{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:58:13Z","timestamp":1785859093374,"version":"3.56.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3]]},"DOI":"10.1007\/bf02258308","type":"journal-article","created":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T14:03:40Z","timestamp":1132668220000},"page":"396-401","source":"Crossref","is-referenced-by-count":15,"title":["Immunohistochemical localization of cathepsin D in colorectal tumors"],"prefix":"10.1097","volume":"43","author":[{"given":"Jun","family":"Arao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fujimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BF02258308_CR1","first-page":"191","volume":"907","author":"K Tryggvason","year":"1987","unstructured":"Tryggvason K, H\u00f6yhty\u00e4 M, Salo T. Proteolytic degradation of extracellular matrix in tumor invasion. Biochim Biophys Acta 1987;907:191\u2013217.","journal-title":"Biochim Biophys Acta"},{"key":"BF02258308_CR2","first-page":"3688","volume":"48","author":"P Briozzo","year":"1988","unstructured":"Briozzo P, Morisset M, Capony F, Rougeot C, Rochefort H.In vitro degradation of extracellular matrix withMr 52,000 cathepsin D secreted by breast cancer cells. Cancer Res 1988;48:3688\u201392.","journal-title":"Cancer Res"},{"key":"BF02258308_CR3","first-page":"6045","volume":"50","author":"P Montcourrier","year":"1990","unstructured":"Montcourrier P, Mangat PH, Salazar G, Morisset M, Sahuquet A, Rochefort H. Cathepsin D in breast cancer cells can digest extracellular matrix in large vesicles. Cancer Res 1990;50:6045\u201354.","journal-title":"Cancer Res"},{"key":"BF02258308_CR4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/284067a0","volume":"284","author":"LA Liotta","year":"1980","unstructured":"Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM, Shafie S. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 1980;284:67\u20138.","journal-title":"Nature"},{"key":"BF02258308_CR5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0092-8674(80)90621-2","volume":"20","author":"B Westley","year":"1980","unstructured":"Westley B, Rochefort H. A secreted glycoprotein induced by estrogen in human breast cancer cell lines. Cell 1980;20:353\u201362.","journal-title":"Cell"},{"key":"BF02258308_CR6","first-page":"6008","volume":"49","author":"SM Thorpe","year":"1989","unstructured":"Thorpe SM, Rochefort H, Garcia M,et al. Association between high concentrations ofMr 52,000 cathepsin D and poor prognosis in primary human breast cancer. Cancer Res 1989;49:6008\u201314.","journal-title":"Cancer Res"},{"key":"BF02258308_CR7","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0140-6736(89)91487-6","volume":"2","author":"F Spyratos","year":"1989","unstructured":"Spyratos F, Maudelonde T, Brouillet JP,et al. Cathepsin D: an independent prognostic factor for metastasis of breast cancer. Lancet 1989;2:1115\u20138.","journal-title":"Lancet"},{"key":"BF02258308_CR8","first-page":"5198","volume":"52","author":"TE Kute","year":"1992","unstructured":"Kute TE, Shao ZM, Sugg NK, Long RT, Russell GB, Case LD. Cathepsin D as a prognostic indicator for nodenegative breast cancer patients using both immunoassay and enzymatic assays. Cancer Res 1992;52:5198\u2013203.","journal-title":"Cancer Res"},{"key":"BF02258308_CR9","first-page":"873","volume":"53","author":"MD Johnson","year":"1993","unstructured":"Johnson MD, Torri JA, Lippman ME, Dickson RB. The role of cathepsin D in the invasiveness of human breast cancer cells. Cancer Res 1993;53:873\u20137.","journal-title":"Cancer Res"},{"key":"BF02258308_CR10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0046-8177(94)90003-5","volume":"25","author":"T Castiglioni","year":"1994","unstructured":"Castiglioni T, Merino MJ, Elsner B, Lah TT, Sloane BF, Emmert-Buck MR. Immunohistochemical analysis of cathepsin D, B and in human breast cancer. Hum Pathol 1994;25:857\u201362.","journal-title":"Hum Pathol"},{"key":"BF02258308_CR11","first-page":"3809","volume":"49","author":"K Sheahan","year":"1989","unstructured":"Sheahan K, Shuja S, Murnane MJ. Cystein protease activities and tumor development in human colorectal carcinoma. Cancer Res 1989;49:3809\u201314.","journal-title":"Cancer Res"},{"key":"BF02258308_CR12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000227464","volume":"52","author":"FM Tumminello","year":"1995","unstructured":"Tumminello FM, Gebbia N, Pizzolanti G, Russo A, Bazan V, Leto G. Cathepsin D content in colorectal cancer. Oncology 1995;52:237\u201342.","journal-title":"Oncology"},{"key":"BF02258308_CR13","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0046-8177(96)90373-1","volume":"27","author":"K Matsuo","year":"1996","unstructured":"Matsuo K, Kobayashi I, Tsukuba T,et al. Immunohistochemical localization of cathepsin D and E in human gastric cancer: a possible correlation with local invasive and metastatic activities of carcinoma cells. Hum Pathol 1996;27:184\u201390.","journal-title":"Hum Pathol"},{"key":"BF02258308_CR14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/(SICI)1097-0215(19961115)68:4<479::AID-IJC13>3.0.CO;2-0","volume":"68","author":"SH Reig","year":"1996","unstructured":"Reig SH, Kim I, Janin A,et al. Regulation of cathepsin D dependent on the phenotype of colon carcinoma cells. Int J Cancer 1996;68:479\u201384.","journal-title":"Int J Cancer"},{"key":"BF02258308_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.97.1.1","volume":"97","author":"V Gieselman","year":"1983","unstructured":"Gieselman V, Pohlmann R, Hasilik A, Von Figura K. Biosynthesis and transport of cathepsin D in cultured human fibroblast. J Cell Biol 1983;97:1\u20135.","journal-title":"J Cell Biol"},{"key":"BF02258308_CR16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1432-1033.1981.tb06440.x","volume":"121","author":"A Hasilik","year":"1981","unstructured":"Hasilik A, Von Figura K. Oligosaccharides in lysosomal enzymes: distribution of high-mannose and complex oligosaccharides in cathepsin D and \u03b2-hexosaminidase. Eur J Biochem 1981;121:125\u20139.","journal-title":"Eur J Biochem"},{"key":"BF02258308_CR17","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.2672330","volume":"245","author":"E Rodriguez-Boulan","year":"1989","unstructured":"Rodriguez-Boulan E, Nelson WJ. Morphogenesis of the polarized epithelial cell phenotype. Science 1989;245:718\u201324.","journal-title":"Science"},{"key":"BF02258308_CR18","first-page":"77","volume":"16","author":"AM Valentini","year":"1996","unstructured":"Valentini AM, Pirrelli M, Armentano R, Caruso ML. The immunohistochemical expression of cathepsin D in colorectal cancer. Anticancer Res 1996;16:77\u201380.","journal-title":"Anticancer Res"},{"key":"BF02258308_CR19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/07357909709115762","volume":"15","author":"A Mayer","year":"1997","unstructured":"Mayer A, Fritz E, Fortelny R, Kofler K, Ludwig H. Immunohistochemical evaluation of cathepsin D expression in colorectal cancer. Cancer Invest 1997;15:106\u201310.","journal-title":"Cancer Invest"}],"container-title":["Diseases of the Colon &amp; Rectum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00003453-200043030-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:05:36Z","timestamp":1785855936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003453-200043030-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1007\/bf02258308","relation":{},"ISSN":["0012-3706"],"issn-type":[{"value":"0012-3706","type":"print"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}