{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:10:36Z","timestamp":1791353436420,"version":"4.3.1"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined corneal nerves of 22 patients from 10 families with multiple endocrine neoplasia type 2A (MEN\u20102A). According to the findings in slit\u2010lamp biomicroscopic examination and photographic documentation, the increased visibility of corneal nerves were classified into 5\u00a0grades (Grade 0=invisible to Grade 4=as thick as in MEN\u20102B). All eyes of normal subjects, 19 of 20 eyes of patients with anterior keratoconus, and 11 of 12 eyes of patients with non\u2010hereditary medullary thyroid carcinoma (MTC) were either grade 0 or 1, and the remaining 2 eyes were evaluated as grade 2. Of the 44 eyes of MEN\u20102A patients, 5 (11.4%) eyes were grade 0, 11 (25%) eyes were grade 1, 19 (43.2%) eyes were grade 2, 8 (18.2%) eyes were grade 3, and 1 (2.3%) eye was grade 4. Thus, more than 60% of eyes of MEN\u20102A patients showed pathologically thickened corneal nerves of varying degree (grade 2 or higher). There was no definite relationship between the grade of corneal nerve thickening and the patient's age or presence of pheochromocytoma. Differences in the grade of corneal nerve thickening were observed among affected members belonging to the same MEN\u20102A family, but unaffected members of the family never showed prominent corneal nerves of grade 2 or higher. Our findings suggest that MTC patients with thickened corneal nerves might actually be MEN\u20102A patients and should be carefully followed for other components of this syndrome.<\/jats:p>","DOI":"10.1007\/bf02067337","type":"journal-article","created":{"date-parts":[[2005,8,13]],"date-time":"2005-08-13T21:45:46Z","timestamp":1123969546000},"page":"620-623","source":"Crossref","is-referenced-by-count":17,"title":["Prominent corneal nerves in patients with multiple endocrine neoplasia type 2A: Diagnostic implications"],"prefix":"10.1002","volume":"16","author":[{"given":"Shin\u2010Ichiro","family":"Takai","sequence":"first","affiliation":[{"name":"Department of Surgery II and Department of Ophthalmology Osaka University Medical School Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Surgery II and Department of Ophthalmology Osaka University Medical School Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Surgery II and Department of Ophthalmology Osaka University Medical School Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Surgery II and Department of Ophthalmology Osaka University Medical School Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Surgery II and Department of Ophthalmology Osaka University Medical School Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery II and Department of Ophthalmology Osaka University Medical School Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1992,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"359","volume-title":"Surgical Endocrinology","author":"Norton J.A.","year":"1990"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)72314-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(81)90175-6"},{"key":"e_1_2_1_5_1","first-page":"772","article-title":"Thickened corneal nerves as a manifestation of multiple endocrine neoplasia","volume":"79","author":"Robertson D.M.","year":"1975","journal-title":"Trans. Am. Acad. Ophthalmol. Otolaryngol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/328527a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/328528a0"},{"issue":"10","key":"e_1_2_1_8_1","article-title":"Update on linkage on the multiple endocrine neoplasia type 2B gene (MEN 2B) to chromosome 10 markers linked to MEN 2A","volume":"47","author":"Jackson C.E.","year":"1990","journal-title":"Am. J. Hum. Genet."}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02067337.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02067337\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02067337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T18:19:43Z","timestamp":1703701183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF02067337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1007\/BF02067337"],"URL":"https:\/\/doi.org\/10.1007\/bf02067337","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}