{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T21:08:03Z","timestamp":1706562483090},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1984,5,1]],"date-time":"1984-05-01T00:00:00Z","timestamp":452217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefe's Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[1984,5]]},"DOI":"10.1007\/bf02134145","type":"journal-article","created":{"date-parts":[[2005,9,14]],"date-time":"2005-09-14T17:06:59Z","timestamp":1126717619000},"page":"234-238","source":"Crossref","is-referenced-by-count":11,"title":["R-Enantiomer of timolol: a potential selective ocular antihypertensive agent"],"prefix":"10.1007","volume":"221","author":[{"given":"Norman N.","family":"Share","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor J.","family":"Lotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Gautheron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis M.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald A.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clement A.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02134145_CR1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1476-5381.1975.tb07328.x","volume":"53","author":"E Adler-Graschinsky","year":"1975","unstructured":"Adler-Graschinsky E, Langer SZ (1975) Possible role of a \u03b2-adrenoceptor in the regulation of noreadrenaline release by nerve stimulation through a positive feed-back mechanism. Br J Pharmacol 53:43\u201350","journal-title":"Br J Pharmacol"},{"key":"BF02134145_CR2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.2042-7158.1970.tb08443.x","volume":"22","author":"AM Barrett","year":"1970","unstructured":"Barrett AM, Nunn B (1970) Adrenergic neuron blocking properties of (\u00b1)-propranolol and (+)-propranolol. J Pharm Pharmacol 22:806\u2013810","journal-title":"J Pharm Pharmacol"},{"key":"BF02134145_CR3","first-page":"203","volume":"19","author":"BB Bromberg","year":"1980","unstructured":"Bromberg BB, Gregory DS, Sears ML (1980) \u03b2-Adrenergic receptors in ciliary processes of the rabbit. Invest Ophthalmol Vis Sci 19:203\u2013207","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF02134145_CR4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-4835(81)90034-8","volume":"32","author":"J Cepelik","year":"1981","unstructured":"Cepelik J, Cernohorsky M (1981) The effects of adrenergic agonists and antagonists on the adenylate cyclase in albino rabbit ciliary processes. Exp Eye Res 32:291\u2013299","journal-title":"Exp Eye Res"},{"key":"BF02134145_CR5","first-page":"507","volume":"2","author":"GCY Chiou","year":"1983","unstructured":"Chiou GCY (1983) Effects of D-timolol on intraocular pressure, heart rate, cardiac contractility and tracheal muscle function. Current Eye Res 2:507\u2013510","journal-title":"Current Eye Res"},{"key":"BF02134145_CR6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0014-4835(79)90050-2","volume":"29","author":"Z Dafna","year":"1979","unstructured":"Dafna Z, Lahav M, Melamed E (1979) Localization of \u03b2-adrenoceptors in the anterior segment of the albino rabbit eye using a fluorescent analog of propranolol. Exp Eye Res 29: 327\u2013330","journal-title":"Exp Eye Res"},{"key":"BF02134145_CR7","first-page":"201","volume-title":"Chemical tools in catecholamine research. II. Regulation of catecholamine turnover","author":"C Dahlof","year":"1975","unstructured":"Dahlof C, Ablad B, Borg KO, Ek L, Waldeck B (1975) Prejunctional inhibition of adrenergic nervous vasomotor control due to \u03b2-receptor blockade. In: Almgren O, Carlsson A, Engel J (eds) Chemical tools in catecholamine research. II. Regulation of catecholamine turnover. North-Holland\/American Elsevier, New York, pp 201\u2013210"},{"key":"BF02134145_CR8","doi-asserted-by":"crossref","unstructured":"Day MD, Owen DAA, Warren PR (1968) An adrenergic neuron blocking action of propranolol in isolated tissues. J Pharm Pharmacol 20:130S\u2013134S","DOI":"10.1111\/j.2042-7158.1968.tb09874.x"},{"key":"BF02134145_CR9","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1021\/ac60052a025","volume":"23","author":"RB Dean","year":"1951","unstructured":"Dean RB, Dixon WJ (1951) Simplified statistics for small numbers of observations. Anal Chem 23:636\u2013638","journal-title":"Anal Chem"},{"key":"BF02134145_CR10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2307\/2528490","volume":"20","author":"CW Dunnett","year":"1964","unstructured":"Dunnett CW (1964) New tables for multiple comparisons with a control. Biometrics 20: 482\u2013491","journal-title":"Biometrics"},{"key":"BF02134145_CR11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1476-5381.1971.tb08059.x","volume":"43","author":"S Eliash","year":"1971","unstructured":"Eliash S, Weinstock M (1971) Role of adrenergic neurone blockade in the hypotensive action of propranolol. Br J Pharmacol 43:287\u2013294","journal-title":"Br J Pharmacol"},{"key":"BF02134145_CR12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF00508291","volume":"305","author":"S Guimaraes","year":"1978","unstructured":"Guimaraes S, Brando F, Paira MQ (1978) A study of the adrenoceptor-mediated feedback mechanisms by using adrenaline as a false transmitter. Naunyn Schmiedebergs Arch Pharmacol 305: 185\u2013188","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"BF02134145_CR13","first-page":"329","volume":"199","author":"HH Harms","year":"1976","unstructured":"Harms HH (1976) Isoproterenol antagonism of caudioselective \u03b2-adrenergic receptor blocking agents: a comparative study of human and guinea-pig cardiac and bronchial \u03b2-adrenergic receptors. J Pharmacol Exp Ther 199:329\u2013335","journal-title":"J Pharmacol Exp Ther"},{"key":"BF02134145_CR14","first-page":"133","volume-title":"Central actions of drugs in blood pressure regulation","author":"SZ Langer","year":"1975","unstructured":"Langer SZ, Enero MA, Adler-Graschinsky E, Dubocovich ML, Celuchi SM (1975) Presynaptic regulatory mechanisms for noradrenaline release by nerve stimulation. In: Davies DS, Reid JL (eds) Central actions of drugs in blood pressure regulation. University Park Press, Baltimore, pp 133\u2013150"},{"key":"BF02134145_CR15","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/01.HYP.2.4.372","volume":"2","author":"SZ Langer","year":"1980","unstructured":"Langer SZ, Cavero I, Massingham R (1980) Recent developments in nor-adrenergic neurotransmission and its relevance to the mechanism of action of certain antihypertensive agents. Hypertension 2:372\u2013382","journal-title":"Hypertension"},{"key":"BF02134145_CR16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0014-4835(81)80007-3","volume":"32","author":"HK Liu","year":"1981","unstructured":"Liu HK, Chiou GCY (1981) Continuous, simultaneous and instant display of aqueous humor dynamics with a micro-spectrophotometer and a sensitive drop counter. Exp Eye Res 32:583\u2013592","journal-title":"Exp Eye Res"},{"key":"BF02134145_CR17","first-page":"1276","volume":"24","author":"JHK Liu","year":"1983","unstructured":"Liu JHK, Bartels SP, Neufeld AH (1983) Effects of 1- and d-timolol on cyclic AMP synthesis and intraocular pressure in water-loaded, albino and pigmented rabbits. Invest Ophthalmol Vis Sci 24:1276\u20131282","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF02134145_CR18","first-page":"311","volume":"12","author":"B Ljung","year":"1975","unstructured":"Ljung B, Abland B, Dahlof C, Henning M, Hultberg E (1975) Impaired vasoconstrictor nerve function in spontaneously hypertensive rats after long-term treatment with propranolol and metroprolol. Blood Ves 12:311\u2013315","journal-title":"Blood Ves"},{"key":"BF02134145_CR19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosenbrough NH, Farr AL, Fandall R (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"BF02134145_CR20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.2042-7158.1973.tb10627.x","volume":"25","author":"EJ Mylecharane","year":"1973","unstructured":"Mylecharane EJ, Raper C (1973) Further studies on the adrenergic neuron blocking activity of some \u03b2-adrenoceptor antagonists and guanethidine. J Pharm Pharmacol 25:213\u2013220","journal-title":"J Pharm Pharmacol"},{"key":"BF02134145_CR21","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.1073\/pnas.77.12.7420","volume":"77","author":"JA Nathanson","year":"1980","unstructured":"Nathanson JA (1980) Adrenergic regulation of intraocular pressure: identification of \u03b22-adrenergic-stimulated adenylate cyclase in ciliary process epithelium. Proc Natl Acad Sci 77: 7420\u20137424","journal-title":"Proc Natl Acad Sci"},{"key":"BF02134145_CR22","first-page":"1118","volume":"16","author":"AH Neufeld","year":"1977","unstructured":"Neufeld AH, Page ED (1977) In vitro determination of the ability of drugs to bind to adrenergic receptors. Invest Ophthalmol Vis Sci 16:1118\u20131124","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF02134145_CR23","first-page":"189","volume":"2","author":"HO Schild","year":"1947","unstructured":"Schild HO (1947) pA2, a new scale for the measurement of drug antagonism. Br J Pharmacol 2:189\u2013206","journal-title":"Br J Pharmacol"},{"key":"BF02134145_CR24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0002-9394(74)90744-2","volume":"77","author":"D Sears","year":"1974","unstructured":"Sears D, Sears M (1974) Blood-aqueous barrier and -chymotrypsin glaucoma in rabbits. Am J Ophthalmol 77:378\u2013383","journal-title":"Am J Ophthalmol"},{"key":"BF02134145_CR25","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0014-4835(70)80061-6","volume":"9","author":"J Vale","year":"1970","unstructured":"Vale J, Phillips CI (1970) Effect ofdl- andd-propranolol on ocular tension in rabbits and patients. Exp Eye Res 9:82\u201390","journal-title":"Exp Eye Res"},{"key":"BF02134145_CR26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000265135","volume":"13","author":"P Vareilles","year":"1981","unstructured":"Vareilles P, Lotti VJ (1981) Effects of timolol on aqueous humor dynamics in the rabbit. Ophthalmic Res 13:72\u201379","journal-title":"Ophthalmic Res"},{"key":"BF02134145_CR27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0014-4835(77)90149-X","volume":"24","author":"P Vareilles","year":"1977","unstructured":"Vareilles P, Conquet Ph, LeDouarec JC (1977a) A method for the routine intraocular pressure (IOP) measurement in the rabbit: range of IOP variations in this species. Exp Eye Res 24: 369\u2013375","journal-title":"Exp Eye Res"},{"key":"BF02134145_CR28","first-page":"987","volume":"16","author":"P Vareilles","year":"1977","unstructured":"Vareilles P, Silverstone D, Plazonnet B, LeDouarec JC, Sears M, Stone CA (1977b) Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit. Invest Ophthalmol Vis Sci 16:987\u2013996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BF02134145_CR29","first-page":"561","volume":"2","author":"P Vareilles","year":"1979","unstructured":"Vareilles P, Durand G, Siou G, LeDouarec JC (1979) Le modele de glaucome experimental a l'alpha-chymotrypsin chez le lapin: Etude histologique. J Fr Ophthalmol 2:561\u2013568","journal-title":"J Fr Ophthalmol"},{"key":"BF02134145_CR30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0039-6257(79)90228-5","volume":"23","author":"TJ Zimmerman","year":"1979","unstructured":"Zimmerman TJ, Boger WP III (1979) The \u03b2-adrenergic blocking agents and the treatment of glaucoma. Surv Ophthalmol 23:347\u2013362","journal-title":"Surv Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02134145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02134145\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02134145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T20:15:06Z","timestamp":1706559306000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02134145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1984,5]]}},"alternative-id":["BF02134145"],"URL":"https:\/\/doi.org\/10.1007\/bf02134145","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}