{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:46:45Z","timestamp":1785858405057,"version":"3.56.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,9]]},"DOI":"10.1007\/bf02051076","type":"journal-article","created":{"date-parts":[[2005,8,11]],"date-time":"2005-08-11T14:25:10Z","timestamp":1123770310000},"page":"810-815","source":"Crossref","is-referenced-by-count":1,"title":["Multiple primary colorectal adenocarcinomas"],"prefix":"10.1097","volume":"34","author":[{"given":"Inger","family":"Magnusson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula G.","family":"Falkmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02051076_CR1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF02587230","volume":"18","author":"RJ Heald","year":"1975","unstructured":"Heald RJ, Bussey HJ. Clinical experiences at St. Mark's hospital with multiple synchronous cancers of the colon and rectum. Dis Colon Rectum 1975;18:6\u201310.","journal-title":"Dis Colon Rectum"},{"key":"BF02051076_CR2","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/bjs.1800711210","volume":"71","author":"WJ Cunliffe","year":"1984","unstructured":"Cunliffe WJ, Hasleton PS, Tweedle DE, Schofield PF. Incidence of synchronous and metachronous colorectal carcinoma. Br J Surg 1984;71:941\u20133.","journal-title":"Br J Surg"},{"key":"BF02051076_CR3","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF02555051","volume":"29","author":"PJ Kiefer","year":"1986","unstructured":"Kiefer PJ, Thorson AG, Christensen MA. Metachronous colorectal cancer: time interval to presentation of a metachronous cancer. Dis Colon Rectum 1986;29:378\u201382.","journal-title":"Dis Colon Rectum"},{"key":"BF02051076_CR4","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/bjs.1800741021","volume":"74","author":"PJ Finan","year":"1987","unstructured":"Finan PJ, Ritchie JK, Hawley PR. Synchronous and \u2018early\u2019 metachronous carcinomas of the colon and rectum. Br J Surg 1987;74:945\u20137.","journal-title":"Br J Surg"},{"key":"BF02051076_CR5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0002-9610(84)90161-2","volume":"147","author":"JM Langevin","year":"1984","unstructured":"Langevin JM, Nivatvongs S. The true incidence of synchronous cancer of the large bowel: a prospective study. Am J Surg 1984;147:330\u20133.","journal-title":"Am J Surg"},{"key":"BF02051076_CR6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/bjc.1958.37","volume":"12","author":"CE Dukes","year":"1958","unstructured":"Dukes CE, Bussey HJ. The spread of rectal cancer and its effect on prognosis. Br J Cancer 1958;12:309\u201320.","journal-title":"Br J Cancer"},{"key":"BF02051076_CR7","first-page":"675","volume":"151","author":"U \u00d6hman","year":"1985","unstructured":"\u00d6hman U. Colorectal carcinoma: a survey of 1345 cases 1950\u20131984. Acta Chir Scand 1985;151:675\u20139.","journal-title":"Acta Chir Scand"},{"key":"BF02051076_CR8","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/archsurg.1987.01400240021002","volume":"122","author":"NA Scott","year":"1987","unstructured":"Scott NA, Wieand HS, Moertel CG, Cha SS, Beart RW, Lieber MM. Colorectal cancer: Dukes' stage, tumor site, preoperative plasma CEA level, and patient prognosis related to tumor DNA ploidy pattern. Arch Surg 1987;122:1375\u20139.","journal-title":"Arch Surg"},{"key":"BF02051076_CR9","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/00000658-198902000-00009","volume":"209","author":"WA Kokal","year":"1989","unstructured":"Kokal WA, Gardine RL, Sheibani K,et al. Tumor DNA content in resectable, primary colorectal carcinoma. Ann Surg 1989;209:188\u201393.","journal-title":"Ann Surg"},{"key":"BF02051076_CR10","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/bjs.1800721018","volume":"72","author":"NC Armitage","year":"1985","unstructured":"Armitage NC, Robins RA, Evans DF, Turner DR, Baldwin RW, Hardcastle JD. The influence of tumor cell DNA abnormalities on survival in colorectal cancer. Br J Surg 1985;72:828\u201330.","journal-title":"Br J Surg"},{"key":"BF02051076_CR11","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0344-0338(89)80232-8","volume":"185","author":"A-R Weger","year":"1989","unstructured":"Weger A-R, Mikuz G, Askensten U, Auer GU, Schwab G, Glaser KS. Methodological aspects of DNA image cytometry in formalin-fixed paraffin-embedded material from pancreatic adenocarcinoma. Pathol Res Pract 1989;185:752\u20134.","journal-title":"Pathol Res Pract"},{"key":"BF02051076_CR12","first-page":"168","volume":"13","author":"H Ull\u00e9n","year":"1991","unstructured":"Ull\u00e9n H, Falkmer UG, Collins VP, Auer GU. Methodologic aspects of nuclear DNA assessment of gliomas with astrocytic and\/or oligodendrocytic differentiation. Correlation of image and flow cytometric studies on paraffin-embedded specimens. Anal Quant Cytol Histol 1991;13:168\u201376.","journal-title":"Anal Quant Cytol Histol"},{"key":"BF02051076_CR13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/cyto.990060314","volume":"6","author":"AM Driel-Kulker van","year":"1985","unstructured":"van Driel-Kulker AM, Mesker WE, van Velzen I, Tanke HJ, Feichtinger J, Ploem JS. Preparation of monolayer smears from paraffin-embedded tissue for image cytometry. Cytometry 1985;6:268\u201372.","journal-title":"Cytometry"},{"key":"BF02051076_CR14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0014-4827(75)90386-9","volume":"92","author":"J Gaub","year":"1975","unstructured":"Gaub J, Auer G, Zetterberg A. Quantitative cytochemical aspects of a combined Feulgen-Naphthol Yellow S Staining procedure for the simultaneous determination of nuclear and cytoplasmic proteins and DNA in mammalian cells. Exp Cell Res 1975;92:323\u201332.","journal-title":"Exp Cell Res"},{"key":"BF02051076_CR15","first-page":"161","volume":"2","author":"GU Auer","year":"1980","unstructured":"Auer GU, Caspersson TO, Wallgren AS. DNA content and survival in mammary carcinoma. Anal Quant Cytol 1980;2:161\u20135.","journal-title":"Anal Quant Cytol"},{"key":"BF02051076_CR16","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1002\/1097-0142(19841101)54:9<1870::AID-CNCR2820540917>3.0.CO;2-5","volume":"54","author":"N Kaibara","year":"1984","unstructured":"Kaibara N, Koga S, Jinnai D. Synchronous and metachronous malignancies of the colon and rectum in Japan with special reference to a coexisting early cancer. Cancer 1984;54:1870\u20134.","journal-title":"Cancer"},{"key":"BF02051076_CR17","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/1097-0142(19861101)58:9<2082::AID-CNCR2820580920>3.0.CO;2-J","volume":"58","author":"D Schwartz","year":"1986","unstructured":"Schwartz D, Banner BF, Roseman DL, Coon JS. Origin of multiple \u201cprimary\u201d colon carcinomas: a retrospective flow cytometric study. Cancer 1986;58:2082\u20138.","journal-title":"Cancer"},{"key":"BF02051076_CR18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/bjc.1987.257","volume":"56","author":"TO Rognum","year":"1987","unstructured":"Rognum TO, Thorud E, Lund E. Survival of large bowel carcinoma patients with different DNA ploidy. Br J Cancer 1987;56:633\u20136.","journal-title":"Br J Cancer"},{"key":"BF02051076_CR19","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/00000658-198512000-00014","volume":"202","author":"BF Banner","year":"1985","unstructured":"Banner BF, Tomas-de la Vega JE, Roseman DL, Coon JS. Should flow cytometric DNA analysis precede definitive surgery for colon carcinoma? Ann Surg 1985;202:740\u20134.","journal-title":"Ann Surg"},{"key":"BF02051076_CR20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0002-9610(05)80259-4","volume":"159","author":"TM Heimann","year":"1990","unstructured":"Heimann TM, Miller F, Martinelli G,et al. Significance of DNA content abnormalities in small rectal cancers. Am J Surg 1990;159:199\u2013203.","journal-title":"Am J Surg"},{"key":"BF02051076_CR21","unstructured":"Falkmer UG. Methodological aspects on DNA cytometry. Image and flow cytometry on malignant tumors of the breast, the endometrium, the brain and the salivary glands. Thesis. Karolinska Institute. 1989."}],"container-title":["Diseases of the Colon &amp; Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00003453-199134090-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:52:46Z","timestamp":1785855166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-199134090-00016"}},"subtitle":["Cytometric DNA ploidy patterns and histopathologic features"],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1991]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02051076","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}