{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:23:03Z","timestamp":1770823383347,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Because 80% of patients with primary hyperparathyroidism have a single adenoma and because most adenomas are now visualized by ultrasonography, we have attempted to remove these suspected single adenomas under local anesthesia with intra\u2010operative monitoring of urinary cAMP (UcAMP) and 1\u201084 parathyroid hormone (PTH) serum levels. In the last 2 years, 45 patients (mean age 65 years) with primary hyperparathyroidism underwent surgery with local anesthesia when a single adenoma was strongly suspected by ultrasonography. Patients with equivocal or misleading ultrasonography, e.g., those with associated thyroid or multiglandular pathology and those who were non\u2010cooperative, were excluded from this procedure. UcAMP and 1\u201084\u00a0PTH were determined prior to the incision, at the time of removal of the adenoma, and at regular intervals until 120\u00a0minutes after the operation. Results were available 45\u00a0min to 60\u00a0min after sampling for PTH and 60\u00a0min to 80\u00a0min for UcAMP. Forty\u2010two adenomas were removed through a 2\u00a0cm to 3\u00a0cm skin incision in a mean time of 25\u00a0minutes, with no adverse effect, no morbidity, and minimal discomfort. The 42 patients were normocalcaemic on follow\u2010up. The monitorings always predicted the success of the operation. In the 3\u00a0remaining patients, because the monitorings remained elevated at the end of the procedure, the patients underwent classical bilateral neck dissection under general anesthesia. This new approach can be safely accomplished with short operative time and hospital stay. The absence of general anesthesia is reassuring for the patients who are reluctant to undergo general anesthesia. The intra\u2010operative monitoring which predicts the cure of primary hyperparathyroidism with high accuracy allows the surgeon to conclude the operation with confidence.<\/jats:p>","DOI":"10.1007\/bf02067323","type":"journal-article","created":{"date-parts":[[2005,8,13]],"date-time":"2005-08-13T21:45:46Z","timestamp":1123969546000},"page":"570-575","source":"Crossref","is-referenced-by-count":46,"title":["Parathyroid adenomectomy under local anesthesia with intra\u2010operative monitoring of UcAMP and\/or 1\u201084\u00a0PTH"],"prefix":"10.1002","volume":"16","author":[{"given":"Y.","family":"Chapuis","sequence":"first","affiliation":[{"name":"Department of Surgery, Nuclear Medicine, and Anatomopathology Hospital Cochin Paris France"},{"name":"Clinique Chirurgicale H\u00f4pital Cochin\u201027 rue du Faubourg Saint Jacques 75674 Paris Cedex 14 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ph.","family":"Icard","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nuclear Medicine, and Anatomopathology Hospital Cochin Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Fulla","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nuclear Medicine, and Anatomopathology Hospital Cochin Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Nonnenmacher","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nuclear Medicine, and Anatomopathology Hospital Cochin Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ph.","family":"Bonnichon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nuclear Medicine, and Anatomopathology Hospital Cochin Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Louvel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nuclear Medicine, and Anatomopathology Hospital Cochin Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nuclear Medicine, and Anatomopathology Hospital Cochin Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-2-198"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606053142304"},{"key":"e_1_2_1_4_1","first-page":"365","volume-title":"Endocrine Surgery Update","author":"Thompson N.W.","year":"1983"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30360-8"},{"key":"e_1_2_1_6_1","first-page":"1013","volume-title":"Endocrinology","author":"Norton J.A.","year":"1989"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(75)80073-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198203000-00001"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658540"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1988.01400290100017"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197603000-00010"},{"key":"e_1_2_1_12_1","first-page":"1923","article-title":"D\u00e9pistage ultrasonographique pr\u00e9\u2010op\u00e9ratoire des ad\u00e9nomes parathyro\u00efdiens","volume":"10","author":"Moreau J.F.","year":"1981","journal-title":"Nouv. 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