{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:17:24Z","timestamp":1760188644879},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1994,6,1]],"date-time":"1994-06-01T00:00:00Z","timestamp":770428800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1994,6]]},"DOI":"10.1007\/bf02093790","type":"journal-article","created":{"date-parts":[[2005,8,14]],"date-time":"2005-08-14T14:04:56Z","timestamp":1124028296000},"page":"1249-1256","source":"Crossref","is-referenced-by-count":12,"title":["Misoprostol protection against acetaminophen-induced hepatotoxicity in the rat"],"prefix":"10.1007","volume":"39","author":[{"given":"S.","family":"Ping Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona J.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul E.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02093790_CR1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0090-6980(89)90105-6","volume":"37","author":"BD Rush","year":"1989","unstructured":"Rush BD, Wilkinson KF, Nichols NM, Ochoa R, Brunden MN, Ruwart MJ: Hepatic protection by 16,16-dimethyl prostaglandin E2 (DMPG) against acute aflatoxin B1-induced injury in the rat. Prostaglandins 37:683\u2013693, 1989","journal-title":"Prostaglandins"},{"key":"BF02093790_CR2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/hep.1840090607","volume":"9","author":"W Bursch","year":"1989","unstructured":"Bursch W, Taper HS, Somer MP, Meyer S, Putz B, Schulte-Hermann R: Histochemical and biochemical studies on the effect of the prostacyclin derivative Iloprost on CCl4-induced lipid peroxidation in rat liver and its significance for hepatoprotection. Hepatology 9:830\u2013838, 1989","journal-title":"Hepatology"},{"key":"BF02093790_CR3","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/hep.1840080443","volume":"8","author":"RA Levine","year":"1988","unstructured":"Levine RA: Hepatic cytoprotection by prostaglandins: Theories unlimited. Hepatology 8:969\u2013970, 1988","journal-title":"Hepatology"},{"key":"BF02093790_CR4","first-page":"H176","volume":"238","author":"H Araki","year":"1980","unstructured":"Araki H, Lefer AM: Cytoprotective actions of prostacyclin during hypoxia in the isolated perfused cat liver. Am J Physiol 238:H176-H181, 1980","journal-title":"Am J Physiol"},{"key":"BF02093790_CR5","first-page":"4105","volume":"19","author":"A Alvarez-Lopez","year":"1987","unstructured":"Alvarez-Lopez A, de Hemptinne B, Hoebeke Y, Lambotte L: Prostaglandin E2 increases the tolerance of the rat liver to warm ischemia in absence of splanchnic congestion. Transplant Proc 19:4105\u20134109, 1987","journal-title":"Transplant Proc"},{"key":"BF02093790_CR6","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/BF01296572","volume":"37","author":"SP Lim","year":"1992","unstructured":"Lim SP, Andrews FJ, Christophi C, O'Brien PE: Misoprestol hepatoprotection against ischemia-reperfusion-induced liver injury in the rat. Dig Dis Sci 37:1275\u20131281, 1992","journal-title":"Dig Dis Sci"},{"key":"BF02093790_CR7","first-page":"311","volume":"18","author":"J Stachura","year":"1980","unstructured":"Stachura J, Tarnawski A, Szczudrawa J, Bogdal J, Mach T, Barbara K, Kirchmayer S: Cytoprotective effect of 16,16-dimethyl prostaglandin E2 and some drugs on an acute galactosamine induced liver damage in rat. Folia Histochem Cytochem 18:311\u2013318, 1980","journal-title":"Folia Histochem Cytochem"},{"key":"BF02093790_CR8","unstructured":"Bursch W, Schulte-Hermann R: Cytoprotective effect of the prostacyclin derivative iloprost against liver cell death induced by the hepatotoxins carbon tetrachloride and bromobenzene. Klin Wochenschr 64(suppl VII):47'50, 1986"},{"key":"BF02093790_CR9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0016-5085(81)80049-2","volume":"81","author":"J Stachura","year":"1981","unstructured":"Stachura J, Tarnawski A, Ivey KJ, Mach T, Bogdal J, Szczudrawa J, Klimczyk B: Prostaglandin protection of carbon tetrachloride-induced liver cell necrosis in the rat. Gastroenterology 81:211\u2013217, 1981","journal-title":"Gastroenterology"},{"issue":"suppl","key":"BF02093790_CR10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0090-6980(81)90124-6","volume":"21","author":"MJ Ruwart","year":"1981","unstructured":"Ruwart MJ, Rush BD, Friedle NM, Piper RC, Kolaja GJ: Protective effects of 16,16-dimethyl PGE2 on the liver and kidney. Prostaglandins 21(suppl):97\u2013102, 1981","journal-title":"Prostaglandins"},{"key":"BF02093790_CR11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/hep.1840080210","volume":"8","author":"F Guarner","year":"1988","unstructured":"Guarner F, Boughton-Smith NK, Blackwell GJ: Reduction by prostacyclin of acetaminophen induced liver toxicity in the mouse. Hepatology 8:248\u2013253, 1988","journal-title":"Hepatology"},{"key":"BF02093790_CR12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/15287398509530674","volume":"15","author":"KL Raheja","year":"1985","unstructured":"Raheja KL, Linscheer WG, Cho CD, Coulson R: Failure of exogenous prostaglandin to afford complete protection against acetaminophen-induced hepatotoxicity in the rat. J Toxicol Environ Health 15:477\u2013484, 1985","journal-title":"J Toxicol Environ Health"},{"key":"BF02093790_CR13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1476-5381.1992.tb14268.x","volume":"105","author":"P Nasseri-Sina","year":"1992","unstructured":"Nasseri-Sina P, Fawthrop DJ, Wilson J, Boobis AR, Davis DS: Cytoprotection by iloprost against paracetamol-induced toxicity in Hamster isolated hepatocytes. Br J Pharmacol 105:417\u2013423, 1992","journal-title":"Br J Pharmacol"},{"key":"BF02093790_CR14","unstructured":"Misoprostol (Cytotec). Preclinical and clinical review. Glenview, Illinois, Physicians and Scientists Publishing, 1990"},{"key":"BF02093790_CR15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0009-8981(76)90253-9","volume":"67","author":"M Ohshita","year":"1976","unstructured":"Ohshita M, Takeda H, Kamiyama Y, Ozawa K, Honjo I: A direct method for the estimation of ornithine carbamoyl-transferase activity in serum. Clin Chim Acta 67:145\u2013152, 1976","journal-title":"Clin Chim Acta"},{"key":"BF02093790_CR16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"S Reitman","year":"1957","unstructured":"Reitman S, Frankel S: A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28:56\u201363, 1957","journal-title":"Am J Clin Pathol"},{"key":"BF02093790_CR17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-4800(84)90012-1","volume":"41","author":"WM Frederiks","year":"1984","unstructured":"Frederiks WM, Fronik GM, Hesseling JMG: A method for quantitative analysis of the extent of necrosis in ischemic rat liver. Exp Mol Pathol 41:119\u2013125, 1984","journal-title":"Exp Mol Pathol"},{"key":"BF02093790_CR18","first-page":"185","volume":"187","author":"JR Mitchell","year":"1973","unstructured":"Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB: Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther 187:185\u2013194 1973","journal-title":"J Pharmacol Exp Ther"},{"key":"BF02093790_CR19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","volume":"74","author":"PJ Hissin","year":"1976","unstructured":"Hissin PJ, Hilf R: A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214\u2013226, 1976","journal-title":"Anal Biochem"},{"key":"BF02093790_CR20","first-page":"181","volume":"45","author":"M Davis","year":"1976","unstructured":"Davis M, Simmons CJ, Harrison NG, Williams R: Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage. Q J Med 45:181\u2013191, 1976","journal-title":"Q J Med"},{"key":"BF02093790_CR21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1055\/s-2008-1040597","volume":"6","author":"M Davis","year":"1986","unstructured":"Davis M: Protective agents for acetaminophen overdose. Semin Liver Dis 6:138\u2013147, 1986","journal-title":"Semin Liver Dis"},{"key":"BF02093790_CR22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1136\/bmj.289.6439.217","volume":"289","author":"TGK Mant","year":"1984","unstructured":"Mant TGK, Tempowski JH, Volans GN, Talbot JCC: Adverse reactions to acetylcysteine and effects of overdose. Br Med J 289:217\u2013219, 1984","journal-title":"Br Med J"},{"key":"BF02093790_CR23","first-page":"321","volume":"113","author":"RM Walker","year":"1983","unstructured":"Walker RM, Racz WJ, McElligott TF: Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice. Am J Pathol 113:321\u2013330, 1983","journal-title":"Am J Pathol"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02093790.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02093790\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02093790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:57:57Z","timestamp":1586393877000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02093790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["BF02093790"],"URL":"https:\/\/doi.org\/10.1007\/bf02093790","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6]]}}}