{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:14:22Z","timestamp":1791036862488,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[1994,8,1]],"date-time":"1994-08-01T00:00:00Z","timestamp":775699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1994,8]]},"DOI":"10.1007\/bf02087770","type":"journal-article","created":{"date-parts":[[2005,8,14]],"date-time":"2005-08-14T08:36:12Z","timestamp":1124008572000},"page":"1642-1648","source":"Crossref","is-referenced-by-count":108,"title":["An evaluation of antimicrobial treatment for whipple's disease"],"prefix":"10.1007","volume":"39","author":[{"given":"Gerhard E.","family":"Feurle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Marth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF02087770_CR1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199207303270501","volume":"327","author":"DA Relman","year":"1992","unstructured":"Relman DA, Schmidt TM, MacDermott RP, Falkow S: Identification of the uncultured bacillus of Whipple's disease. N Engl J Med 327:293\u2013301, 1992","journal-title":"N Engl J Med"},{"key":"BF02087770_CR2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0016-5085(19)36367-X","volume":"22","author":"JW Paulley","year":"1952","unstructured":"Paulley JW: A case of Whipple's disease (intestinal lipodystrophy). Gastroenterology 22:128\u2013133, 1952","journal-title":"Gastroenterology"},{"key":"BF02087770_CR3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1001\/jama.1966.03100060116030","volume":"195","author":"JM Ruffin","year":"1966","unstructured":"Ruffin JM, Kurtz SM, Roufail WM: Intestinal lipodystrophy (Whipple's disease)\u2014the immediate and prolonged effect of antibiotic therapy. JAMA 195:182\u2013184, 1966","journal-title":"JAMA"},{"key":"BF02087770_CR4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00005792-197005000-00001","volume":"42","author":"H Maizel","year":"1970","unstructured":"Maizel H, Ruffin JM, Dobbins WO III: Whipple's disease: A review of 19 patients from one hospital and a review of the literature since 1950. Medicine 42:175\u2013205, 1970","journal-title":"Medicine"},{"key":"BF02087770_CR5","first-page":"1482","volume-title":"Harrison's Principles of Internal Medicine","author":"P Schur","year":"1991","unstructured":"Schur P: Psoriatic arthritis and arthritis associated with gastrointestinal diseasesIn Harrison's Principles of Internal Medicine, 12th ed. JD Wilson, E Braunwald, KJ Isselbacher, RG Petersdorf, JB Martin, AS Fauci, RK Root (ed). McGraw-Hill, New York, 1991. pp 1482\u20131484","edition":"12th ed."},{"key":"BF02087770_CR6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00004836-199106000-00010","volume":"13","author":"JC Bai","year":"1991","unstructured":"Bai JC, Crosetti EE, Maurino EC, Martinez CA, Sambuelli SA, Boerr LA: Short-term antibiotic treatment in Whipple's disease. J Clin Gastroenterol 13:303\u2013307, 1991","journal-title":"J Clin Gastroenterol"},{"key":"BF02087770_CR7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0025-6196(12)64884-8","volume":"63","author":"JL Fleming","year":"1988","unstructured":"Fleming JL, Wiesner RH, Shorter RG: Whipple's disease: Clinical, biochemical and histopathologic features and assessment of treatment in 29 patients. Mayo Clin Proc 63:539\u2013551, 1988","journal-title":"Mayo Clin Proc"},{"key":"BF02087770_CR8","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/0016-5085(85)90012-5","volume":"88","author":"RD Keinath","year":"1985","unstructured":"Keinath RD, Merrell DE, Vliestra R, Dobbins WO III: Antibiotic treatment and relapse in Whipple's disease. Gastroenterology 88:1867\u20131873, 1985","journal-title":"Gastroenterology"},{"key":"BF02087770_CR9","first-page":"175","volume":"123","author":"DL Knox","year":"1968","unstructured":"Knox DL, Bayless TM, Yardley JH, Charache P: Whipple's disease presenting with ocular inflammation and minimal intestinal symptoms. John Hopkins Med J 123:175\u2013181, 1968","journal-title":"John Hopkins Med J"},{"key":"BF02087770_CR10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00005792-197611000-00003","volume":"55","author":"DL Knox","year":"1976","unstructured":"Knox DL, Bayless TM, Pittman FE: Neurologic disease in patients with treated Whipple's disease. Medicine 55:467\u2013476, 1976","journal-title":"Medicine"},{"key":"BF02087770_CR11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM197904193001607","volume":"300","author":"GE Feurle","year":"1979","unstructured":"Feurle GE, Volk B, Waldherr R: Cerebral Whipple's disease with negative jejunal histology. N Engl J Med 300:907\u2013908, 1979","journal-title":"N Engl J Med"},{"key":"BF02087770_CR12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/jac\/4.3.203","volume":"4","author":"RWA Barling","year":"1978","unstructured":"Barling RWA, Selkon JB: The penetration of antibiotics into cerebrospinal fluid and brain tissue. J Antimicrobiol Chemother 4:203\u2013227, 1978","journal-title":"J Antimicrobiol Chemother"},{"key":"BF02087770_CR13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/jac\/11.4.385","volume":"11","author":"EEL Wang","year":"1983","unstructured":"Wang EEL, Prober CG: Ventricular cerebrospinal fluid concentrations of trimethoprim-sulfamethoxazole. J Antimicrobiol Chemother 11:385\u2013389, 1983","journal-title":"J Antimicrobiol Chemother"},{"key":"BF02087770_CR14","first-page":"85","volume-title":"Handbuch der Inneren Medizin Bd. III\/3","author":"GE Feurle","year":"1983","unstructured":"Feurle GE: Morbus Whipple. Handbuch der Inneren Medizin Bd. III\/3. B. D\u00fcnndarm. Berlin, Springer-Verlag, 1983, pp 85\u2013104"},{"key":"BF02087770_CR15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.0954-6820.1975.tb19519.x","volume":"198","author":"L Elsborg","year":"1975","unstructured":"Elsborg L, Gravgaard E, Jacobson NO: Treatment of Whipple's disease with sulfamethoxazole-trimethoprim. Acta Med Scand 198:141\u2013143, 1975","journal-title":"Acta Med Scand"},{"key":"BF02087770_CR16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.0954-6820.1978.tb08466.x","volume":"204","author":"P Tauris","year":"1978","unstructured":"Tauris P, Moesner J: Whipple's disease\u2014clinical and histopathological changes during treatment with sulfamethoxazole-trimethoprim. Acta Med Scand 204:423\u2013427, 1978","journal-title":"Acta Med Scand"},{"key":"BF02087770_CR17","first-page":"309","volume":"75","author":"AL Viteri","year":"1981","unstructured":"Viteri AL, Greene JF, Chandler JB: Whipple's disease, successful response to sulfamethoxazole-trimethoprim. Am J Gastroenterol 75:309\u2013310, 1981","journal-title":"Am J Gastroenterol"},{"key":"BF02087770_CR18","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0016-5085(84)80126-2","volume":"86","author":"RJ Ryser","year":"1984","unstructured":"Ryser RJ, Locksley RM, Eng SC, Dobbins WO III, Schoenknecht FD, Rubin CE: Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood-brain barrier. Gastroenterology 86:745\u2013752, 1984","journal-title":"Gastroenterology"},{"key":"BF02087770_CR19","first-page":"198","volume":"46","author":"W Kr\u00fccke","year":"1962","unstructured":"Kr\u00fccke W, Stochdorph O: \u00dcber Ver\u00e4nderungen im Zentralnervensystem bei Whipple'scher Krankheit. Verh Dtsch Ges Pathol 46:198\u2013202, 1962","journal-title":"Verh Dtsch Ges Pathol"},{"key":"BF02087770_CR20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S0317167100023556","volume":"7","author":"LR Lapointe","year":"1980","unstructured":"Lapointe LR, Lamarche J, Salloum A, Beaudry R: Meningoependymitis in Whipple's disease. J Can Sci Neurol 7:163\u2013167, 1980","journal-title":"J Can Sci Neurol"},{"key":"BF02087770_CR21","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/jnnp.40.9.901","volume":"40","author":"FCA Romanul","year":"1977","unstructured":"Romanul FCA, Radvany J, Rosales RK: Whipple's disease confined to the brain: A case studied clinically and pathologically. J Neurol Neurosurg 40:901\u2013909, 1977","journal-title":"J Neurol Neurosurg"},{"key":"BF02087770_CR22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00690524","volume":"48","author":"JM Powers","year":"1979","unstructured":"Powers JM, Rawe SE: A neuropathologic study of Whipple's disease. Acta Neuropathol 48:223\u2013226, 1979","journal-title":"Acta Neuropathol"},{"key":"BF02087770_CR23","first-page":"362","volume":"95","author":"MS Simberkoff","year":"1980","unstructured":"Simberkoff MS, Moldover NH, Rahal JJ Jr: Absence of detectable bactericidal and opsonic activities in normal and infected human cerebrospinal fluids: A regional host defense deficiency. J Lab Clin Med 95:362\u2013372, 1980","journal-title":"J Lab Clin Med"},{"key":"BF02087770_CR24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0016-5085(19)33342-6","volume":"63","author":"FF Martin","year":"1972","unstructured":"Martin FF, Vilseck J, Dobbins WO III, Buckley CE, Tyor MP: Immunological alteration in patients with treated Whipple's disease. Gastroenterology 63:6\u201318, 1972","journal-title":"Gastroenterology"},{"key":"BF02087770_CR25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2362.1979.tb00901.x","volume":"9","author":"GE Feurle","year":"1979","unstructured":"Feurle GE, D\u00f6rken B, Sch\u00f6pf E, Lenhard V: HLA B27 and defects in the T-cell system in Whipple's disease. Eur J Clin Invest 9:385\u2013389, 1979","journal-title":"Eur J Clin Invest"},{"key":"BF02087770_CR26","first-page":"239","volume":"183","author":"T Marth","year":"1991","unstructured":"Marth T, Feurle GE, Roux M, Meuer SC: Impaired interaction of immunocompetent cells in Whipple's disease. Immunobiology 183:239\u2013240, 1991 (abstract)","journal-title":"Immunobiology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02087770.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02087770\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02087770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:42:14Z","timestamp":1586392934000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02087770"}},"subtitle":["Tetracycline versus trimethoprim-sulfamethoxazole"],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1994,8]]}},"alternative-id":["BF02087770"],"URL":"https:\/\/doi.org\/10.1007\/bf02087770","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}