{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:23:28Z","timestamp":1759335808137},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[1994,12,1]],"date-time":"1994-12-01T00:00:00Z","timestamp":786240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1994,12]]},"DOI":"10.1007\/bf02087706","type":"journal-article","created":{"date-parts":[[2005,8,14]],"date-time":"2005-08-14T23:52:21Z","timestamp":1124063541000},"page":"2660-2664","source":"Crossref","is-referenced-by-count":26,"title":["Clinical and histologic predictors of response to interferon-\u03b1 in patients with chronic hepatitis C viral infection"],"prefix":"10.1007","volume":"39","author":[{"given":"Nancy P.","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lino J.","family":"DeGuzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pitrak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Layden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02087706_CR1","volume-title":"Intron A package insert","author":"Schering Corporation","year":"1992","unstructured":"Schering Corporation: Intron A package insert. Kenilworth, New Jersey, 1992 May"},{"key":"BF02087706_CR2","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1056\/NEJM198911303212203","volume":"321","author":"GL Davis","year":"1989","unstructured":"Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer Jr HC, Perrillo RP, Carey W, Jacobson IM, Payne J, Dienstag JL, Van Thiel DH, Tamburro CF, Lefkowitch J, Albrecht J, Meschievitz C, Ortego TJ, Gibas A, the Hepatitis Interventional Therapy Group: Treatment of chronic hepatitis C with recombinant interferon alfa: A multicenter, randomized, controlled study. N Engl J Med 321:1501\u20131506, 1989","journal-title":"N Engl J Med"},{"key":"BF02087706_CR3","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1056\/NEJM198911303212204","volume":"321","author":"AM Bisceglie Di","year":"1989","unstructured":"Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, Goodman Z, Banks SM, Hoofnagle JH: Recombinant interferon alfa therapy for chronic hepatitis C; a randomized double-blind placebo-controlled trial. N Engl J Med 321:1506\u20131510, 1989","journal-title":"N Engl J Med"},{"key":"BF02087706_CR4","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1016\/0168-8278(90)90165-N","volume":"11","author":"O Weiland","year":"1990","unstructured":"Weiland O, Schvarcz R, Wejstal R, Norkrans G, Fryden A: Therapy of chronic post-transfusion non-A, non-B hepatitis with interferon alfa-2b: Swedish experience. J Hepatol 11:S57-S62, 1990","journal-title":"J Hepatol"},{"key":"BF02087706_CR5","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/0168-8278(90)90163-L","volume":"11","author":"P Ferenci","year":"1990","unstructured":"Ferenci P, Vogel W, Pristautz H, Deimer J, Denk H, Judmaier G, Maier KP, Krejs GJ, Gangl A: One-year treatment of chronic non-A, non-B hepatitis with interferon alfa-2b. J Hepatol 11:S50-S53, 1990","journal-title":"J Hepatol"},{"key":"BF02087706_CR6","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/0168-8278(90)90166-O","volume":"11","author":"M Gomez-Rubio","year":"1990","unstructured":"Gomez-Rubio M, Porres JC, Castillo I, Quiroga JA, Moreno A, Carreno V: Prolonged treatment (18 months) of chronic hepatitis C with recombinant alpha-interferon in comparison with a control group. J Hepatol 11:S63-S67, 1990","journal-title":"J Hepatol"},{"issue":"4","key":"BF02087706_CR7","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/BF01316789","volume":"38","author":"S Iino","year":"1993","unstructured":"Iino S, Hino K, Kuroki T, Suzuki H, Yamamoto S: Treatment of chronic hepatitis C with high-dose interferon alpha-2b. A multicenter study. Dig Dis Sci 38(4):612\u2013618, 1993","journal-title":"Dig Dis Sci"},{"key":"BF02087706_CR8","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/106002807400801104","volume":"8","author":"BJ Devine","year":"1974","unstructured":"Devine BJ: Clinical pharmacy case studies\u2014gentamicin therapy. Drug Intell Clin Pharm 8:650\u2013655, 1974","journal-title":"Drug Intell Clin Pharm"},{"key":"BF02087706_CR9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","volume":"1","author":"RG Knodell","year":"1981","unstructured":"Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1:431\u2013435, 1981","journal-title":"Hepatology"},{"key":"BF02087706_CR10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2165\/00003088-198611030-00002","volume":"11","author":"DR Abernethy","year":"1986","unstructured":"Abernethy DR, Greenblatt DJ: Drug disposition in obese humans: An update. Clin Pharmacokinet 11:199\u2013231, 1986","journal-title":"Clin Pharmacokinet"},{"key":"BF02087706_CR11","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/BF00542215","volume":"24","author":"LA Bauer","year":"1983","unstructured":"Bauer LA, Drew Edwards WA, Patchen Dellinger E, Simmonowitz DA: Influence of weight on aminoglycosides pharmacokinetics in normal weight and morbidly obese patients. Eur J Clin Pharmacol 24:643\u2013647, 1983","journal-title":"Eur J Clin Pharmacol"},{"key":"BF02087706_CR12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/clpt.1985.66","volume":"37","author":"LA Bauer","year":"1985","unstructured":"Bauer LA, Wareing-Tran C, Drew Edwards WA, Raisys V, Ferreri L, Jack R, Dellinger EP, Simonowitz D: Cimetidine clearance in the obese. Clin Pharmacol Ther 37:425\u2013430, 1985","journal-title":"Clin Pharmacol Ther"},{"key":"BF02087706_CR13","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/j.1552-4604.1987.tb05582.x","volume":"27","author":"G Cheymol","year":"1987","unstructured":"Cheymol G, Poirier JM, Barre J, Pradalier A, Dry J: Comparative pharmacokinetics of intravenous propranolol in obese and normal volunteers. J Clin Pharmacol 27:874\u2013879, 1987","journal-title":"J Clin Pharmacol"},{"key":"BF02087706_CR14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00692355","volume":"25","author":"MJ Lind","year":"1989","unstructured":"Lind MJ, Margison JM, Cerny T, Thatcher N, Wilkinson PM: Prolongation of ifosfamide elimination half-life in obese patients due to altered drug distribution. Cancer Chemother Pharmacol 25:139\u2013142, 1989","journal-title":"Cancer Chemother Pharmacol"},{"key":"BF02087706_CR15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2165\/00003088-199222060-00006","volume":"22","author":"L Wilkes","year":"1992","unstructured":"Wilkes L, Danziger LH, Rodvold KA: Phenobarbital pharmacokinetics in obesity: A case report. Clin Pharmacokinet 22:481\u2013484, 1992","journal-title":"Clin Pharmacokinet"},{"key":"BF02087706_CR16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00007691-199101000-00004","volume":"13","author":"P Zuccaro","year":"1991","unstructured":"Zuccaro P, Guandalini S, Pacifici R, Pichini S, Di Martino L, Guiducci M, Giuliano M, Di Tullio MT, Pettoello-Mantovani M: Fat body mass and pharmacokinetics of 6-mercaptopurine in children with acute lymphoblastic leukemia. Ther Drug Monit 13:37\u201341, 1991","journal-title":"Ther Drug Monit"},{"key":"BF02087706_CR17","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1172\/JCI108599","volume":"58","author":"LC Harrison","year":"1976","unstructured":"Harrison LC, Martin FIR, Melick RA: Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects. J Clin Invest 58:1435\u20131441, 1976","journal-title":"J Clin Invest"},{"key":"BF02087706_CR18","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/0026-0495(84)90221-X","volume":"33","author":"AC Kashiwagi","year":"1984","unstructured":"Kashiwagi AC, Bogardus C, Lillioja S, Huecksteadt TP, Brady D, Verso MA, Foley JE:In vitro insensitivity of glucose transport and antilipolysis to insulin due to receptor and postreceptor abnormalities in obese Pima Indians with normal glucose tolerance. Metabolism 33:772\u2013777, 1984","journal-title":"Metabolism"},{"key":"BF02087706_CR19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/jcem-48-3-487","volume":"48","author":"OG Kolterman","year":"1979","unstructured":"Kolterman OG, Reaven GM, Olefsky JM: Relationship between in vivo insulin resistance and decreased insulin receptors in obese man. J Clin Endocrinol Metab 48:487\u2013494, 1979","journal-title":"J Clin Endocrinol Metab"},{"key":"BF02087706_CR20","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1172\/JCI109790","volume":"65","author":"OG Kolterman","year":"1980","unstructured":"Kolterman OG, Insel J, Saekow M, Olefsky JM: Mechanisms of insulin resistance in human obesity. Evidence for receptor and postreceptor defects. J Clin Invest 65:1272\u20131284, 1980","journal-title":"J Clin Invest"},{"key":"BF02087706_CR21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1365-2362.1971.tb00559.x","volume":"1","author":"P Bjorntorp","year":"1971","unstructured":"Bjorntorp P, Berchtold P, Holm J: The glucose uptake of human adipose tissue in obesity. Eur J Clin Invest 1:480\u2013488, 1971","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"BF02087706_CR22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/clpt.1990.112","volume":"48","author":"F Varin","year":"1990","unstructured":"Varin F, Ducharme J, Theoret Y, Besner JG, BeVan DR, Donati F: Influence of extreme obesity on the body disposition and neuromuscular blocking effect of atracurium. Clin Pharmacol Ther 48(1):18\u201325, 1990","journal-title":"Clin Pharmacol Ther"},{"key":"BF02087706_CR23","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/0168-8278(90)90162-K","volume":"11","author":"G Saracco","year":"1990","unstructured":"Saracco G, Rosina F, Torrani Cerenzia MR, Lattore V, Chiandussi L, Gallo V, Petrino R, DeMicheli AG, Donegani E, Solinas A, Deplano A, Tocco A, Cossu P, Pintus C, David E, Mazzucco G, Verme G, Rizzetto M: A randomized controlled trial of interferon alfa-2b as therapy for chronic non-A, non-B hepatitis. J Hepatol 11:S43-S49, 1990","journal-title":"J Hepatol"},{"key":"BF02087706_CR24","doi-asserted-by":"crossref","unstructured":"Gretch D, Han J, Willson R, Carithers R, Busch M, Sayers M, Corey L: High titer hepatitis C virus infection is associated with advanced disease state and resistance to interferon therapy. Hepatology 18(4) (pt 2):A125, 1993 (abstract)","DOI":"10.1016\/0270-9139(93)91879-W"},{"key":"BF02087706_CR25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/00003088-198409030-00001","volume":"9","author":"K Wilson","year":"1984","unstructured":"Wilson K: Sex-related differences in drug disposition in man. Clin Pharmacokinet 9:189\u2013202, 1984","journal-title":"Clin Pharmacokinet"},{"issue":"5","key":"BF02087706_CR26","first-page":"126","volume":"38","author":"J Hamilton","year":"1983","unstructured":"Hamilton J, Parry B: Sex-related differences in clinical drug response: Implications for women's health. JAMWA 38(5):126\u2013132, 1983","journal-title":"JAMWA"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02087706.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02087706\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02087706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T01:14:02Z","timestamp":1586394842000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02087706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["BF02087706"],"URL":"https:\/\/doi.org\/10.1007\/bf02087706","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}