobial activity of ceftizoxime against glucose-non-fermentative gram-negative rods. Antimicrobial Agents and Chemotherapy 1981, 20: 136\u2013139.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"BF02001576_CR6","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1128\/AEM.14.2.170-177.1966","volume":"14","author":"J. V. Bennett","year":"1966","unstructured":"Bennett, J. V., Brodie, J. L., Brenner, E. J., Kirby, W. M. M.: Simplified accurate method for antibiotic assay of clinical specimens. Applied Microbiology 1966, 14: 170\u2013178.","journal-title":"Applied Microbiology"},{"key":"BF02001576_CR7","first-page":"21","volume-title":"Selected topics in clinical bacteriology","author":"D. S. Reeves","year":"1976","unstructured":"Reeves, D. S., Bywater, M. F.: Assay of antimicrobial agents. In: de Louovis, J. (ed.): Selected topics in clinical bacteriology. Bailli\u00e9re Tindall, London, 1976, p. 21\u201378."},{"key":"BF02001576_CR8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1128\/AAC.8.4.396","volume":"8","author":"H. Lode","year":"1975","unstructured":"Lode, H., Kemmerich, B., Koeppe, P.: Comparative clinical pharmacology of gentamicin, sisomicin, and tobramycin. Antimicrobial Agents and Chemotherapy 1975, 8: 396\u2013401.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"BF02001576_CR9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1128\/AAC.20.3.366","volume":"20","author":"M. C. Neu","year":"1981","unstructured":"Neu, M. C., Subramariam, S.: Pharmacology of ceftizoxime compared with that of cefamandole. Antimicrobial Agents and Chemotherapy 1981, 20: 366\u2013369.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"BF02001576_CR10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/j.1552-4604.1981.tb01738.x","volume":"21","author":"N. Nahashima","year":"1981","unstructured":"Nahashima, N., Suzuki, U., Hashimoto, H., Nishijima, K.: Phase I study of ceftizoxime, a new cephalosporin. Single-dose study. Journal of Clinical Pharmacology 1981, 21: 388\u2013395.","journal-title":"Journal of Clinical Pharmacology"},{"key":"BF02001576_CR11","first-page":"316","volume":"10","author":"S. M. Finegold","year":"1965","unstructured":"Finegold, S. M., Posnick, P. J., Miller, L. G., Hewitt, W. L.: The effect of various antibacterial compounds on the normal human fecal flora. Ern\u00e4hrungsforschung 1965, 10: 316\u2013341.","journal-title":"Ern\u00e4hrungsforschung"},{"key":"BF02001576_CR12","first-page":"158","volume-title":"Handbook of basic pharmacokinetics","author":"W. A. Ritschel","year":"1980","unstructured":"Ritschel, W. A.: Handbook of basic pharmacokinetics. Drug Intelligence Publications, Hamilton, 1980, pp. 158\u2013295."},{"key":"BF02001576_CR13","first-page":"237","volume-title":"Biopharmaceutics and relevant pharmacokinetics","author":"J. G. Wagner","year":"1971","unstructured":"Wagner, J. G.: Biopharmaceutics and relevant pharmacokinetics. Drug Intelligence Publications, Hamilton, 1971, pp. 237\u2013296."},{"key":"BF02001576_CR14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0010-468X(80)90058-6","volume":"12","author":"P. Koeppe","year":"1980","unstructured":"Koeppe, P., Hamann, C.: A program for nonlinear regression analysis to be used on desk-top computers. Computer Programs in Biomedicine 1980, 12: 121\u2013128.","journal-title":"Computer Programs in Biomedicine"},{"key":"BF02001576_CR15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/jps.2600590107","volume":"59","author":"J. C. K. Loo","year":"1970","unstructured":"Loo, J. C. K., Riegelmann, S.: Assessment of pharmacokinetic constants from post-infusion blood curves obtained after i.v. infusion. Journal of Pharmacological Science 1970, 59: 53\u201357.","journal-title":"Journal of Pharmacological Science"},{"key":"BF02001576_CR16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1056\/NEJM197510022931406","volume":"293","author":"D. F. Greenblatt","year":"1975","unstructured":"Greenblatt, D. F., Koch-Weser, J.: Clinical pharmacokinetics. New England Journal of Medicine 1975, 293: 702\u2013705.","journal-title":"New England Journal of Medicine"},{"key":"BF02001576_CR17","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1128\/AAC.20.5.567","volume":"20","author":"R. L\u00fcthy","year":"1981","unstructured":"L\u00fcthy, R., Blaser, J., Bonetti, A., Siegenthaler, W.: Comparative multiple dose pharmacokinetics of cefotaxime, moxalactam and ceftazidime. Antimicrobial Agents and Chemotherapy 1981, 20: 567\u2013572.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"BF02001576_CR18","first-page":"313","volume":"i","author":"N. Datta","year":"1971","unstructured":"Datta, N., Faiers, M. C., Reeves, D. C., Brumfitt, W., Orskov, F., Orskov, I.: R factors inEscherichia coli in faeces after oral chemotherapy in general practice. Lancet 1971, i: 313\u2013315.","journal-title":"Lancet"},{"key":"BF02001576_CR19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1099\/00222615-11-2-125","volume":"11","author":"C. L. Hartley","year":"1978","unstructured":"Hartley, C. L., Clements, H. M., Linton, H. B.: Effects of cephalothin, erythromycin and clindamycin on the aerobic gram-negative faecal flora in man. Journal of Medical Microbiology 1978, 11: 125\u2013135.","journal-title":"Journal of Medical Microbiology"},{"key":"BF02001576_CR20","first-page":"262","volume":"125","author":"H. Knothe","year":"1977","unstructured":"Knothe, H.: Eigenschaften der Chemotherapeutika und deren Einflu\u00df auf die k\u00f6rpereigene Flora. Wochenschrift der Kinderheilkunde 1977, 125: 262\u2013267.","journal-title":"Wochenschrift der Kinderheilkunde"},{"key":"BF02001576_CR21","first-page":"893","volume":"219","author":"G. Schroeter","year":"1970","unstructured":"Schroeter, G., Seeliger, H. P. R., Knothe, H.: Der Einflu\u00df der Antibiotika auf die Darmflora des Menschen. Zentralblatt f\u00fcr Bakteriologie, Parasitenkunde, Infektion und Hygiene 1970, 219: 893\u2013936.","journal-title":"Infektion und Hygiene"},{"key":"BF02001576_CR22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.7326\/0003-4819-77-5-707","volume":"77","author":"S. C. Schimpff","year":"1972","unstructured":"Schimpff, S. C., Young, V. M., Greene, W. H., Vermeulen, G. D., Moody, M. R., Wiesnik, M. D.: Origin of infection in acute nonlymphatic leukemia. Significance of hospital acquisition of potential pathogens. Annals of Internal Medicine 1972, 77: 707\u2013714.","journal-title":"Annals of Internal Medicine"},{"key":"BF02001576_CR23","first-page":"504","volume":"124","author":"C. M. Harno\u00df","year":"1982","unstructured":"Harno\u00df, C. M., Fangmann, B., Lode, H., Wagner, J.: Sepsis \u2014 Aktuelle Aspekte zur \u00c4tiologie, Klinik und Prognose bei 220 Patienten. M\u00fcnchner Medizinische Wochenschrift 1982, 124: 504\u2013506. 506.","journal-title":"M\u00fcnchner Medizinische Wochenschrift"},{"key":"BF02001576_CR24","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1056\/NEJM197402212900803","volume":"290","author":"W. E. Sanders","year":"1974","unstructured":"Sanders, W. E., Johnson, J. E., Taggart, J. G.: Adverse reactions to cephalothin and cephapirin. Uniform occurrence on prolonged intravenous administration of high doses. New England Journal of Medicine 1974, 290: 424\u2013427.","journal-title":"New England Journal of Medicine"}],"container-title":["European Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02001576.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02001576\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02001576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T17:58:01Z","timestamp":1586368681000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02001576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,4]]}},"alternative-id":["BF02001576"],"URL":"https:\/\/doi.org\/10.1007\/bf02001576","relation":{},"ISSN":["0722-2211","1435-4373"],"issn-type":[{"value":"0722-2211","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,4]]}}}