{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T21:04:08Z","timestamp":1788642248799,"version":"build-2803163510"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,2]]},"DOI":"10.1007\/bf02237134","type":"journal-article","created":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T10:11:22Z","timestamp":1129889482000},"page":"231-240","source":"Crossref","is-referenced-by-count":59,"title":["Slow-transit constipation"],"prefix":"10.1097","volume":"42","author":[{"given":"Donato F.","family":"Altomare","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Di Ciaula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annacinzia","family":"Amoruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Palasciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Memeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02237134_CR1","unstructured":"Preston DM, Rees LH, Lennard Jones JE. Gynaecological disorders and hyperprolactinaemia in chronic constipation. Gut 1988;24:A480"},{"key":"BF02237134_CR2","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1007\/BF02093603","volume":"41","author":"G Bassotti","year":"1996","unstructured":"Bassotti G, Stanghellini V, Chiarioni G,et al.. Upper gastrointestinal motor activity in patients with slowtransit constipation. Further evidence for an enteric neuropathy. Dig Dis Sci 1996;41:1999\u20132005.","journal-title":"Dig Dis Sci"},{"key":"BF02237134_CR3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/BF01540409","volume":"35","author":"M Camilleri","year":"1990","unstructured":"Camilleri M, Fealey RD. Idiopathic autonomic denervation in 8 patients presenting with functional gastrointestinal disease. A causal association? Dig Dis Sci 1990;35:609\u201316.","journal-title":"Dig Dis Sci"},{"key":"BF02237134_CR4","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/bjs.1800760735","volume":"76","author":"DD Kerrigan","year":"1989","unstructured":"Kerrigan DD, Lucas MG, Sun WM, Donelly TC, Read NW. Idiopathic constipation associated with impaired urethrovescical and sacral reflex function. Br J Surg 1989;76:748\u201351.","journal-title":"Br J Surg"},{"key":"BF02237134_CR5","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/BF01311732","volume":"28","author":"A Watier","year":"1983","unstructured":"Watier A, Devroede G, Duranceau A,et al. Constipation with colonic inertia. A manifestation of systemic disease? Dig Dis Sci 1983;28:1025\u201333.","journal-title":"Dig Dis Sci"},{"key":"BF02237134_CR6","first-page":"1009","volume":"145","author":"WJ Dodds","year":"1985","unstructured":"Dodds WJ, Groh WJ, Darweesh RM, Lawson TL, Kishk SM, Kern MK. Sonographic measurement of gallbladder volume. Am J Radiol 1985;145:1009\u201311.","journal-title":"Am J Radiol"},{"key":"BF02237134_CR7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0168-8278(05)80324-1","volume":"21","author":"P Portincasa","year":"1994","unstructured":"Portincasa P, Di Ciaula A, Baldassarre G,et al. Gallbladder motor function in gallstone patients: sonographic andin vitro studies on the role of gallbladder, smooth muscle function and gallbladder wall inflammation. J Hepatol 1994;21:430\u201340.","journal-title":"J Hepatol"},{"key":"BF02237134_CR8","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/0016-5085(85)90569-4","volume":"89","author":"L Bolondi","year":"1985","unstructured":"Bolondi L, Bortolotti MS, Calleti T, Gaiani S, Lab\u00f2 G. Measurement of gastric emtpying by real-time ultrasonography. Gastroenterology 1985;89:752\u20139.","journal-title":"Gastroenterology"},{"key":"BF02237134_CR9","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1365-2362.1995.tb01953.x","volume":"25","author":"P Portincasa","year":"1995","unstructured":"Portincasa P, Di Ciaula A, Palmieri V,et al. Effects of cholestyramine on gallbladder and gastric emptying in obese and lean subjects. Eur J Clin Invest 1995;25:746\u201353.","journal-title":"Eur J Clin Invest"},{"key":"BF02237134_CR10","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1136\/gut.38.6.816","volume":"38","author":"K Hveem","year":"1996","unstructured":"Hveem K, Jones KL, Chatterton BE, Horowitz M. Scintigraphic measurement of gastric emptying and ultrasonographic assessment of antral area: relation to appetite. Gut 1996;38:816\u201321.","journal-title":"Gut"},{"key":"BF02237134_CR11","first-page":"546","volume":"85","author":"JH Bond","year":"1975","unstructured":"Bond JH, Levitt MD. Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurement. J Lab Clin Med 1975;85:546\u201355.","journal-title":"J Lab Clin Med"},{"key":"BF02237134_CR12","first-page":"385","volume":"10","author":"S Chaussade","year":"1986","unstructured":"Chaussade S, Roche H, Khyari A, Couturier D, Guerre J. Mesure du temps de transit colique: description et validation d'une nouvelle technique. Gastroenterol Clin Biol 1986;10:385\u20139.","journal-title":"Gastroenterol Clin Biol"},{"key":"BF02237134_CR13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0016-5085(87)90837-7","volume":"92","author":"A Metcalf","year":"1987","unstructured":"Metcalf A, Phillips SF, Zinsmeister AR, MacCarty AL, Beart RW, Wolff BG. A simplified assessment of segmental colonic transit. Gastroenterology 1987;92:40\u20137.","journal-title":"Gastroenterology"},{"key":"BF02237134_CR14","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/bjs.1800721221","volume":"72","author":"NR Womack","year":"1985","unstructured":"Womack NR, Williams NS, Holmfield JH, Morrison JF, Simpkins KC. New method for the dynamic assessment of anorectal function in constipation. Br J Surg 1985;72:994\u20138.","journal-title":"Br J Surg"},{"key":"BF02237134_CR15","first-page":"303","volume":"1","author":"RE Ryder","year":"1988","unstructured":"Ryder RE, Marshall R, Johnson KJ, Ryder AP, Owens DR, Hayes TM: Acetylcholine sweat-spot test for autonomic denervation. Lancet 1988;1:303\u20135.","journal-title":"Lancet"},{"key":"BF02237134_CR16","first-page":"207","volume-title":"Neurogastroenterology","author":"DF Altomare","year":"1996","unstructured":"Altomare DF. Diagnostic tests of the autonomic nervous system. In: Corazziari E, ed. Neurogastroenterology. Berlin: Walter De Gruyter & Co., 1996: 207\u201320."},{"key":"BF02237134_CR17","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1136\/gut.33.11.1539","volume":"33","author":"DF Altomare","year":"1992","unstructured":"Altomare DF, Pilot M-A, Scott M,et al. Detection of subclinical autonomic neuropathy in constipated patients using a sweat test. Gut 1992;33:1539\u201343.","journal-title":"Gut"},{"key":"BF02237134_CR18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1540-8159.1993.tb01600.x","volume":"16","author":"FM Fouad","year":"1993","unstructured":"Fouad FM, Sitthisook S, Vaneiro G,et al. Sensitivity and specificity of the tilt table test n young patients with unexplained syncope. PACE Pacing Clin Electrophysiol 1993;16:394\u2013400.","journal-title":"PACE Pacing Clin Electrophysiol"},{"key":"BF02237134_CR19","first-page":"296","volume-title":"Statistical methods in medical research","author":"P Armitage","year":"1987","unstructured":"Armitage P, Berry G. Statistical methods in medical research. 2nd ed. London: Blackwell Scientific Pubns, Ltd., 1987:296.","edition":"2nd ed."},{"key":"BF02237134_CR20","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1007\/BF02049813","volume":"37","author":"JM Jorge","year":"1994","unstructured":"Jorge JM, Yang KY, Wexner SD. Incidence and clinical significance of sigmoidocele as determined by new classification. Dis Colon Rectum 1994;37:1112\u20137.","journal-title":"Dis Colon Rectum"},{"key":"BF02237134_CR21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1136\/gut.34.3.397","volume":"34","author":"AE Bharucha","year":"1993","unstructured":"Bharucha AE, Camilleri M, Low PA, Zinsmeister AR. Autonomic dysfunction in gastrointestinal motility disorders. Gut 1993;34:397\u2013401.","journal-title":"Gut"},{"key":"BF02237134_CR22","first-page":"645","volume":"76","author":"DJ Waldron","year":"1989","unstructured":"Waldron DJ, Williams NS, Kumar D, Hallan RI, Swash M. Is intractable constipation associated with a systemic autonomic neuropathy? [Abstract]. Br J Surg 1989;76:645.","journal-title":"Br J Surg"},{"key":"BF02237134_CR23","first-page":"1471","volume":"90","author":"E Surrenti","year":"1995","unstructured":"Surrenti E, Rath DM, Pemberton JH, Camilleri M. Audit of constipation in a tertiary referral gastroenterology practice. Am J Gastroenterol 1995;90:1471\u20135.","journal-title":"Am J Gastroenterol"},{"key":"BF02237134_CR24","first-page":"748","volume":"90","author":"JM Redmond","year":"1995","unstructured":"Redmond JM, Smith GW, Barofsky I, Ratych RE, Goldsborough DC, Schuster MM. Physiological tests to predict long-term outcome of total abdominal colectomy for intractable constipation. Am J Gastroenterol 1995;90:748\u201353.","journal-title":"Am J Gastroenterol"},{"key":"BF02237134_CR25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0140-6736(93)92479-D","volume":"341","author":"KW Heaton","year":"1993","unstructured":"Heaton KW, Emmett PM, Symes CL, Braddon FE. An explanation for gallstones on normal weight woman: slow intestinal transit. Lancet 1993;341:8\u201310.","journal-title":"Lancet"},{"key":"BF02237134_CR26","first-page":"65","volume-title":"Pathogenesis of cholesterol gallstones","author":"MFJ Stolk","year":"1993","unstructured":"Stolk MFJ, van Erpecum KJ, Samson M,et al. Interdigestive gallbladder emptying, antroduodenal motility and motilin release in cholesterol gallstone patients. In Stolk MF, ed. Pathogenesis of cholesterol gallstones. Utrecht: Thesis Universiteit Utrecht, 1993:65\u201378."},{"key":"BF02237134_CR27","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/0016-5085(95)90348-8","volume":"109","author":"RP Jazrawi","year":"1995","unstructured":"Jazrawi RP, Pazzi P, Petroni ML,et al. Postprandial gallbladder motor function: refilling and turnover of bile in health and cholelithiasis. Gastroenterology 1995;109:582\u201391.","journal-title":"Gastroenterology"},{"key":"BF02237134_CR28","unstructured":"Veysey MJ, Gathercole DJ, Mallet A, Murphy GM, Dowling RH. Prolonged large bowel transit is associated with an increase in input rate and pool size of deoxycholic acid. J Hepatol 1997;26:A170."},{"key":"BF02237134_CR29","first-page":"482","volume":"74","author":"JD Ostrow","year":"1969","unstructured":"Ostrow JD. Absorption by the gallbladder of bile salts, sulfobromophtalein and iodipamide. J Lab Clin Med 1969;74:482\u201394.","journal-title":"J Lab Clin Med"},{"key":"BF02237134_CR30","unstructured":"Vevsey MJ, Gathercole DJ, Mallet A, Murphy GM, Dowling RH. Prolonged large bowel transit is associated with an increase in the input rate and pool size of deoxycholic acid. J Hepatol 1997;26:A170."},{"key":"BF02237134_CR31","unstructured":"Hemingway DM, Murray WR, Finlay IG. Idiopathic slow transit constipation. Is there also an abnormality of gallbladder and gastric function? Gut 1994;35:S57"},{"key":"BF02237134_CR32","unstructured":"Kumar D, Waldron D, Williams NS, Wingate DL. Slow transit constipation: a pan-enteric motor disorder? Gastroenterology 1989;96:A277."},{"key":"BF02237134_CR33","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/bjs.1800811142","volume":"81","author":"B Panagamuwa","year":"1994","unstructured":"Panagamuwa B, Kumar D, Ortiz J, Keighley MR. Motor abnormalities in the terminal ileum of patients with chronic idiopathic constipation. Br J Surg 1994;81:1685\u20138.","journal-title":"Br J Surg"},{"key":"BF02237134_CR34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0016-5085(87)90136-3","volume":"92","author":"JC Reynolds","year":"1987","unstructured":"Reynolds JC, Ouyang A, Lee CA, Baker L, Sunshine AG, Cohen S. Chronic severe constipation. Prospective motility studies in 25 consecutive patients. Gastroenterology 1987;92:414\u201320.","journal-title":"Gastroenterology"},{"key":"BF02237134_CR35","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/0016-5085(94)90775-7","volume":"106","author":"M Camilleri","year":"1994","unstructured":"Camilleri M. Functional gastrointestinal disease and the autonomic nervous system: a way ahead? Gastroenterology 1994;106:1114\u20138.","journal-title":"Gastroenterology"},{"key":"BF02237134_CR36","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/BF02156270","volume":"33","author":"MA Kamm","year":"1990","unstructured":"Kamm MA, Lennard-Jones JE. Rectal mucosal electrosensory testing\u2014evidence for a rectal sensory neuropathy in idiopathic constipation. Dis Colon Rectum 1990;33:419\u201323.","journal-title":"Dis Colon Rectum"},{"key":"BF02237134_CR37","unstructured":"Raethjen I, Pilot MA, Anand P, Warner G, Williams NS. Selective autonomic deficits in slow transit constipation. Gut 1994;35:S28"},{"key":"BF02237134_CR38","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/0016-5085(95)90439-5","volume":"108","author":"P Iovino","year":"1995","unstructured":"Iovino P, Azpiroz F, Domingo E, Malagelada JE. The sympathetic nervous system modulates perception and reflex responses to gut distention in humans. Gastroenterology 1995;108:680\u20136.","journal-title":"Gastroenterology"}],"container-title":["Diseases of the Colon & Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1007\/BF02237134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T16:55:04Z","timestamp":1620924904000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003453-199942020-00017"}},"subtitle":["Solitary symptom of a systemic gastrointestinal disease"],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02237134","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[1999,2]]}}}