{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:59:12Z","timestamp":1759481952387},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A randomized open trial was undertaken to compare the antithrombotic efficacy of a low molecular weight heparin (LMWH; Sandoparin\u00ae) with that of dextran 70\u00a0in patients undergoing surgery for hip fracture. One hundred thirteen patients received LMWH once daily subcutaneously at a fixed dosage while 103 patients received intravenous dextran 70. Postoperative deep vein thrombosis (DVT) was assessed by a diagnostic algorithm using the<jats:sup>125<\/jats:sup>Iodine fibrinogen uptake test as screening and Duplex ultrasonography and\/or ascending venography as confirming techniques for suspected DVT. The frequency of DVT was significantly lower in the LMWH group than in the dextran group (15.5 versus 32.6%,<jats:italic>p<\/jats:italic>&lt;0.005). Proximal DVT was rare in both groups (LMWH: 2%, Dextran: 1%). Only one case of fatal fat pulmonary embolism was observed during the 10\u00a0day prophylaxis period in a patient receiving Dextran. Three cases of pulmonary embolism occurred later; one fatal event in the dextran group on day 14, and two cases in the LMWH group (one fatal and one non\u2010fatal event) on day 14 and 17, respectively. There was no major bleeding complication in either group. We conclude that the LMWH we used is safe, was well tolerated, and has a significantly better thromboprophylactic effect than dextran 70.<\/jats:p>","DOI":"10.1007\/bf02067011","type":"journal-article","created":{"date-parts":[[2005,8,12]],"date-time":"2005-08-12T14:40:31Z","timestamp":1123857631000},"page":"980-984","source":"Crossref","is-referenced-by-count":16,"title":["Prevention of deep vein thrombosis in patients with hip fractures: Low molecular weight heparin versus dextran"],"prefix":"10.1002","volume":"16","author":[{"given":"D.","family":"Oertli","sequence":"first","affiliation":[{"name":"Departments of Surgery, Nuclear Medicine, and Angiology University Hospital Basel Switzerland"},{"name":"Department Chirurgie Kantonsspital Basel Spitalstrasse 21 CH\u201004031 Basel Switzerland"},{"name":"CONSULT AG Statistical Consulting Company Berne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hess","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Nuclear Medicine, and Angiology University Hospital Basel Switzerland"},{"name":"CONSULT AG Statistical Consulting Company Berne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"D\u016brig","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Nuclear Medicine, and Angiology University Hospital Basel Switzerland"},{"name":"CONSULT AG Statistical Consulting Company Berne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Laffer","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Nuclear Medicine, and Angiology University Hospital Basel Switzerland"},{"name":"CONSULT AG Statistical Consulting Company Berne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fridrich","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Nuclear Medicine, and Angiology University Hospital Basel Switzerland"},{"name":"CONSULT AG Statistical Consulting Company Berne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Jaeger","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Nuclear Medicine, and Angiology University Hospital Basel Switzerland"},{"name":"CONSULT AG Statistical Consulting Company Berne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Nuclear Medicine, and Angiology University Hospital Basel Switzerland"},{"name":"CONSULT AG Statistical Consulting Company Berne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Harder","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Nuclear Medicine, and Angiology University Hospital Basel Switzerland"},{"name":"CONSULT AG Statistical Consulting Company Berne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,9]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"31","article-title":"Prophylaxis of postoperative thromboembolism with low dose heparin alone or in combination with dihydroergotamine: A review","volume":"543","author":"Lindblad B.","year":"1988","journal-title":"Acta Chir. 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