{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:55:25Z","timestamp":1785858925008,"version":"3.56.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1007\/bf02234828","type":"journal-article","created":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T03:04:41Z","timestamp":1129863881000},"page":"93-97","source":"Crossref","is-referenced-by-count":86,"title":["Glyceryl trinitrate vs. lateral sphincterotomy for chronic anal fissure"],"prefix":"10.1097","volume":"44","author":[{"given":"Justin","family":"Evans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Luck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hewett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02234828_CR1","first-page":"170","volume-title":"Surgery of the anus, rectum and colon","author":"J Goligher","year":"1984","unstructured":"Goligher J. Surgery of the anus, rectum and colon. London: Balliere Tindall 1984;170\u201391."},{"key":"BF02234828_CR2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF00341183","volume":"8","author":"E Xynos","year":"1993","unstructured":"Xynos E, Tzortzinis, Chrysos E,et al. Anal manometry in patients with fissure-in-ano before and after internal sphincterotomy. Int J Colorectal Dis 1993;8:125\u20138.","journal-title":"Int J Colorectal Dis"},{"key":"BF02234828_CR3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/BF02076185","volume":"37","author":"R Farouk","year":"1994","unstructured":"Farouk R, Duthie GS, MacGregor AB, Bartolo DC. Sustained internal sphincter hypertonia in patients with chronic anal fissure. Dis Colon Rectum 1994;37:424\u20139.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF02554725","volume":"32","author":"B Klosterhalfen","year":"1989","unstructured":"Klosterhalfen B, Vogel P, Rixen H, Mittermayer C. Topography of the inferior rectal artery: a possible cause of chronic, primary anal fissure. Dis Colon Rectum 1989;32:43\u201352.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/bjs.1800830120","volume":"83","author":"WR Schouten","year":"1996","unstructured":"Schouten WR, Briel JW, Auwerda JJ, De Graaf EJ. Ischaemic nature of anal fissure. Br J Surg 1996;83:63\u20135.","journal-title":"Br J Surg"},{"key":"BF02234828_CR6","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/BF02054409","volume":"37","author":"WR Schouten","year":"1994","unstructured":"Schouten WR, Briel JW, Auwerda JJ. Relationship between anal pressure and anodermal blood flow: the vascular pathogenesis of anal fissures. Dis Colon Rectum 1994;37:664\u20139.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR7","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/bjs.1800831006","volume":"83","author":"JN Lund","year":"1996","unstructured":"Lund JN, Scholefield JH. Aetiology and treatment of anal fissure. Br J Surg 1996;83:1335\u201344.","journal-title":"Br J Surg"},{"key":"BF02234828_CR8","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/BF02048025","volume":"38","author":"N Williams","year":"1995","unstructured":"Williams N, Scott NA, Irving MH. Effect of lateral sphincterotomy on internal anal sphincter function: a computerized vector manometry study. Dis Colon Rectum 1995;38:700\u20134.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR9","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF02564886","volume":"31","author":"TH Lewis","year":"1988","unstructured":"Lewis TH, Corman ML, Prager ED, Robertson WG. Long-term results of open and closed sphincterotomy for anal fissure. Dis Colon Rectum 1988;31:368\u201371.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR10","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/bmj.3.5724.673","volume":"3","author":"DC Hoffmann","year":"1970","unstructured":"Hoffmann DC, Goligher JC. Lateral subcutaneous internal sphincterotomy in treatment of anal fissure. BMJ 1970;3:673\u20135.","journal-title":"BMJ"},{"key":"BF02234828_CR11","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/BF02586402","volume":"21","author":"RV Bailey","year":"1978","unstructured":"Bailey RV, Rubin RJ, Salvati EP. Lateral internal sphincterotomy. Dis Colon Rectum 1978;21:584\u20136.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR12","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/BF02257799","volume":"37","author":"BJ Pernikoff","year":"1994","unstructured":"Pernikoff BJ, Eisenstat TE, Rubin RJ, Oliver GC, Salvati EP. Reappraisal of partial lateral internal sphincterotomy. Dis Colon Rectum 1994;37:1291\u201395.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR13","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/BF02555487","volume":"28","author":"WA Walker","year":"1985","unstructured":"Walker WA, Rothenberger DA, Goldberg SM. Morbidity of internal sphincterotomy for anal fissure and stenosis. Dis Colon Rectum 1985;28:832\u20135.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR14","first-page":"G107","volume":"262","author":"S Rattan","year":"1992","unstructured":"Rattan S, Chadker S. Role of nitric oxide as mediator of internal anal sphincter relaxation. Am J Physiol 1992;262:G107\u201312.","journal-title":"Am J Physiol"},{"key":"BF02234828_CR15","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/bjs.1800830614","volume":"83","author":"SJ Watson","year":"1996","unstructured":"Watson SJ, Kamm MA, Nicholls RJ, Phillips RK. Topical glyceryl trinitrate in the treatment of chronic anal fissure. Br J Surg 1996;83:771\u20135.","journal-title":"Br J Surg"},{"key":"BF02234828_CR16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/gut.39.3.465","volume":"39","author":"WR Schouten","year":"1996","unstructured":"Schouten WR, Briel JW, Boerma MO,et al. Pathophysiological aspects and clinical outcome of intra-anal application of isosorbide dinitrate in patients with chronic anal fissure Gut 1996;39:465\u20139.","journal-title":"Gut"},{"key":"BF02234828_CR17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0140-6736(96)06090-4","volume":"349","author":"JN Lund","year":"1997","unstructured":"Lund JN, Scholefield JH. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 1997;349:11\u20134.","journal-title":"Lancet"},{"key":"BF02234828_CR18","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/BF02055444","volume":"40","author":"H Bacher","year":"1997","unstructured":"Bacher H, Mischinger HJ, Wergartner G,et al. Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? Dis Colon Rectum 1997;40:840\u20135.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02148842","volume":"38","author":"SR Gorfine","year":"1995","unstructured":"Gorfine SR. Treatment of benign anal disease with topical nitroglycerin. Dis Colon Rectum 1995;38:453\u20137.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR20","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/bjs.1800810949","volume":"81","author":"PB Loder","year":"1994","unstructured":"Loder PB, Kamm, Nicholls RJ, Phillips RK. Reversible chemical sphincterotomy by local application of glyceryl trinitrate. Br J Surg 1994;81:1386\u20139.","journal-title":"Br J Surg"},{"key":"BF02234828_CR21","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/bjs.1800830615","volume":"83","author":"JN Lund","year":"1996","unstructured":"Lund JN, Armitage NC, Scholefield JH. Use of glyceryl trinitrate ointment in the treatment of anal fissure. Br J Surg 1996;83:776\u20137.","journal-title":"Br J Surg"},{"key":"BF02234828_CR22","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1007\/BF02050816","volume":"40","author":"GJ Oettle","year":"1997","unstructured":"Oettle GJ. Glyceryl trinitratevs. sphincterotomy for treatment of chronic fissure-in-ano: a randomized, controlled trial. Dis Colon Rectum 1997;40:1318\u201320.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR23","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/gut.44.5.727","volume":"44","author":"EA Carapeti","year":"1999","unstructured":"Carapeti EA, Kamm MA, McDonald PJ,et al. Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate. Gut 1999;44:727\u201330.","journal-title":"Gut"},{"key":"BF02234828_CR24","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/bjs.1800831006","volume":"83","author":"JN Lund","year":"1996","unstructured":"Lund JN, Scholefield JH. Aetiology and treatment of anal fissure. BJS 1996;83:1335\u201344.","journal-title":"BJS"},{"key":"BF02234828_CR25","first-page":"235","volume":"41","author":"PF Mason","year":"1996","unstructured":"Mason PF, Watkins JG, Hall HS, Hall AW. The management of chronic fissure-in-ano with botulinum toxin. J R Coll Surg Edinb 1996;41:235\u20138.","journal-title":"J R Coll Surg Edinb"},{"key":"BF02234828_CR26","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/BF02050924","volume":"40","author":"WH Jost","year":"1997","unstructured":"Jost WH. One hundred cases of anal fissure treated with botulinum toxin: early and long term results. Dis Colon Rectum 1997;40:1029\u201332.","journal-title":"Dis Colon Rectum"},{"key":"BF02234828_CR27","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/00000658-199811000-00005","volume":"228","author":"G Maria","year":"1998","unstructured":"Maria G, Brisinda, Bentivoglio AR,et al. Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure. Long term results after 2 different dosage regimens. Ann Surg 1998;228:664\u20139.","journal-title":"Ann Surg"},{"key":"BF02234828_CR28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJM199801223380402","volume":"338","author":"G Maria","year":"1998","unstructured":"Maria G, Cassetta E, Gui D,et al. Comparison of botulinum toxin and saline for the treatment of chronic anal fissure. N Engl J Med 1998;338:217\u201320.","journal-title":"N Engl J Med"},{"key":"BF02234828_CR29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJM199907083410201","volume":"341","author":"G Brisinda","year":"1999","unstructured":"Brisinda G, Maria G, Bentivoglio AR,et al. A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. N Engl J Med 1999;341:65\u20139.","journal-title":"N Engl J Med"}],"container-title":["Diseases of the Colon &amp; Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1007\/BF02234828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:59:40Z","timestamp":1785855580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-200144010-00019"}},"subtitle":["Prospective, randomized trial"],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02234828","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}