{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:35:51Z","timestamp":1752550551589},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1996,5]]},"DOI":"10.1007\/bf02091529","type":"journal-article","created":{"date-parts":[[2005,8,14]],"date-time":"2005-08-14T16:26:11Z","timestamp":1124036771000},"page":"902-911","source":"Crossref","is-referenced-by-count":10,"title":["Intraepithelial lymphocytes in colon have similar properties to intraepithelial lymphocytes in small intestine and hepatic intermediate TCR cells"],"prefix":"10.1007","volume":"41","author":[{"given":"Kazuo","family":"Ohtsuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yamagiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisami","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Abo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02091529_CR1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/gut.18.11.921","volume":"18","author":"A Ferguson","year":"1977","unstructured":"Ferguson A: Intraepithelial lymphocytes of the small intestine. Gut 18:921\u2013937, 1977","journal-title":"Gut"},{"key":"BF02091529_CR2","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1084\/jem.148.6.1661","volume":"148","author":"D Guy-Grand","year":"1978","unstructured":"Guy-Grand D, Griscelli C, Vassalli P: The mouse gut T lymphocyte, a novel type of T cell. J Exp Med 148:1661\u20131677, 1978","journal-title":"J Exp Med"},{"key":"BF02091529_CR3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/eji.1830200210","volume":"20","author":"B Geus De","year":"1990","unstructured":"De Geus B, Van den Enden M, Coolen C, Nagelkerken L, Van der Heijden P, Rozing J: Phenotype of intraepithelial lymphocytes in euthymic and athymic mice:implications for differentiation of cells bearing a CD3-associated \u03b3\u03b4 T cell receptor. Eur J Immunol 20:291\u2013298, 1990","journal-title":"Eur J Immunol"},{"key":"BF02091529_CR4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1073\/pnas.88.1.43","volume":"88","author":"A Bandeira","year":"1991","unstructured":"Bandeira A, Itohara S, Bonneville M, Burlen-Defranoux O, Mota-Santos T, Coutinho A, Tonegawa S: Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor \u03b3\u03b4. Proc Natl Acad Sci USA 88:43\u201347, 1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02091529_CR5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1084\/jem.173.2.471","volume":"173","author":"D Guy-Grand","year":"1991","unstructured":"Guy-Grand D, Cerf-Bensussan N, Malissen B, Malassis-Seris M, Briottet C, Vassalli P: Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: A role for the gut epithelium in T cell differentiation. J Exp Med 173:471\u2013481, 1991","journal-title":"J Exp Med"},{"key":"BF02091529_CR6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1084\/jem.173.2.483","volume":"173","author":"B Rocha","year":"1991","unstructured":"Rocha B, Vassalli P, Guy-Grand D: The V\u03b2 repertoire of mouse gut homodimeric \u03b1CD8+ intraepithelial T cell receptor \u03b1\/\u03b2+ lymphocyte reveals a major extrathymic pathway of T cell differentiation. J Exp Med 173:483\u2013486, 1991","journal-title":"J Exp Med"},{"key":"BF02091529_CR7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0167-5699(92)90074-H","volume":"13","author":"B Rocha","year":"1992","unstructured":"Rocha B, Vassali P, Guy-Grand D: The extrathymic T-cell development pathway. Immunol Today 13:449\u2013454, 1992","journal-title":"Immunol Today"},{"key":"BF02091529_CR8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/cimm.1994.1005","volume":"153","author":"K Ohtsuka","year":"1994","unstructured":"Ohtsuka K, Iiai T, Watanabe H, Tanaka T, Miyasaka M, Sato K, Asakura H, Abo T: Similarities and differences between extrathymic T cells residing in mouse liver and intestine. Cell Immunol 153:52\u201366, 1994","journal-title":"Cell Immunol"},{"key":"BF02091529_CR9","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.4049\/jimmunol.147.6.1746","volume":"147","author":"L Lefrancois","year":"1991","unstructured":"Lefrancois L: Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J Immunol 147:1746\u20131751, 1991","journal-title":"J Immunol"},{"key":"BF02091529_CR10","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.4049\/jimmunol.149.5.1562","volume":"149","author":"T Ohteki","year":"1992","unstructured":"Ohteki T, Okuyama R, Seki S, Abo T, Sugiura K, Kusumi A, Ohmori T, Watanabe H, Kumagai K: Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice. J Immunol 149:1562\u20131570, 1992","journal-title":"J Immunol"},{"key":"BF02091529_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2220\/biomedres.13.1","volume":"13","author":"T Abo","year":"1992","unstructured":"Abo T: Extrathymic differentiation of T lymphocytes and its biological function. Biomed Res 13:1\u201339, 1992","journal-title":"Biomed Res"},{"key":"BF02091529_CR12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/cimm.1993.1159","volume":"149","author":"H Watanabe","year":"1993","unstructured":"Watanabe H, Iiai T, Kimura M, Ohtsuka K, Tanaka T, Miyasaka M, Tsuchida M, Hanawa H, Abo T: Characterization of intermediate TCR cells in the liver of mice with respect to their unique IL-2R expression. Cell Immunol 149:331\u2013342, 1993","journal-title":"Cell Immunol"},{"key":"BF02091529_CR13","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.4049\/jimmunol.151.4.1765","volume":"151","author":"V Camerini","year":"1993","unstructured":"Camerini V, Panwala C, Kronenberg M: Regional specialization of the mucosal immune system. Intraepithelial lymphocytes of the large intestine have a different phenotype and function than those of the small intestine. J Immunol 151:1765\u20131776, 1993","journal-title":"J Immunol"},{"key":"BF02091529_CR14","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1084\/jem.180.2.433","volume":"180","author":"AR Ibraghimov","year":"1994","unstructured":"Ibraghimov AR, Lynch RG: Heterogeneity and biased T cell receptor \u03b1\/\u03b2 repertoire of mucosal CD8+ cells from murine large intestine: Implications for functional state. J Exp Med 180:433\u2013444, 1994","journal-title":"J Exp Med"},{"key":"BF02091529_CR15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-3083.1995.tb03541.x","volume":"41","author":"G Boll","year":"1995","unstructured":"Boll G, Rudolphi A, Spiess S, Reimann J: Regional specialization of intraepithelial T cells in the murine small and large intestine. Scand J Immunol 41:103\u2013113, 1995","journal-title":"Scand J Immunol"},{"key":"BF02091529_CR16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0022-1759(92)90223-G","volume":"146","author":"H Watanabe","year":"1992","unstructured":"Watanabe H, Ohtsuka K, Kimura M, Ikarashi Y, Ohmori K, Kusumi A, Ohteki T, Seki S, Abo T: Details of an isolation method for hepatic lymphocytes in mice. J Immunol Methods 146:145\u2013154, 1992","journal-title":"J Immunol Methods"},{"key":"BF02091529_CR17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/gut.22.6.481","volume":"22","author":"MDJ Davis","year":"1981","unstructured":"Davis MDJ, Parrott DMV: Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine. Gut 22:481\u2013488, 1981","journal-title":"Gut"},{"key":"BF02091529_CR18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2220\/biomedres.15.281","volume":"15","author":"K Ohtsuka","year":"1994","unstructured":"Ohtsuka K, Kobayashi S, Haga M, Watanabe T, Tomiyama K, Watanabe H, Abo T: Expression of Fas mRNA by liver MNC, consisting of extrathymic T cells, in mice. Biomed Res 15:281\u2013286, 1994","journal-title":"Biomed Res"},{"key":"BF02091529_CR19","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0008-8749(91)90055-G","volume":"137","author":"S Seki","year":"1991","unstructured":"Seki S, Abo T, Sugiura K, Ohteki T, Kobata T, Yagita H, Okumura K, Rikiishi H, Masuda T, Kumagai K: Reciprocal T cell responses in the liver and thymus of mice injected with syngeneic tumor cells. Cell Immunol 137:46\u201360, 1991","journal-title":"Cell Immunol"},{"key":"BF02091529_CR20","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.4049\/jimmunol.145.4.1039","volume":"145","author":"ZK Ballas","year":"1990","unstructured":"Ballas ZK, Rasmussen W: NK1.1+ thymocytes. Adult murine CD4\u2212, CD8\u2212 thymocytes contain an NK1.1+, CD3+ CD5hi, CD44hi, TCR-V\u03b28+ subset. J Immunol 145:1039\u20131045, 1990","journal-title":"J Immunol"},{"key":"BF02091529_CR21","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1073\/pnas.89.14.6506","volume":"89","author":"H Arase","year":"1992","unstructured":"Arase H, Arase N, Ogasawara K, Good RA, Onoe K: An NK1.1+ CD4+8\u2212 single-positive thymocytes subpopulation that express a highly skewed T-cell antigen receptor for V\u03b2 family. Proc Natl Acad Sci USA 89:6506\u20136510, 1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02091529_CR22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.4049\/jimmunol.150.2.447","volume":"150","author":"T Suda","year":"1993","unstructured":"Suda T, Zlotnik A: Origin, differentiation, and repertoire selection of CD3+CD4\u2212CD8\u2212 thymocytes bearing either \u03b1\u03b2 or \u03b3\u03b4 T cell receptors. J Immunol 150:447\u2013455, 1993","journal-title":"J Immunol"},{"key":"BF02091529_CR23","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.4049\/jimmunol.155.6.2972","volume":"155","author":"H Watanabe","year":"1995","unstructured":"Watanabe H, Miyaji C, Kawachi Y, Iiai T, Ohtsuka K, Iwanaga T, Takahashi-Iwanaga H, Abo T: Relationships between intermediate TCR cells and NK1.1+ T cells in various immune organs. NK1.1+ T cells are present within a population of intermediate TCR cells. J Immunol 155:2972\u20132983, 1995","journal-title":"J Immunol"},{"key":"BF02091529_CR24","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1348-0421.1994.tb01840.x","volume":"38","author":"K Ohtsuka","year":"1994","unstructured":"Ohtsuka K, Hasegawa K, Sato K, Arai K, Watanabe H, Asakura H, Abo T: A similar expression pattern of adhesion molecules between intermediate TCR cells in the liver and intraepithelial lymphocytes in the intestine. Microbiol Immunol 38:677\u2013683, 1994","journal-title":"Microbiol Immunol"},{"key":"BF02091529_CR25","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.4049\/jimmunol.150.6.2179","volume":"150","author":"BC Sydora","year":"1993","unstructured":"Sydora BC, Mixter PF, Holcombe HR, Egftesady P, Williams K, Amaral MC, Nel A, Kronenberg M: Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. J Immunol 150:2179\u20132191, 1993","journal-title":"J Immunol"},{"key":"BF02091529_CR26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.iy.09.040191.003525","volume":"9","author":"A Herman","year":"1991","unstructured":"Herman A, Kappler JW, Marrack P, Pullen AM: Superantigens: Mechanism of T-cell stimulation and role in immune responses. Annu Rev Immunol 9:745\u2013772, 1991","journal-title":"Annu Rev Immunol"},{"key":"BF02091529_CR27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/08830189409061717","volume":"11","author":"T Abo","year":"1994","unstructured":"Abo T, Watanabe H, Iiai T, Kimura M, Ohtsuka K, Sato K, Ogawa M, Hirahara H, Hashimoto S, Sekikawa H, Seki S: Extrathymic pathways of T-cell differentiation in the liver and other organs. Int Rev Immunol 11:61\u2013102, 1994","journal-title":"Int Rev Immunol"},{"key":"BF02091529_CR28","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/eji.1830210722","volume":"21","author":"T Ohteki","year":"1991","unstructured":"Ohteki T, Abo T, Seki S, Kobata T, Yagita H, Okumura K, Kumagai K: Predominant appearance of \u03b3\u03b4 T lymphocytes in the liver of mice after birth. Eur J Immunol 21:1733\u20131740, 1991","journal-title":"Eur J Immunol"},{"key":"BF02091529_CR29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/eji.1830220124","volume":"22","author":"H Takimoto","year":"1992","unstructured":"Takimoto H, Nakamura T, Takeuchi M, Sumi Y, Tanaka T, Nomoto K, Yoshikai Y: Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats. Eur J Immunol 22:159\u2013164, 1992","journal-title":"Eur J Immunol"},{"key":"BF02091529_CR30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1084\/jem.176.1.187","volume":"176","author":"P Poussier","year":"1992","unstructured":"Poussier P, Edouard P, Lee C, Binnie M, Julius M: Thymus-independent development and negative selection of T cells expressing T cell receptor \u03b1\/\u03b2 in the intestinal epithelium; evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes. J Exp Med 176:187\u2013199, 1992","journal-title":"J Exp Med"},{"key":"BF02091529_CR31","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1084\/jem.182.3.759","volume":"182","author":"K Sato","year":"1995","unstructured":"Sato K, Ohtsuka K, Hasegawa K, Yamagiwa S, Watanabe H, Abo T: Evidence for extrathymic generation of intermediate TCR cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation. J Exp Med 182:759\u2013767, 1995","journal-title":"J Exp Med"},{"key":"BF02091529_CR32","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev.iy.10.040192.003551","volume":"10","author":"K Ikuta","year":"1992","unstructured":"Ikuta K, Uchida N, Friedman J, Weissman IL: Lymphocyte development from stem cells. Annu Rev Immunol 10:759\u2013783, 1992","journal-title":"Annu Rev Immunol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02091529.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02091529\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02091529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T06:08:57Z","timestamp":1683180537000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02091529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["BF02091529"],"URL":"https:\/\/doi.org\/10.1007\/bf02091529","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}