{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:51:23Z","timestamp":1785858683948,"version":"3.56.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,1]]},"DOI":"10.1007\/bf02047216","type":"journal-article","created":{"date-parts":[[2005,8,11]],"date-time":"2005-08-11T08:55:26Z","timestamp":1123750526000},"page":"58-62","source":"Crossref","is-referenced-by-count":53,"title":["Intermittent therapy with high-dose 5-aminosalicylic acid enemas maintains remission in ulcerative proctitis and proctosigmoiditis"],"prefix":"10.1097","volume":"37","author":[{"given":"Gerassimos J.","family":"Mantzaris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanassios","family":"Hatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalliopi","family":"Petraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charis","family":"Spiliadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Triantaphyllou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02047216_CR1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0016-5085(52)80128-3","volume":"21","author":"LM Morrison","year":"1952","unstructured":"Morrison LM. Results of treatment of ulcerative colitis with salicylazosulfapyridine. Gastroenterology 1952;21:133.","journal-title":"Gastroenterology"},{"key":"BF02047216_CR2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0016-5085(54)80065-5","volume":"26","author":"N Svartz","year":"1954","unstructured":"Svartz N. The treatment of ulcerative colitis. Gastroenterology 1954;26:26\u20138.","journal-title":"Gastroenterology"},{"key":"BF02047216_CR3","doi-asserted-by":"crossref","first-page":"879","DOI":"10.7326\/0003-4819-51-5-879","volume":"51","author":"OG Moertel","year":"1959","unstructured":"Moertel OG, Bargen JA. A critical analysis of the use of salicylazosulfapyridine in chronic ulcerative colitis. Ann Intern Med 1959;51:879\u201389.","journal-title":"Ann Intern Med"},{"key":"BF02047216_CR4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/gut.5.5.437","volume":"5","author":"JJ Misiewicz","year":"1964","unstructured":"Misiewicz JJ, Lennard-Jones JE, Connel AM. Controlled trial of sulphasalazine in maintenance therapy for ulcerative colitis. Gut 1964;5:437\u201342.","journal-title":"Gut"},{"key":"BF02047216_CR5","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1136\/gut.14.12.923","volume":"14","author":"AS Dissanayake","year":"1973","unstructured":"Dissanayake AS, Truelove SC. A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphasalazine (Salazopyrin). Gut 1973;14:923\u20136.","journal-title":"Gut"},{"key":"BF02047216_CR6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/gut.21.3.232","volume":"21","author":"AK Azad-Khan","year":"1980","unstructured":"Azad-Khan AK, Howes DT, Piris J, Truelove SC. Optimum dose of sulphasalazine for maintenance treatment of ulcerative colitis. Gut 1980;21:232\u201340.","journal-title":"Gut"},{"key":"BF02047216_CR7","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0140-6736(77)90831-5","volume":"2","author":"AK Azad Khan","year":"1977","unstructured":"Azad Khan AK, Piris J, Truelove SC. An experiment to determine the active therapeutic moiety of sulphasalazine. Lancet 1977;2:892\u20135.","journal-title":"Lancet"},{"key":"BF02047216_CR8","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","volume":"317","author":"KW Schroeder","year":"1987","unstructured":"Schroeder KW, Tremaine WJ, Ilstrup DM. Coated 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. N Engl J Med 1987;317:1625\u20139.","journal-title":"N Engl J Med"},{"key":"BF02047216_CR9","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/bmj.291.6506.1373","volume":"291","author":"WS Selby","year":"1985","unstructured":"Selby WS, Barr GD, Ireland A, Mason CH, Jewell DP. Olsalazine in active ulcerative colitis. BMJ 1985;291:1373\u20135.","journal-title":"BMJ"},{"key":"BF02047216_CR10","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/0016-5085(88)90677-4","volume":"94","author":"SA Riley","year":"1988","unstructured":"Riley SA, Mani V, Goodman MJ, Herd ME, Dutt S, Turnberg LA. Comparison of delayed-release 5-aminosalicylic acid (mesalazine) and sulfasalazine as maintenance treatment for patients with ulcerative colitis. Gastroenterology 1988;94:1383\u20139.","journal-title":"Gastroenterology"},{"key":"BF02047216_CR11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2036.1989.tb00204.x","volume":"3","author":"P Rutgesrts","year":"1989","unstructured":"Rutgesrts P. Comparative efficacy of coated oral 5-aminosalicylic acid (Claversal) and sulphasalazine for maintaining remission of ulcerative colitis. Aliment Pharmacol Ther 1989;3:183\u201391.","journal-title":"Aliment Pharmacol Ther"},{"key":"BF02047216_CR12","first-page":"271","volume":"2","author":"M Campieri","year":"1981","unstructured":"Campieri M, Lanfranchi GA, Bazzocchi G. Treatment of ulcerative colitis with a high-dose 5-aminosalicylic acid enemas. Lancet 1981;2:271\u20132.","journal-title":"Lancet"},{"key":"BF02047216_CR13","first-page":"910","volume":"42","author":"G Basilisco","year":"1987","unstructured":"Basilisco G, Ranzi T, Campanini M, Piodi L, Velio P, Bianchi PA. 5-Aminosalicylic acid or sulphasalazine retention enemas in distal ulcerative colitis. Curr Ther Res 1987;42:910\u20135.","journal-title":"Curr Ther Res"},{"key":"BF02047216_CR14","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/0016-5085(87)90621-4","volume":"92","author":"LR Sutherland","year":"1987","unstructured":"Sutherland LR, Martin F, Greer S,et al. 5-Aminosalicylic acid enemas in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology 1987;92:1894\u20138.","journal-title":"Gastroenterology"},{"key":"BF02047216_CR15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/gut.29.5.669","volume":"29","author":"SA Riley","year":"1983","unstructured":"Riley SA, Mani V, Goodman MJ, Herd ME, Dutt S, Turnberg LA. Comparison of delayed-release 5-aminosalicylic acid (mesalazine) and sulfasalazine in treatment of mild to moderate ulcerative colitis relapse. Gut 1983;29:669\u201374.","journal-title":"Gut"},{"key":"BF02047216_CR16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1155\/1987\/846392","volume":"1","author":"LR Sutherland","year":"1987","unstructured":"Sutherland LR, Martin F. 5-Aminosalicylic acid enemas in the maintenance of remission in distal ulcerative colitis and proctitis. Can J Gastroenterol 1987;1:3\u20136.","journal-title":"Can J Gastroenterol"},{"key":"BF02047216_CR17","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0016-5085(88)90569-0","volume":"94","author":"WI Biddle","year":"1988","unstructured":"Biddle WI, Greenberger NJ, Swan JT, MvPhee MS, Miner PB. 5-Aminosalicylic acid enemas: effective agent in maintaining remission in left-sided ulcerative colitis. Gastroenterology 1988;94:1075\u20139.","journal-title":"Gastroenterology"},{"key":"BF02047216_CR18","first-page":"1079","volume":"85","author":"A d'Arienzo","year":"1990","unstructured":"d'Arienzo A, Panarese A, D'Armiento FP,et al. 5-Aminosalicylic acid suppositories in the maintenance of remission in idiopathic proctitis or proctosigmoiditis: a double-blind placebo-controlled clinical trial. Am J Gastroenterol 1990;85:1079\u201382.","journal-title":"Am J Gastroenterol"},{"key":"BF02047216_CR19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/BF02156265","volume":"33","author":"G d'Albasio","year":"1990","unstructured":"d'Albasio G, Trallori G, Ghetti A,et al. Intermittent therapy with high-dose 5-aminosalicylic acid enemas for maintaining remission in ulcerative proctosigmoiditis. Dis Colon Rectum 1990;33:394\u20137.","journal-title":"Dis Colon Rectum"},{"key":"BF02047216_CR20","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1136\/bmj.2.4947.1041","volume":"2","author":"SC Truelove","year":"1955","unstructured":"Truelove SC, Witts IJ. Cortisone in ulcerative colitis: final report on therapeutic trial. BMJ 1955;2:1041\u20138.","journal-title":"BMJ"},{"key":"BF02047216_CR21","first-page":"412","volume":"6","author":"LS Friedman","year":"1986","unstructured":"Friedman LS, Richter JM, Sara EK,et al. 5-Aminosalicylic acid enemas in refractory distal ulcerative colitis: a randomized controlled trial. Am J Gastroenterol 1986;6:412\u20139.","journal-title":"Am J Gastroenterol"},{"key":"BF02047216_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","volume":"35","author":"P Peto","year":"1977","unstructured":"Peto P, Pike MC, Armitage P. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 1977;35:1\u201339.","journal-title":"Br J Cancer"},{"key":"BF02047216_CR23","first-page":"43","volume":"1","author":"A Ireland","year":"1989","unstructured":"Ireland A, Jewell DP. Sulphasalazine and the new salicylates. Eur J Gastroenterol Hepatol 1989;1:43\u201350.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"BF02047216_CR24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-94-009-2488-8_2","volume-title":"Clinical research in gastroenterology. Vol 2","author":"U Klotz","year":"1989","unstructured":"Klotz U. Clinical pharmacology of mesalazine (5-aminosalicylic acid) in chronic inflammatory bowel disease. In: Matern S, ed. Clinical research in gastroenterology. Vol 2. Boston: Kluwer Academic Publishers, 1989:17\u201330."},{"key":"BF02047216_CR25","first-page":"12","volume":"23","author":"G d'Albasio","year":"1991","unstructured":"d'Albasio G, Trallori G, Gavazzi O,et al. Combined therapy with 5-aminosalicylic tablets and enemas for maintaining remission in ulcerative colitis. Ital J Gastroenterol 1991;23:12\u20134.","journal-title":"Ital J Gastroenterol"}],"container-title":["Diseases of the Colon &amp; Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00003453-199437010-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:56:11Z","timestamp":1785855371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-199437010-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02047216","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}