{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T15:40:27Z","timestamp":1735918827050,"version":"3.32.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1994,2,1]],"date-time":"1994-02-01T00:00:00Z","timestamp":760060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1994,2]]},"DOI":"10.1007\/bf02090201","type":"journal-article","created":{"date-parts":[[2005,8,14]],"date-time":"2005-08-14T16:28:16Z","timestamp":1124036896000},"page":"301-308","source":"Crossref","is-referenced-by-count":1,"title":["Pepsin concentration in gastroduodenal biopsy homogenates in chronic ulcer disease"],"prefix":"10.1007","volume":"39","author":[{"given":"Fabio","family":"Vianello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Di Mario","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Plebani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastianello","family":"Germana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Dal Santo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioacchino","family":"Leandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Dotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano Andrea","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remo","family":"Naccarato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02090201_CR1","first-page":"1","volume":"28","author":"K Ohe","year":"1979","unstructured":"Ohe K, Ueno N, Yokoya, H, Miyoshi A: The activation of pepsinogen inside the gastric mucosa caused by the hydrogen ion back-diffusion during the course of aspirin ulceration. Hiroshima J Med Sci 28:1\u201311, 1979","journal-title":"Hiroshima J Med Sci"},{"key":"BF02090201_CR2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(85)90017-8","volume":"145","author":"TF Ford","year":"1985","unstructured":"Ford TF, Grant D, Austen BM, Hermon-Taylor J: Intramucosal activation of pepsinogens in the pathogenesis of acute gastric erosions and their prevention by the potent semisynthetic amphipatic inhibitor pepstatinyl-glycyl-lysyl-lysine. Clin Chim Acta 145:37\u201347, 1985","journal-title":"Clin Chim Acta"},{"key":"BF02090201_CR3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/BF01338525","volume":"25","author":"SN Joffe","year":"1980","unstructured":"Joffe SN, Roberts NB, Taylor WH, Baron JH: Exogenous and endogenous acid and pepsin in the pathogenesis of duodenal ulcers in the rat. Dig Dis Sci 25:837\u2013841, 1980","journal-title":"Dig Dis Sci"},{"key":"BF02090201_CR4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0016-5085(89)80054-X","volume":"96","author":"IM Samloff","year":"1989","unstructured":"Samloff IM: Peptic ulcer: The many proteinases of aggression. Gastroenterology 96:586\u2013595, 1989","journal-title":"Gastroenterology"},{"key":"BF02090201_CR5","first-page":"181","volume-title":"Peptic Ulcer Disease","author":"R Nagashima","year":"1985","unstructured":"Nagashima R, Samloff IM: Aggressive factors II: Pepsin.In Peptic Ulcer Disease. FP Brooks, S Cohen, RD Soloway (eds). New York, Churchill Livingstone, 1985, pp 181\u2013214"},{"key":"BF02090201_CR6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0016-5085(88)90419-2","volume":"94","author":"P Walker","year":"1988","unstructured":"Walker P, Luther J, Samloff IM, Feldman M: Life events, stress and psychosocial factors in man with peptic ulcer disease II. Relationships with serum pepsinogen concentration, family history of ulcer and behavioral factors. Gastroenterology 94:323\u2013330, 1988","journal-title":"Gastroenterology"},{"key":"BF02090201_CR7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0016-5085(19)32639-3","volume":"69","author":"IM Samloff","year":"1975","unstructured":"Samloff IM, Liebman WM, Panitch NM: Serum group I pepsinogen by radioimmunoassay in control subjects and patients with peptic ulcer. Gastroenterology 69:83\u201390, 1975","journal-title":"Gastroenterology"},{"key":"BF02090201_CR8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0009-9120(83)94279-0","volume":"16","author":"M Plebani","year":"1983","unstructured":"Plebani M, Di Mario F, Vianello F, Giordano A, Masiero M, Lazzaretto M, Farini R, Ceriotti G, Naccarato R: Pepsinogen group I radioimmunoassay and total serum pepsinogen colorimetric determination: A comparative study in normal subjects and in peptic ulcer patients. Clin Biochem 16:20\u201322, 1983","journal-title":"Clin Biochem"},{"key":"BF02090201_CR9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0009-8981(82)90034-1","volume":"126","author":"M Ichinose","year":"1982","unstructured":"Ichinose M, Miki K, Furihata C, Kageyama T, Hayashi R, Niwa H, Oka H, Matsushima T, Talahashi K: Radioimmunoassay of serum group I and group II pepsinogens in normal controls and patients with various disorders. Clin Chim Acta 126:183\u2013191, 1982","journal-title":"Clin Chim Acta"},{"key":"BF02090201_CR10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0009-8981(88)90339-7","volume":"172","author":"F Vianello","year":"1988","unstructured":"Vianello F, Plebani M, Piccoli A, Tessaro P, Di Mario F, Naccarato R, Burlina A: Role of serum pepsinogen in detecting ulcer disease. Clin Chim Acta 172:335\u2013340, 1988","journal-title":"Clin Chim Acta"},{"key":"BF02090201_CR11","first-page":"63","volume":"300","author":"JI Rotter","year":"1979","unstructured":"Rotter JI, Petersen GM, Samloff IM, McConnel RB, Ellis A, Spence MA, Rimoin DL: Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease. Ann Intern Med 300:63\u201365, 1979","journal-title":"Ann Intern Med"},{"key":"BF02090201_CR12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1056\/NEJM197901113000203","volume":"300","author":"JI Rotter","year":"1979","unstructured":"Rotter JI, Sones JW, Samloff IM, Richardson CT, Gursky JM, Walsh JH, Rimoin DL: Duodenal ulcer disease associated with elevated serum pepsinogen I: An inherited autosomal dominant disorder. N Engl J Med 300:63\u201365, 1979","journal-title":"N Engl J Med"},{"key":"BF02090201_CR13","first-page":"1538","volume":"88","author":"GM Petersen","year":"1985","unstructured":"Petersen GM, Lam SK, Samloff IM, Jing J, Rotter JI: Genetic factors predict duodenal ulcer healing. Gastroenterology 88:1538, 1985 (abstract)","journal-title":"Gastroenterology"},{"key":"BF02090201_CR14","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0140-6736(85)92793-X","volume":"1","author":"FI Lee","year":"1985","unstructured":"Lee FI, Samloff IM, Hardmann M: Comparison of tripotassium di-citrato bismuthate tablets with ranitidine in healing and relapse of duodenal ulcers. Lancet 1:1299\u20131301, 1985","journal-title":"Lancet"},{"key":"BF02090201_CR15","first-page":"831","volume":"79","author":"G Battaglia","year":"1984","unstructured":"Battaglia G, Farini R, Di Mario F, Piccoli A, Plebani M, Vianello F, Burlina A, Naccarato R: Recurrence of duodenal ulcer under continuous antisecretory treatment: An approach to the detection of predictive markers. Am J Gastroenterol 79:831\u2013834, 1984","journal-title":"Am J Gastroenterol"},{"key":"BF02090201_CR16","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/0016-5085(86)91110-8","volume":"90","author":"IM Samloff","year":"1986","unstructured":"Samloff IM, Stemmermann GN, Heilbrun LK, Nomura A: Elevated serum pepsinogen I and II levels differ as risk factors for duodenal ulcer and gastric ulcer. Gastroenterology 90:570\u2013576, 1986","journal-title":"Gastroenterology"},{"key":"BF02090201_CR17","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1136\/gut.25.12.1380","volume":"25","author":"CM Habibullah","year":"1984","unstructured":"Habibullah CM, Mujamid Ali M, Ishaq M, Prajad R, Pratap B, Saleem Y: Study of duodenal ulcer disease in 100 families using total serum pepsinogen as a genetic marker. Gut 25:1380\u20131383, 1984","journal-title":"Gut"},{"key":"BF02090201_CR18","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3109\/00365527809181373","volume":"13","author":"HL Waldum","year":"1978","unstructured":"Waldum HL, Burhol PG, Straume BK: Serum group I pepsinogen and gastrin in relation to gastric H+ and pepsin outputs before and after subcutaneous injection of pentagastrin. Scand J Gastroenterol 13:943\u2013946, 1978","journal-title":"Scand J Gastroenterol"},{"key":"BF02090201_CR19","first-page":"185","volume":"32","author":"J Massarat","year":"1985","unstructured":"Massarat J: Serum pepsin as a parameter of gastric acid secretion. Hepatogastroenterology 32:185\u2013190, 1985","journal-title":"Hepatogastroenterology"},{"key":"BF02090201_CR20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/gut.27.3.243","volume":"27","author":"JP Pearson","year":"1986","unstructured":"Pearson JP, Ward R, Allen A, Roberts NB, Tylor WM: Mucus degradation by pepsin: Comparison of mucolytic activity of human pepsin 1 and pepsin 3: Implications in peptic ulceration. Gut 27:243\u2013248, 1986","journal-title":"Gut"},{"key":"BF02090201_CR21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/227076a0","volume":"227","author":"WH Taylor","year":"1970","unstructured":"Taylor WH: Pepsins of patients with peptic ulcer. Nature 227:76\u201377, 1970","journal-title":"Nature"},{"key":"BF02090201_CR22","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1136\/gut.21.9.766","volume":"21","author":"V Walker","year":"1980","unstructured":"Walker V, Taylor WH: Pepsin 1 secretion in chronic peptic ulceration. Gut 21:766\u2013771, 1980","journal-title":"Gut"},{"key":"BF02090201_CR23","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1136\/gut.20.11.971","volume":"20","author":"V Walker","year":"1979","unstructured":"Walker V, Taylor WH: Cigarette smoking, chronic peptic ulceration and pepsin 1 secretion. Gut 20:971\u2013976, 1979","journal-title":"Gut"},{"key":"BF02090201_CR24","first-page":"46","volume":"70","author":"JL Achord","year":"1978","unstructured":"Achord JL: Comparison of basal gastric acid and pepsin output in controls vs active peptic ulcer disease. Am J Gastroenterol 70:46\u201349, 1978","journal-title":"Am J Gastroenterol"},{"key":"BF02090201_CR25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0009-8981(82)90243-1","volume":"121","author":"K Miki","year":"1982","unstructured":"Miki K, Ichinose M, Furihata C, Niwa H, Oka H, Oda T, Tatsushima T: Potential peptic activity of pepsinogen of human gastroduodenal mucosa determined by fluorescent microassay method using succinyl-albumin. Clin Chim Acta 121:337\u2013344, 1982","journal-title":"Clin Chim Acta"},{"key":"BF02090201_CR26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0009-8981(82)90358-8","volume":"126","author":"TF Ford","year":"1982","unstructured":"Ford TF, Hermon-Taylor J, Grant DAW: A sensitive fluorimetric assay for simultaneous estimation of pepsin and pepsinogen in gastric mucosa. Clin Chim Acta 126:17\u201323, 1982","journal-title":"Clin Chim Acta"},{"key":"BF02090201_CR27","first-page":"1457","volume":"31","author":"KJ Hengels","year":"1986","unstructured":"Hengels KJ, Heinrich G, Strohmeyer G: Relationship between peptic cells mass, mucosal pepsinogen concentration and pepsinogen secretion in normal gastric mucosa and gastritis. Dig Dis Sci 31:1457, 1986 (abstr)","journal-title":"Dig Dis Sci"},{"issue":"4","key":"BF02090201_CR28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/clinchem\/36.4.682","volume":"36","author":"M Plebani","year":"1990","unstructured":"Plebani M, Di Mario F, Dal Santo P, Faggian D, German\u00e0 B, Vianello F, Naccarato R, Burlina A: Measurement of pepsinogen group I in endoscopic gastroduodenal biopsies. Clin Chem 36(4):682\u2013684, 1990","journal-title":"Clin Chem"},{"key":"BF02090201_CR29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/00365521.1970.12096601","volume":"5","author":"D Berstad","year":"1970","unstructured":"Berstad D: A modified hemoglobin substrate method for the estimation of pepsin in gastric juice. Scand J Gastroenterol 5:343\u2013349, 1970","journal-title":"Scand J Gastroenterol"},{"key":"BF02090201_CR30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MA Bradford","year":"1976","unstructured":"Bradford MA: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013251, 1976","journal-title":"Anal Biochem"},{"key":"BF02090201_CR31","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/BF01477552","volume":"57","author":"T Becker","year":"1979","unstructured":"Becker T, Rapp W: Characterization of human pepsin I obtained from purified gastric pepsinogen II. Klin Wochenschr 57:711\u2013718, 1979","journal-title":"Klin Wochenschr"},{"key":"BF02090201_CR32","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/BF01477553","volume":"57","author":"T Becker","year":"1979","unstructured":"Becker T, Rapp W: Characterization of human pepsin II obtained from purified gastric pepsinogen II. Klin Wochenschr 57:719\u2013724, 1979","journal-title":"Klin Wochenschr"},{"key":"BF02090201_CR33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0016-5085(87)90317-9","volume":"993","author":"IM Samloff","year":"1987","unstructured":"Samloff IM, Taggart RT, Shiraishi T, Branch T, Reid WA, Heath R, Lewis RW, Valler MJ, Ray J: Slow moving proteinase: isolation, characterization and immunohistochemical localization in gastric mucosa. Gastroenterology 993:77\u201384, 1987","journal-title":"Gastroenterology"},{"key":"BF02090201_CR34","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1042\/bj1690617","volume":"169","author":"NB Roberts","year":"1978","unstructured":"Roberts NB, Taylor WH: Isolation and properties of a non-pepsin proteinase from human gastric mucosa. Biochem J 169:617\u2013624, 1978","journal-title":"Biochem J"},{"key":"BF02090201_CR35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/gut.27.3.233","volume":"27","author":"CW Venables","year":"1986","unstructured":"Venables CW: Mucus pepsin and peptic ulcer. Gut 27:233\u2013238, 1986","journal-title":"Gut"},{"key":"BF02090201_CR36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/00365518709168866","volume":"47","author":"G Pals","year":"1987","unstructured":"Pals G, Rasanen V, Meuwissen SGM, Frants RR, Kostense PJ, Eriksson AW: Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen 1. Scand J Clin Lab Invest 47:29\u201333, 1987","journal-title":"Scand J Clin Lab Invest"},{"key":"BF02090201_CR37","first-page":"1","volume-title":"Pepsinogens in Man: Clinical and Genetic Advances","author":"B Foltmann","year":"1985","unstructured":"Foltmann B: Purification, structure and activation of pepsinogen.In Pepsinogens in Man: Clinical and Genetic Advances. J Kreuning, IM Samloff, JI Rotter, AW Eriksson (eds). New York, Alan R Liss, 1985, pp 1\u201313"},{"key":"BF02090201_CR38","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/0016-5085(78)93520-5","volume":"74","author":"LJ Libman","year":"1978","unstructured":"Libman LJ, Samloff IM: Quantitative distribution of pepsinogens I and II in gastric mucosa. Gastroenterology 74:1132, 1978 (abstract)","journal-title":"Gastroenterology"},{"key":"BF02090201_CR39","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3109\/00365528809093916","volume":"23","author":"J Sarosiek","year":"1988","unstructured":"Sarosiek J, Slomiany A, Slomiany BL: Evidence for weakening of gastric mucus integrity byCampylobacter pylori. Scand J Gastroenterol 23:585\u2013590, 1988","journal-title":"Scand J Gastroenterol"},{"key":"BF02090201_CR40","first-page":"793","volume":"7","author":"S Pejre","year":"1983","unstructured":"Pejre S, Di Napoli A, Pelissero A, Sategna Guidetti C: Diagnostic usefulness of serum group I pepsinogen determination. Gastroenterol Clin Biol 7:793\u2013798, 1983","journal-title":"Gastroenterol Clin Biol"},{"key":"BF02090201_CR41","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0009-9120(83)94151-6","volume":"16","author":"M Plebani","year":"1983","unstructured":"Plebani M, Di Mario F, Vianello F, Farini R, Piccoli A, Lazzaretto L, Perobelli L, Naccarato R, Burlina A: Actual role of pepsinogen group I in the study of upper gastrointestinal disease. Clin Biochem 16:310\u2013312, 1983","journal-title":"Clin Biochem"},{"key":"BF02090201_CR42","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0016-5085(19)32149-3","volume":"73","author":"JI Rotter","year":"1977","unstructured":"Rotter JI, Rimoin DL: Peptic ulcer disease\u2014a heterogeneous group of disorders? Gastroenterology 73:604\u2013607, 1977","journal-title":"Gastroenterology"},{"key":"BF02090201_CR43","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0016-5085(24)05133-3","volume":"86","author":"BI Hirschowitz","year":"1984","unstructured":"Hirschowitz BI: Apparent and intrinsic sensitivity to pentagastrin of acid and peptic secretion in peptic ulcer. Gastroenterology 86:843\u2013851, 1984","journal-title":"Gastroenterology"},{"issue":"suppl 78","key":"BF02090201_CR44","first-page":"981","volume":"17","author":"A Malesci","year":"1982","unstructured":"Malesci A, Basilico M, Bonato C, Marchi R, Tittobello A: Smoking and serum pepsinogen I in duodenal ulcer. Scand J Gastroenterol 17(suppl 78):981, 1982","journal-title":"Scand J Gastroenterol"},{"key":"BF02090201_CR45","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/00004836-198608000-00029","volume":"4","author":"A Pelissero","year":"1986","unstructured":"Pelissero A, Di Napoli A, Peyre S, Sategna Guidetti S: Serum group I pepsinogens levels in normal adults. J Clin Gastroenterol 4:499, 1986","journal-title":"J Clin Gastroenterol"},{"key":"BF02090201_CR46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/gut.27.4.433","volume":"27","author":"S Massarrat","year":"1986","unstructured":"Massarrat S, Enschai F, Pittner PM: Increased gastric secretory capacity in smokers without gastro-intestinal lesions. Gut 27:433\u2013439, 1986","journal-title":"Gut"},{"key":"BF02090201_CR47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1136\/gut.12.2.93","volume":"12","author":"HT Debas","year":"1971","unstructured":"Debas HT, Cohen NM, Holubitsky IB, Harrison RC: Effect of cigarette smoking on human gastric secretory responses. Gut 12:93\u201396, 1971","journal-title":"Gut"},{"key":"BF02090201_CR48","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1136\/gut.26.12.1327","volume":"26","author":"F Parente","year":"1985","unstructured":"Parente F, Lazzaroni M, Sangaletti O, Baroni S, Bianchi Porro G: Cigarette smoking, gastric acid secretion and serum pepsinogen I concentrations in duodenal ulcer patients. Gut 26:1327\u20131332, 1985","journal-title":"Gut"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02090201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02090201\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02090201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T15:06:28Z","timestamp":1735916788000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02090201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,2]]}},"alternative-id":["BF02090201"],"URL":"https:\/\/doi.org\/10.1007\/bf02090201","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[1994,2]]}}}