{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:54:33Z","timestamp":1785858873267,"version":"3.56.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1007\/bf02237425","type":"journal-article","created":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:20:04Z","timestamp":1129854004000},"page":"1222-1226","source":"Crossref","is-referenced-by-count":28,"title":["Colorectal cancer before the age of 40"],"prefix":"10.1097","volume":"43","author":[{"given":"Fran\u00e7ois","family":"Paraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Jothy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02237425_CR1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/bjs.1800770605","volume":"77","author":"G Enblad","year":"1990","unstructured":"Enblad G, Enblad P, Adami HO, Glimelius B, Krusemo U, P\u00e5hlman L. Relationship between age and survival in cancer of the colon and rectum with special reference to patients less than 40 years of age. Br J Surg 1990;77:611\u20136.","journal-title":"Br J Surg"},{"key":"BF02237425_CR2","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/0929-693X(96)81247-4","volume":"2","author":"S Chafai","year":"1995","unstructured":"Chafai S, Martelli H, Goulet O,et al. Ad\u00e9nocarcinome sur tumeur villeuse du rectum chez un adolescent. Arch Pediatr 1995;2:762\u20135.","journal-title":"Arch Pediatr"},{"key":"BF02237425_CR3","first-page":"105","volume":"183","author":"JC Cusack","year":"1996","unstructured":"Cusack JC, Giacco GG, Cleary K,et al. Survival factors in 186 patients younger than 40 years old with colorectal adenocarcinoma. J Am Coll Surg 1996;183:105\u201312.","journal-title":"J Am Coll Surg"},{"key":"BF02237425_CR4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/1097-0142(19880215)61:4<835::AID-CNCR2820610432>3.0.CO;2-X","volume":"61","author":"J Domergue","year":"1988","unstructured":"Domergue J, Ismail M, Astre C,et al. Colorectal carcinoma in patients younger than 40 years of age. Montpellier Cancer Institute experience with 78 patients. Cancer 1988;61:835\u201340.","journal-title":"Cancer"},{"key":"BF02237425_CR5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jso.2930510311","volume":"51","author":"K Marble","year":"1992","unstructured":"Marble K, Banerjee S, Greenwald L. Colorectal carcinoma in young patients. J Surg Oncol 1992;51:179\u201382.","journal-title":"J Surg Oncol"},{"key":"BF02237425_CR6","first-page":"78","volume":"61","author":"ED McGahren 3rd","year":"1995","unstructured":"McGahren ED, 3rd, Mills SE, Wilhelm MC. Colorectal carcinoma in patients 30 years of age and younger. Am Surg 1995;61:78\u201382.","journal-title":"Am Surg"},{"key":"BF02237425_CR7","first-page":"10","volume":"50","author":"PA Moore","year":"1984","unstructured":"Moore PA, Dilawari RA, Fidler WJ. Adenocarcinoma of the colon and rectum in patients less than 40 years of age. Am Surg 1984;50:10\u20134.","journal-title":"Am Surg"},{"key":"BF02237425_CR8","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/BF02554552","volume":"32","author":"C Smith","year":"1989","unstructured":"Smith C, Butler JA. Colorectal cancer in patients younger than 40 years of age. Dis Colon Rectum 1989;32:843\u20136.","journal-title":"Dis Colon Rectum"},{"key":"BF02237425_CR9","first-page":"150","volume":"31","author":"MC Taylor","year":"1988","unstructured":"Taylor MC, Pounder D, Ali-Ridha NH, Bodurtha A, MacMullin EC. Prognostic factors in colorectal carcinoma of young adults. Can J Surg 1988;31:150\u20133.","journal-title":"Can J Surg"},{"key":"BF02237425_CR10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00000478-197910000-00006","volume":"3","author":"SE Mills","year":"1979","unstructured":"Mills SE, Allen MS Jr. Colorectal carcinoma in the first three decades of life. Am J Surg Pathol 1979;3:443\u20138.","journal-title":"Am J Surg Pathol"},{"key":"BF02237425_CR11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/BF02050596","volume":"34","author":"ML Palmer","year":"1991","unstructured":"Palmer ML, Herrera L, Petrelli NJ. Colorectal adenocarcinoma in patients less than 40 years of age. Dis Colon Rectum 1991;34:343\u20136.","journal-title":"Dis Colon Rectum"},{"key":"BF02237425_CR12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/BF02554121","volume":"29","author":"M Adloff","year":"1986","unstructured":"Adloff M, Arnaud JP, Schloegel M, Thibaud D, Bergamaschi R. Colorectal cancer in patients under 40 years of age. Dis Colon Rectum 1986;29:322\u20135.","journal-title":"Dis Colon Rectum"},{"key":"BF02237425_CR13","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/1097-0142(19841001)54:7<1478::AID-CNCR2820540744>3.0.CO;2-A","volume":"54","author":"EN Beckman","year":"1984","unstructured":"Beckman EN, Gathright JB, Ray JE. A potentially brighter prognosis for colon carcinoma in the third and fourth decades. Cancer 1984;54:1478\u201381.","journal-title":"Cancer"},{"key":"BF02237425_CR14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF02586840","volume":"23","author":"S B\u00fclow","year":"1980","unstructured":"B\u00fclow S. Colorectal cancer in patients less than 40 years of age in Denmark, 1943\u20131967. Dis Colon Rectum 1980;23:327\u201336.","journal-title":"Dis Colon Rectum"},{"key":"BF02237425_CR15","first-page":"624","volume":"12","author":"B Courtois","year":"1988","unstructured":"Courtois B, Hillon P, Boutron MC,et al. Les cancers rectocoliques du sujet jeune. Etude de population (C\u00f4te-d'Or: 1976\u20131983). Gastroenterol Clin Biol 1988;12:624\u20138.","journal-title":"Gastroenterol Clin Biol"},{"key":"BF02237425_CR16","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0002-9610(05)80695-6","volume":"166","author":"DT Cozart","year":"1993","unstructured":"Cozart DT, Lang NP, Hauer-Jensen M, Contributors to the Southwestern Surgical Congress Unusual Case Registry. Colorectal cancer in patients under 30 years of age. Am J Surg 1993;166:764\u20137.","journal-title":"Am J Surg"},{"key":"BF02237425_CR17","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/bjs.1800810519","volume":"81","author":"SD Heys","year":"1994","unstructured":"Heys SD, Sherif A, Bagley JS, Brittenden J, Smart C, Eremin O. Prognostic factors and survival of patients aged less than 45 years with colorectal cancer. Br J Surg 1994;81:685\u20138.","journal-title":"Br J Surg"},{"key":"BF02237425_CR18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF02156258","volume":"33","author":"WH Isbister","year":"1990","unstructured":"Isbister WH, Fraser J. Large-bowel cancer in the young: a national survival study. Dis Colon Rectum 1990;33:363\u20136.","journal-title":"Dis Colon Rectum"},{"key":"BF02237425_CR19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1080\/00365521.1984.12005784","volume":"19","author":"HJ J\u00e4rvinen","year":"1984","unstructured":"J\u00e4rvinen HJ, Turunen MJ. Colorectal carcinoma before 40 years of age: prognosis and predisposing conditions. Scand J Gastroenterol 1984;19:634\u20138.","journal-title":"Scand J Gastroenterol"},{"key":"BF02237425_CR20","first-page":"607","volume":"60","author":"PY Lee","year":"1994","unstructured":"Lee PY, Fletcher WS, Sullivan ES, Vetto JT. Colorectal cancer in young patients: characteristics and outcome. Am Surg 1994;60:607\u201312.","journal-title":"Am Surg"},{"key":"BF02237425_CR21","first-page":"1","volume":"172","author":"DC MacGillivray","year":"1991","unstructured":"MacGillivray DC, Swartz SE, Robinson AM, Cruess DF, Smith LE. Adenocarcinoma of the colon and rectum in patients less than 40 years of age. Surg Gynecol Obstet 1991;172:1\u20137.","journal-title":"Surg Gynecol Obstet"},{"key":"BF02237425_CR22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF02553102","volume":"25","author":"U \u00d6hman","year":"1982","unstructured":"\u00d6hman U. Colorectal carcinoma in patients less than 40 years of age. Dis Colon Rectum 1982;25:209\u201314.","journal-title":"Dis Colon Rectum"},{"key":"BF02237425_CR23","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-83693-0","volume-title":"Histological typing of intestinal tumors. WHO international histological classification of tumors","author":"JR Jass","year":"1989","unstructured":"Jass JR, Sobin LH. Histological typing of intestinal tumors. WHO international histological classification of tumors. Berlin: Springer-Verlag, 1989."},{"key":"BF02237425_CR24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2559.1986.tb02497.x","volume":"10","author":"JR Jass","year":"1986","unstructured":"Jass JR, Atkin WS, Cuzick J,et al. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology 1986;10:437\u201359.","journal-title":"Histopathology"},{"key":"BF02237425_CR25","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/BF02238588","volume":"36","author":"K Hase","year":"1993","unstructured":"Hase K, Shatney C, Johnson D, Trollope M, Vierra M. Prognostic value of tumor \u201cbudding\u201d in patients with colorectal cancer. Dis Colon Rectum 1993;36:627\u201335.","journal-title":"Dis Colon Rectum"},{"key":"BF02237425_CR26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/path.1700350303","volume":"35","author":"CE Dukes","year":"1932","unstructured":"Dukes CE. The classification of cancer of the rectum. J Pathol Bacteriol 1932;35:323\u201332.","journal-title":"J Pathol Bacteriol"},{"key":"BF02237425_CR27","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1002\/1097-0142(19930315)71:6<1954::AID-CNCR2820710605>3.0.CO;2-#","volume":"71","author":"IF al-Sheneber","year":"1993","unstructured":"al-Sheneber IF, Shibata HR, Sampalis J, Jothy S. Prognostic significance of proliferating cell nuclear antigen expression in colorectal cancer. Cancer 1993;71:1954\u20139.","journal-title":"Cancer"},{"key":"BF02237425_CR28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"EL Kaplan","year":"1958","unstructured":"Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457\u201381.","journal-title":"J Am Stat Assoc"},{"key":"BF02237425_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","volume":"35","author":"R Peto","year":"1977","unstructured":"Peto R, Pike MC, Armitage P,et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 1977;35:1\u201339.","journal-title":"Br J Cancer"},{"key":"BF02237425_CR30","first-page":"1067","volume":"54","author":"RC Green","year":"1994","unstructured":"Green RC, Narod SA, Morasse J,et al. Hereditary non-polyposis colon cancer: analysis of linkage to 2p15-16 places the COCA1 locus telomeric to D2S123 and reveals genetic heterogeneity in seven Canadian families. Am J Hum Genet 1994;54:1067\u201377.","journal-title":"Am J Hum Genet"},{"key":"BF02237425_CR31","first-page":"205","volume":"10","author":"DJ Galloway","year":"1984","unstructured":"Galloway DJ, Burns HJ, Bear H, Jarrett F, Boyle P, Georges WD. Colorectal carcinoma in young adults. Clin Oncol 1984;10:205\u201311.","journal-title":"Clin Oncol"},{"key":"BF02237425_CR32","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0016-5085(91)90279-T","volume":"100","author":"PM Griffin","year":"1991","unstructured":"Griffin PM, Liff JM, Greenberg RS, Clark WS. Adenocarcinomas of the colon and rectum in persons under 40 years old. A population-based study. Gastroenterology 1991;100:1033\u201340.","journal-title":"Gastroenterology"},{"key":"BF02237425_CR33","first-page":"367","volume":"18","author":"HS Cooper","year":"1991","unstructured":"Cooper HS, Slemmer JR. Surgical pathology of carcinoma of the colon and rectum. Semin Oncol 1991;18:367\u201380.","journal-title":"Semin Oncol"},{"key":"BF02237425_CR34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF02055674","volume":"40","author":"EL Bokey","year":"1997","unstructured":"Bokey EL, Chapuis PH, Dent OF,et al. Factors affecting survival after excision of the rectum for cancer: a multivariate analysis. Dis Colon Rectum 1997;40:3\u201310.","journal-title":"Dis Colon Rectum"},{"key":"BF02237425_CR35","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/BF02051074","volume":"34","author":"A Horn","year":"1991","unstructured":"Horn A, Dahl O, Morild I. Venous and neural invasion as predictors of reccurrence in rectal adenocarcinoma. Dis Colon Rectum 1991;34:798\u2013804.","journal-title":"Dis Colon Rectum"},{"key":"BF02237425_CR36","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/1097-0142(19880301)61:5<1018::AID-CNCR2820610527>3.0.CO;2-H","volume":"61","author":"MJ Krasna","year":"1988","unstructured":"Krasna MJ, Flancbaum L, Cody RP, Shneibaum S, Ben Ari G. Vascular and neural invasion in colorectal carcinoma. Incidence and prognostic significance. Cancer 1988;61:1018\u201323.","journal-title":"Cancer"},{"key":"BF02237425_CR37","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/0959-8049(95)00077-1","volume":"31A","author":"C Bognel","year":"1995","unstructured":"Bognel C, Rekacewicz C, Mankarios H,et al. Prognostic value of neural invasion in rectal carcinoma: a multivariate analysis on 339 patients with curative resection. Eur J Cancer 1995;31A:894\u20138.","journal-title":"Eur J Cancer"},{"key":"BF02237425_CR38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1096-9098(199809)69:1<28::AID-JSO6>3.0.CO;2-M","volume":"69","author":"S Nakae","year":"1998","unstructured":"Nakae S, Nakamura T, Ikegawa R, Yoshioka H, Shirono J, Tabuchi Y. Evaluation of argyrophilic nucleolar organizer region and proliferating cell nuclear antigen in colorectal cancer. J Surg Oncol 1998;69:28\u201335.","journal-title":"J Surg Oncol"},{"key":"BF02237425_CR39","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/BF02053699","volume":"34","author":"HF Vasen","year":"1991","unstructured":"Vasen HF, Mecklin JP, Meera Khan P, Lynch HT. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Retum 1991;34:424\u20135.","journal-title":"Dis Colon Retum"},{"key":"BF02237425_CR40","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nm0495-348","volume":"1","author":"B Liu","year":"1995","unstructured":"Liu B, Farrington SM, Petersen GM,et al. Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med 1995;1:348\u201352.","journal-title":"Nat Med"},{"key":"BF02237425_CR41","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-2559.1998.00442.x","volume":"32","author":"JR Jass","year":"1998","unstructured":"Jass JR. Diagnosis of hereditary non-polyposis colorectal cancer. Histopathology 1998;32:491\u20137.","journal-title":"Histopathology"}],"container-title":["Diseases of the Colon &amp; Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00002030-200601090-00029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:00:33Z","timestamp":1785855633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-200043090-00007"}},"subtitle":["A case-control study"],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02237425","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}