{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:57:38Z","timestamp":1785859058777,"version":"3.56.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,8]]},"DOI":"10.1007\/bf02236691","type":"journal-article","created":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T06:39:58Z","timestamp":1129876798000},"page":"1000-1006","source":"Crossref","is-referenced-by-count":139,"title":["Glyceryl trinitrate ointment for the treatment of chronic anal fissure"],"prefix":"10.1097","volume":"42","author":[{"given":"M. L.","family":"Kennedy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sowter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Z.","family":"Lubowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02236691_CR1","first-page":"266","volume":"27","author":"S Eisenhammer","year":"1953","unstructured":"Eisenhammer S. The internal anal sphincter: its surgical importance. S Afr Med J 1953;27:266\u201370.","journal-title":"S Afr Med J"},{"key":"BF02236691_CR2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/bjs.1800640204","volume":"64","author":"BD Hancock","year":"1977","unstructured":"Hancock BD. The internal sphincter and anal fissure. Br J Surg 1977;64:92\u20135.","journal-title":"Br J Surg"},{"key":"BF02236691_CR3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/bjs.1800830120","volume":"83","author":"WR Schouten","year":"1996","unstructured":"Schouten WR, Briel JW, Auwerda JJ, de Graff EJ. Ischaemic nature of anal fissure. Br J Surg 1996;83:63\u20135.","journal-title":"Br J Surg"},{"key":"BF02236691_CR4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1136\/bmj.2.5405.342","volume":"2","author":"JM Watts","year":"1964","unstructured":"Watts JM, Bennett RC, Goligher JC. Stretching of anal sphincters in treatment of fissure in ano. Br Med J 1964;2:342\u20133.","journal-title":"Br Med J"},{"key":"BF02236691_CR5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/bjs.1800580204","volume":"58","author":"MJ Notaras","year":"1971","unstructured":"Notaras MJ. The treatment of anal fissure by lateral subcutaneous internal sphincterotomy. A technique and results. Br J Surg 1971;58:96\u2013100.","journal-title":"Br J Surg"},{"key":"BF02236691_CR6","first-page":"423","volume":"65","author":"ML Kennedy","year":"1995","unstructured":"Kennedy ML, Lubowski DZ, King DW. Chemical sphincterotomy for anal fissure: a new treatment. Aust N Z J Surg 1995;65:423.","journal-title":"Aust N Z J Surg"},{"key":"BF02236691_CR7","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/bjs.1800810949","volume":"81","author":"PB Loder","year":"1994","unstructured":"Loder PB, Kamm MA, Nicholls RJ, Phillips RK. Reversible chemical sphincterotomy by topical application of glyceryl trinitrate. Br J Surg 1994;81:1386\u20139.","journal-title":"Br J Surg"},{"key":"BF02236691_CR8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02148842","volume":"38","author":"SR Gorfine","year":"1995","unstructured":"Gorfine SR. Treatment of benign anal disease with topical nitroglycerin. Dis Colon Rectum 1995;38:453\u20137.","journal-title":"Dis Colon Rectum"},{"key":"BF02236691_CR9","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/bjs.1800830614","volume":"83","author":"SJ Watson","year":"1996","unstructured":"Watson SJ, Kamm MA, Nicholls RJ, Phillips RK. Topical glyceryl trinitrate in the treatment of anal fissure. Br J Surg 1996;83:771\u20135.","journal-title":"Br J Surg"},{"key":"BF02236691_CR10","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/bjs.1800830615","volume":"83","author":"JN Lund","year":"1996","unstructured":"Lund JN, Armitage NC, Scholefield JH. Use of glyceryl trinitrate in the treatment of anal fissure. Br J Surg 1996;83:776\u20137.","journal-title":"Br J Surg"},{"key":"BF02236691_CR11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0140-6736(96)06090-4","volume":"349","author":"JN Lund","year":"1997","unstructured":"Lund JN, Scholefield JH. A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 1997;349:11\u20134.","journal-title":"Lancet"},{"key":"BF02236691_CR12","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/BF02055444","volume":"40","author":"H Bacher","year":"1997","unstructured":"Bacher H, Mischinger H-J, Werkgartner G,et al. Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? Dis Colon Rectum 1997;40:840\u20135.","journal-title":"Dis Colon Rectum"},{"key":"BF02236691_CR13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0002-8703(94)90020-5","volume":"128","author":"NJ Mangione","year":"1994","unstructured":"Mangione NJ, Glasser SP. Phenomenon of nitrate intolerance. Am Heart J 1994;128:137\u201346.","journal-title":"Am Heart J"},{"key":"BF02236691_CR14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2165\/00003495-198223030-00001","volume":"23","author":"U Elkayam","year":"1982","unstructured":"Elkayam U, Aronow WS. Glyceryl trinitrate (nitroglycerin) ointment and Isosorbide dinitrate: a review of their pharmacological properties and therapeutic use. Drugs 1982;23:165\u201394.","journal-title":"Drugs"},{"key":"BF02236691_CR15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0016-5085(19)32882-3","volume":"67","author":"BJ Nothmann","year":"1974","unstructured":"Nothmann BJ, Schuster MM. Internal anal sphincter derangement with anal fissures. Gastroenterology 1974;67:216\u201330.","journal-title":"Gastroenterology"},{"key":"BF02236691_CR16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0016-5085(19)32662-9","volume":"69","author":"MM Schuster","year":"1975","unstructured":"Schuster MM. The riddle of the sphincters. Gastroenterology 1975;69:249\u201362.","journal-title":"Gastroenterology"},{"key":"BF02236691_CR17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/bjs.1800730609","volume":"73","author":"CP Gibbons","year":"1996","unstructured":"Gibbons CP, Read NW. Anal hypertonia in fissures: cause or effect? Br J Surg 1996;73:443\u20135.","journal-title":"Br J Surg"},{"key":"BF02236691_CR18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/bjs.1800731123","volume":"73","author":"NL Chowcat","year":"1986","unstructured":"Chowcat NL, Araujo JG, Boulos PB. Internal sphincterotomy for chronic anal fissure: long term effects on anal pressure. Br J Surg 1986;73:915\u20136.","journal-title":"Br J Surg"}],"container-title":["Diseases of the Colon & Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1007\/BF02236691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:03:20Z","timestamp":1785855800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-199942080-00006"}},"subtitle":["Results of a placebo-controlled trial and long-term follow-up"],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1999]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02236691","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}