{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:57:14Z","timestamp":1785859034243,"version":"3.56.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,3]]},"DOI":"10.1007\/bf02236358","type":"journal-article","created":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T23:41:51Z","timestamp":1129851711000},"page":"383-385","source":"Crossref","is-referenced-by-count":69,"title":["Nitroglycerin ointment for anal fissures"],"prefix":"10.1097","volume":"42","author":[{"given":"Neil H.","family":"Hyman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Cataldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02236358_CR1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0016-5085(19)32882-3","volume":"67","author":"BJ Nothmann","year":"1974","unstructured":"Nothmann BJ, Schuster MM. Internal anal sphincter derangements with anal fissures. Gastroenterology 1974;67:216\u201320.","journal-title":"Gastroenterology"},{"key":"BF02236358_CR2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1136\/gut.34.5.689","volume":"34","author":"T O'Kelly","year":"1993","unstructured":"O'Kelly T, Brading A, Mortensen N. Nerve mediated relaxation of the human internal sphincter: the role of nitric oxide. Gut 1993;34:689\u201393.","journal-title":"Gut"},{"key":"BF02236358_CR3","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/bjs.1800830614","volume":"83","author":"SJ Watson","year":"1996","unstructured":"Watson SJ, Kamm MA, Nicholls RJ, Phillips RK. Topical glyceryl trinitrate in the treatment of chronic anal fissure. Br J Surg 1996;83:771\u20135.","journal-title":"Br J Surg"},{"key":"BF02236358_CR4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0140-6736(96)06090-4","volume":"349","author":"JN Lund","year":"1997","unstructured":"Lund JN, Scholefield JH. A randomized, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 1997;349:11\u20134.","journal-title":"Lancet"},{"key":"BF02236358_CR5","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/gut.39.3.465","volume":"39","author":"WR Schouten","year":"1996","unstructured":"Schouten WR, Briel JW, Boerma MD, Auwerda JJ, Wilms EB, Graatsma BH. Pathophysiologic aspects and clinical outcome of intra-anal application of isosorbide dinitrate in patients with chronic anal fissure. Gut 1996;39:465\u20139.","journal-title":"Gut"},{"key":"BF02236358_CR6","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1056\/NEJM199510263331718","volume":"333","author":"SR Gorfine","year":"1995","unstructured":"Gorfine SR. Topical nitroglycerin therapy for anal fissures and ulcers. N Engl J Med 1995;333:1156\u20137.","journal-title":"N Engl J Med"},{"key":"BF02236358_CR7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF02054225","volume":"38","author":"C Oh","year":"1995","unstructured":"Oh C, Divino CM, Steinhagen RM. Anal fissure: 20-year experience. Dis Colon Rectum 1995;38:378\u201382.","journal-title":"Dis Colon Rectum"},{"key":"BF02236358_CR8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/gut.7.2.190","volume":"7","author":"H Magee","year":"1966","unstructured":"Magee H, Thompson H. Internal anal sphincterotomy as an outpatient operation. Gut 1966;7:190\u20132.","journal-title":"Gut"},{"key":"BF02236358_CR9","first-page":"435","volume":"161","author":"DM Neufeld","year":"1995","unstructured":"Neufeld DM, Paran H, Bendahan J, Freund U. Outpatient surgical treatment of anal fissure. Eur J Surg 1995;161:435\u20138.","journal-title":"Eur J Surg"},{"key":"BF02236358_CR10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF02050683","volume":"35","author":"L Rosen","year":"1992","unstructured":"The Standards Task Force, American Society of Colon and Rectal Surgeons. Rosen L, Abel ME Gordon PH,et al. Practice parameters for the management of anal fissure. Dis Colon Rectum 1992;35:206\u20138.","journal-title":"Dis Colon Rectum"},{"key":"BF02236358_CR11","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF02564886","volume":"31","author":"TH Lewis","year":"1988","unstructured":"Lewis TH, Corman ML, Prager ED, Robertson WG. Long-term results of open and closed sphincterotomy for anal fissure. Dis Colon Rectum 1988;31:368\u201371.","journal-title":"Dis Colon Rectum"},{"key":"BF02236358_CR12","first-page":"24","volume":"8","author":"TD Arnell","year":"1997","unstructured":"Arnell TD, Stamos MJ. Sphincterotomy for anal fissure. Semin Colon Rectal Surg 1997;8:24\u20138.","journal-title":"Semin Colon Rectal Surg"},{"key":"BF02236358_CR13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02148842","volume":"38","author":"SR Gorfine","year":"1995","unstructured":"Gorfine SR. Treatment of benign anal disease with topical nitroglycerin. Dis Colon Rectum 1995;38:453\u20137.","journal-title":"Dis Colon Rectum"},{"key":"BF02236358_CR14","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/BF02055444","volume":"40","author":"H Bacher","year":"1997","unstructured":"Bacher H, Mischinger H-J, Werkgartner G,et al. Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? Dis Colon Rectum 1997:40:840\u20135.","journal-title":"Dis Colon Rectum"}],"container-title":["Diseases of the Colon &amp; Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00003246-200602000-00072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:03:09Z","timestamp":1785855789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-199942030-00017"}},"subtitle":["Effective treatment or just a headache?"],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02236358","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}