{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:55:26Z","timestamp":1785858926283,"version":"3.56.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1007\/bf02238021","type":"journal-article","created":{"date-parts":[[2005,11,14]],"date-time":"2005-11-14T12:03:30Z","timestamp":1131969810000},"page":"821-828","source":"Crossref","is-referenced-by-count":7,"title":["Nitric oxide production is diminished in colonic circular muscle from acquired megacolon"],"prefix":"10.1097","volume":"43","author":[{"given":"Timothy R.","family":"Koch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"Otterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon L.","family":"Telford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02238021_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0143-4179(95)90050-0","volume":"29","author":"E Gaumnitz","year":"1995","unstructured":"Gaumnitz E, Sweet MA, Sengupta A, Singaram C. Nitrinergic and peptidergic innervations and their interrelationships in human colon. Neuropeptides 1995;29:1\u20139.","journal-title":"Neuropeptides"},{"key":"BF02238021_CR2","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","volume":"329","author":"S Moncada","year":"1993","unstructured":"Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002\u201312.","journal-title":"N Engl J Med"},{"key":"BF02238021_CR3","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1073\/pnas.86.13.5159","volume":"86","author":"RG Knowles","year":"1989","unstructured":"Knowles RG, Palacios M, Palmer RM, Moncada S. Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci U S A 1989;86:5159\u201362.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BF02238021_CR4","doi-asserted-by":"crossref","first-page":"14519","DOI":"10.1016\/S0021-9258(18)42066-2","volume":"267","author":"SP Janssens","year":"1992","unstructured":"Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD. Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor\/nitric oxide synthase. J Biol Chem 1992;267:14519\u201322.","journal-title":"J Biol Chem"},{"key":"BF02238021_CR5","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/351714a0","volume":"351","author":"DS Bredt","year":"1991","unstructured":"Bredt DS, Hwang PH, Glatt C, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 1991;351:714\u20138.","journal-title":"Nature"},{"key":"BF02238021_CR6","doi-asserted-by":"crossref","first-page":"21644","DOI":"10.1016\/S0021-9258(17)31854-9","volume":"269","author":"JM Griscavage","year":"1994","unstructured":"Griscavage JM, Fukuto JM, Komori Y, Ignarro LJ. Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. J Biol Chem 1994;269:21644\u20139.","journal-title":"J Biol Chem"},{"key":"BF02238021_CR7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0304-3940(94)91025-1","volume":"167","author":"AM Yunker","year":"1994","unstructured":"Yunker AM, Galligan JJ. Extrinsic denervation increases NADPH diaphorase staining in myenteric nerves of guinea pig ileum. Neurosci Lett 1994;167:51\u20134.","journal-title":"Neurosci Lett"},{"key":"BF02238021_CR8","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/0016-5085(93)91003-Z","volume":"104","author":"GE Boeckxstaens","year":"1993","unstructured":"Boeckxstaens GE, Pelckmans PA, Herman AG, Van Maercke YM. Involvement of nitric oxide in the inhibitory innervation of the human isolated colon. Gastroenterology 1993;104:690\u20137.","journal-title":"Gastroenterology"},{"key":"BF02238021_CR9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0016-5085(92)90120-N","volume":"102","author":"DE Burleigh","year":"1992","unstructured":"Burleigh DE. N-Nitro-L-arginine reduces nonadrenergic, noncholinergic relaxations of human gut. Gastroenterology 1992;102:679\u201383.","journal-title":"Gastroenterology"},{"key":"BF02238021_CR10","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0016-5085(93)90943-7","volume":"105","author":"KD Keef","year":"1993","unstructured":"Keef KD, Du C, Ward SM, McGregor B, Sanders KM. Enteric inhibitory neural regulation of human colonic circular muscle: role of nitric oxide. Gastroenterology 1993;105:1009\u201316.","journal-title":"Gastroenterology"},{"key":"BF02238021_CR11","first-page":"414","volume":"12","author":"JL Kantor","year":"1924","unstructured":"Kantor JL. A clinical study of some common anatomical abnormalities of the colon. I. The redundant colon. Am J Roentgenol 1924;12:414\u201330.","journal-title":"Am J Roentgenol"},{"key":"BF02238021_CR12","first-page":"543","volume":"52","author":"JA Carney","year":"1977","unstructured":"Carney JA, Hayles AB. Alimentary tract manifestations of multiple endocrine neoplasia, type 2b. Mayo Clin Proc 1977;52:543\u20138.","journal-title":"Mayo Clin Proc"},{"key":"BF02238021_CR13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF01300699","volume":"31","author":"JF Macedo","year":"1986","unstructured":"Macedo JF, Meneghelli UG, Oliveira RB, Godoy RA, Troncon LE, Dantas RO. Effect of CCK-OP and intraduodenal administration of essential amino acids on intraluminal pressures of sigmoid and rectum in patients with Chagasic megacolon. Dig Dis Sci 1986;31:145\u201350.","journal-title":"Dig Dis Sci"},{"key":"BF02238021_CR14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0016-5085(88)80034-9","volume":"95","author":"MM Yoshida","year":"1988","unstructured":"Yoshida MM, Krishnamurthy S, Wattchow DA, Furness JB, Schuffler MD. Megacolon in myotonic dystrophy caused by a degenerative neuropathy of the myenteric plexus. Gastroenterology 1988;95:820\u20137.","journal-title":"Gastroenterology"},{"key":"BF02238021_CR15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0167-0115(93)90159-6","volume":"48","author":"TR Koch","year":"1993","unstructured":"Koch TR, Schulte-Bockholt A, Telford GL, Otterson MF, Murad TM, Stryker SJ. Acquired megacolon is associated with alteration of vasoactive intestinal peptide levels and acetylcholinesterase activity. Regulatory Peptides 1993;48:309\u201319.","journal-title":"Regulatory Peptides"},{"key":"BF02238021_CR16","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/BF02088566","volume":"41","author":"TR Koch","year":"1996","unstructured":"Koch TR, Schulte-Bockholt A, Otterson MF,et al. Decreased vasoactive intestinal peptide levels and glutathione depletion in acquired megacolon. Dig Dis Sci 1996;41:1409\u201316.","journal-title":"Dig Dis Sci"},{"key":"BF02238021_CR17","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1073\/pnas.88.17.7797","volume":"88","author":"TM Dawson","year":"1991","unstructured":"Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Snyder SH. Nitric oxide synthase and neuronal NADPH-d are identical in brain and peripheral tissue. Proc Natl Acad Sci USA 1991;88:7797\u2013801.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF02238021_CR18","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1007\/BF02063253","volume":"40","author":"C Cortesini","year":"1995","unstructured":"Cortesini C, Cianchi F, Infantino A, Lise M. Nitric oxide synthase and VIP distribution in enteric nervous system in idiopathic chronic constipation. Dig Dis Sci 1995;40:2450\u20135.","journal-title":"Dig Dis Sci"},{"key":"BF02238021_CR19","first-page":"233","volume":"25","author":"N Aoki","year":"1989","unstructured":"Aoki N,et al. Peristaltic reflex and peptidergic nerve control in megacolon. Nippon Heikatsukin Gakkai Zasshi 1989;25:233\u20135.","journal-title":"Nippon Heikatsukin Gakkai Zasshi"},{"key":"BF02238021_CR20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF01893094","volume":"10","author":"DM Preston","year":"1985","unstructured":"Preston DM, Lennard-Jones JE, Thomas BM. Towards a radiologic definition of idiopathic megacolon. Gastrointest Radiol 1985;10:167\u20139.","journal-title":"Gastrointest Radiol"},{"key":"BF02238021_CR21","first-page":"403","volume":"176","author":"JA Heine","year":"1993","unstructured":"Heine JA, Wong WD, Goldberg SM. Collective review: Surgical treatment for constipation. Surg Gynecol Obstet 1993;176:403\u201310.","journal-title":"Surg Gynecol Obstet"},{"key":"BF02238021_CR22","first-page":"779","volume":"54","author":"RA McCready","year":"1979","unstructured":"McCready RA, Beart RW Jr. The surgical treatment of incapacitating constipation associated with idiopathic megacolon. Mayo Clinic Proc 1979;54:779\u201383.","journal-title":"Mayo Clinic Proc"},{"key":"BF02238021_CR23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0016-5085(88)90293-4","volume":"95","author":"TR Koch","year":"1988","unstructured":"Koch TR, Carney JA, Go VL, Szurszewski JH. Spontaneous contractions and some electrophysiologic properties of circular muscle from normal sigmoid colon and ulcerative colitis. Gastroenterology 1988;95:77\u201384.","journal-title":"Gastroenterology"},{"key":"BF02238021_CR24","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/0016-5085(90)91073-F","volume":"98","author":"TR Koch","year":"1990","unstructured":"Koch TR, Carney JA, Go VL, Szurszewski JH. Altered inhibitory innervation of circular smooth muscle in Crohn's colitis: Association with decreased vasoactive intestinal polypeptide levels. Gastroenterology 1990;98:1437\u201344.","journal-title":"Gastroenterology"},{"key":"BF02238021_CR25","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1007\/BF02140901","volume":"40","author":"JF Stebbing","year":"1997","unstructured":"Stebbing JF, Brading AF, Mortensen NJ. Role of nitric oxide in relaxation of the longitudinal layer of rectal smooth muscle. Dis Colon Rectum 1997;40:706\u201310.","journal-title":"Dis Colon Rectum"},{"key":"BF02238021_CR26","first-page":"151","volume":"40","author":"JB Furness","year":"1992","unstructured":"Furness JB, Pombolo S, Young HM,et al. Structure and function of chemically specified enteric neurons in the guinea pig intestine [abstract]. Regul Pept 1992;40:151.","journal-title":"Regul Pept"},{"key":"BF02238021_CR27","first-page":"G334","volume":"264","author":"JR Grider","year":"1993","unstructured":"Grider JR. Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis. Am J Physiol 1993;264:G334\u201340.","journal-title":"Am J Physiol"},{"key":"BF02238021_CR28","first-page":"G660","volume":"265","author":"KS Murthy","year":"1993","unstructured":"Murthy KS, Zhang KM, Jin JG, Grider JR, Makhlouf GM. VIP-mediated G protein-coupled Ca2+ influx activates a constitutive NOS in dispersed gastric muscle cells. Am J Physiol 1993;265(4 Part 1):G660\u201371.","journal-title":"Am J Physiol"},{"key":"BF02238021_CR29","first-page":"26","volume":"71","author":"PL Feldman","year":"1993","unstructured":"Feldman PL, Griffith OW, Stuehr DJ. The surprising life of nitric oxide. Chem Eng News 1993;71:26\u201338.","journal-title":"Chem Eng News"},{"key":"BF02238021_CR30","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/BF01311226","volume":"36","author":"TR Koch","year":"1991","unstructured":"Koch TR, Carney JA, Go VL, Szurszewski JH. Inhibitory neuropeptides and intrinsic inhibitory innervation of descending human colon. Dig Dis Sci 1991;36:712\u20138.","journal-title":"Dig Dis Sci"},{"key":"BF02238021_CR31","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0306-3623(95)00088-7","volume":"27","author":"E Sotirov","year":"1996","unstructured":"Sotirov E, Dobreva G, Noeva A, Papasova M. Nitric oxide modulates cholinergic neurotransmission in cat duodenum. Gen Pharmacol 1996;27:395\u20138.","journal-title":"Gen Pharmacol"},{"key":"BF02238021_CR32","first-page":"378","volume":"282","author":"S Chakder","year":"1997","unstructured":"Chakder S, Rattan S. L-arginine deficiency causes suppression of nonadrenergic noncholinergic nerve-mediated smooth muscle relaxation: Role of L-citrulline recycling. J Pharm Exp Ther 1997;282:378\u201384.","journal-title":"J Pharm Exp Ther"},{"key":"BF02238021_CR33","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/sj.bjp.0700949","volume":"120","author":"CW Shuttleworth","year":"1997","unstructured":"Shuttleworth CW, Conlon SB, Sanders KM. Regulation of citrulline recycling in nitric oxide-dependent neurotransmission in the murine proximal colon. Br J Pharmacol 1997;120:707\u201313.","journal-title":"Br J Pharmacol"},{"key":"BF02238021_CR34","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/0306-4522(95)00193-M","volume":"68","author":"CW Shuttleworth","year":"1995","unstructured":"Shuttleworth CW, Burns AJ, Ward SM, O'Brien WE, Sanders KM. Recycling of L- citrulline to sustain nitric oxide-dependent enteric neurotransmission. Neuroscience 1995;68:1295\u2013304.","journal-title":"Neuroscience"},{"key":"BF02238021_CR35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1113\/jphysiol.1987.sp016607","volume":"388","author":"M Bouvier","year":"1987","unstructured":"Bouvier M, Grimaud JC, Naudy B, Salducci J. Effects of morphine on electrical activity of the rectum in man. J Physiol (London) 1987;388:153\u201361.","journal-title":"J Physiol (London)"},{"key":"BF02238021_CR36","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/0016-5085(88)90673-7","volume":"94","author":"PN Kaufman","year":"1988","unstructured":"Kaufman PN, Krevsky B, Malmud LS,et al. Role of opiate receptors in the regulation of colonic transit. Gastroenterology 1988;94:1351\u20136.","journal-title":"Gastroenterology"},{"key":"BF02238021_CR37","first-page":"102","volume-title":"Bockus gastroenterology","author":"HV Ammon","year":"1994","unstructured":"Ammon HV, Koch TR. Diarrhea, Constipation, Part II. Constipation. In: Haubrich WS, Schaffner F, Berk JE, eds. Bockus gastroenterology. 5th ed. Philadelphia: WB Saunders, 1994;102\u201312.","edition":"5th ed."}],"container-title":["Diseases of the Colon & Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1007\/BF02238021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:00:15Z","timestamp":1785855615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-200043060-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02238021","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}