{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:54:07Z","timestamp":1757703247358},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digest Dis Sci"],"published-print":{"date-parts":[[1996,3]]},"DOI":"10.1007\/bf02282324","type":"journal-article","created":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T14:00:24Z","timestamp":1138197624000},"page":"492-497","source":"Crossref","is-referenced-by-count":3,"title":["High systemic HCO 3 \u2212 and topical 16,16-dimethyl-PGE2 protect gastric mucosa against luminal acid by enhancing its preepithelial buffer capacity"],"prefix":"10.1007","volume":"41","author":[{"given":"T.","family":"Ranta-Knuuttila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mustonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kivilaakso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"issue":"suppl 87","key":"BF02282324_CR1","first-page":"25","volume":"18","author":"A Garner","year":"1989","unstructured":"Garner A, Flemstr\u00f6m G, Allen A: Gastroduodenal alkaline and mucus secretions. Scand J Gastroenterol 18(suppl 87):25\u201341, 1989","journal-title":"Scand J Gastroenterol"},{"key":"BF02282324_CR2","first-page":"1011","volume-title":"Physiology of the Gastrointestinal Tract","author":"G Flemstr\u00f6m","year":"1987","unstructured":"Flemstr\u00f6m G: Gastric and duodenal mucosal bicarbonate secretion.In Physiology of the Gastrointestinal Tract. LR Johnson, J Christensen, MJ Jackson, ED Jacobson, JH Walsh (eds). New York, Raven Press, 1987, pp 1011\u20131029"},{"key":"BF02282324_CR3","first-page":"G687","volume":"248","author":"SJ Konturek","year":"1985","unstructured":"Konturek SJ, Bilski J, Tasler J, Laskiewicz J: Gut hormones in stimulation of gastroduodenal alkaline secretion in conscious dogs. Am J Physiol 248(Gastrointest Liver Physiol 11):G687-G691, 1985","journal-title":"Am J Physiol"},{"key":"BF02282324_CR4","first-page":"759","volume-title":"Handbook of Physiology. Alimentary Canal. Secretion","author":"HW Davenport","year":"1967","unstructured":"Davenport HW: Physiological structure of the gastric mucosa.In Handbook of Physiology. Alimentary Canal. Secretion. C Code (ed). Washington, DC, American Physiology Society, 1967, pp 759\u2013779"},{"key":"BF02282324_CR5","first-page":"617","volume-title":"Physiology of the Gastrointestinal Tract","author":"A Allen","year":"1981","unstructured":"Allen A: Structure and function of gastrointestinal mucus.In Physiology of the Gastrointestinal Tract. LR Johnson, J Christensen, MJ Jackson, ED Jacobson, JH Walsh (ed). New York, Raven Press, 1981, pp 617\u2013639"},{"key":"BF02282324_CR6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1152\/physrev.1993.73.4.823","volume":"73","author":"A Allen","year":"1993","unstructured":"Allen A, Flemstr\u00f6m G, Garner A, Kivilaakso E: Gastroduodenal mucosal protection. Physiol Rev 73:823\u2013857, 1993","journal-title":"Physiol Rev"},{"key":"BF02282324_CR7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0016-5085(81)90496-0","volume":"81","author":"IN Ross","year":"1981","unstructured":"Ross IN, Bahari HMM, Turnberg LA: The pH gradient across mucus adherent to rat fundic mucosain vivo and the effect of potential damaging agents. Gastroenterology 81:713\u2013718, 1981","journal-title":"Gastroenterology"},{"key":"BF02282324_CR8","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1136\/gut.24.11.1030","volume":"24","author":"IN Ross","year":"1983","unstructured":"Ross IN, Turnberg LA: Studies of the mucus-bicarbonate barrier on rat fundic mucosa: The effects of luminal pH and a stabile prostaglandin analogue. Gut 24:1030\u20131033, 1983","journal-title":"Gut"},{"key":"BF02282324_CR9","first-page":"714","volume":"10","author":"GM Cummins","year":"1948","unstructured":"Cummins GM, Grossman MI, Ivy IC: An experimental study of the acid factor in ulceration of the gastrointestinal tract in dogs. Gastroenterology 10:714\u2013726, 1948","journal-title":"Gastroenterology"},{"key":"BF02282324_CR10","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0016-5085(81)80119-9","volume":"81","author":"E Kivilaakso","year":"1981","unstructured":"Kivilaakso E: High plasma HCO3 protects gastric mucosa against acute ulceration in the rat. Gastroenterology 81:921\u2013927, 1981","journal-title":"Gastroenterology"},{"key":"BF02282324_CR11","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1172\/JCI114330","volume":"84","author":"MC Chen","year":"1989","unstructured":"Chen MC, Sanders MJ, Amirian DA, Thomas LP, Kauffman G, Soll A-H: Prostaglandin E2 production by dispersed canine fundic mucosal cells: Contribution of macrophages and endothelial cells as major sources. J Clin Invest 84:1536, 1989","journal-title":"J Clin Invest"},{"key":"BF02282324_CR12","doi-asserted-by":"crossref","unstructured":"Burakoff R, Nastos E, Won S: Effects of PGF2a and indomethacin on rabbit small and large intestinal motilityin vivo. Am J Physiol 258:G231, 1990","DOI":"10.1152\/ajpgi.1990.258.2.G231"},{"key":"BF02282324_CR13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","volume":"231","author":"JR Vane","year":"1971","unstructured":"Vane JR: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (London) New Biol 231:232, 1971","journal-title":"Nature (London) New Biol"},{"key":"BF02282324_CR14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0016-5085(79)90004-0","volume":"77","author":"A Garner","year":"1977","unstructured":"Garner A, Flemstr\u00f6m G, Heylings JR: Effects of anti-inflammatory agents and prostaglandins on acid and bicarbonate secretions in the amphibian-isolated gastric mucosa. Gastroenterology 77:451, 1977","journal-title":"Gastroenterology"},{"key":"BF02282324_CR15","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0016-5085(79)90235-X","volume":"77","author":"A Robert","year":"1979","unstructured":"Robert A: Cytoprotection by prostaglandins. Gastroenterology 77:761, 1979","journal-title":"Gastroenterology"},{"key":"BF02282324_CR16","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0016-5085(82)80198-4","volume":"83","author":"E Lacy","year":"1983","unstructured":"Lacy E, Ito S: Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with prostaglandin. Gastroenterology 83:619\u2013625, 1983","journal-title":"Gastroenterology"},{"key":"BF02282324_CR17","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1007\/BF01536369","volume":"34","author":"T Ranta-Knuuttila","year":"1989","unstructured":"Ranta-Knuuttila T, Kiviluoto T, Hyv\u00e4rinen H, Lehtola A, Kivilaakso E: Prostaglandin protection against hemorrhage-induced gastric stress ulceration in the rat. Dig Dis Sci 34:1028\u20131034, 1989","journal-title":"Dig Dis Sci"},{"key":"BF02282324_CR18","first-page":"G57","volume":"264","author":"T Kiviluoto","year":"1993","unstructured":"Kiviluoto T, Ahonen M, B\u00e4ck N, H\u00e4pp\u00f6l\u00e4 O, Mustonen H, Paimela H, Kivilaakso E: Pre-epithelial mucus-HCO3 layer protects against intracellular acidosis in acid-exposed gastric mucosa. Am J Physiol 264(Gastrointest Liver Physiol 27):G57-G63, 1993","journal-title":"Am J Physiol"},{"key":"BF02282324_CR19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0002-9343(86)80005-5","volume":"81","author":"G Flemstr\u00f6m","year":"1986","unstructured":"Flemstr\u00f6m G: Gastroduodenal mucosal secretion of bicarbonate and mucus. Physiologic control and stimulation by prostaglandins. Am J Med 81:18\u201322, 1986","journal-title":"Am J Med"},{"key":"BF02282324_CR20","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/0016-5085(87)90444-6","volume":"93","author":"T Kitahora","year":"1987","unstructured":"Kitahora T, Guth PH: Effect of aspirin plus hydrochloric acid on the gastric mucosal microcirculation. Gastroenterology 93:810, 1987","journal-title":"Gastroenterology"},{"key":"BF02282324_CR21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0002-9610(85)80009-X","volume":"149","author":"SW Ashley","year":"1985","unstructured":"Ashley SW, Sonnenschein LA, Cheung LY: Focal gastric mucosal blood flow at the site of aspirin-induced ulceration. Am J Surg 149:53\u201359, 1985","journal-title":"Am J Surg"},{"key":"BF02282324_CR22","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/0016-5085(86)90195-2","volume":"91","author":"G Pihan","year":"1986","unstructured":"Pihan G, Majzoubi D, Housenschild C, Trier JS, Szabo S: Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16,16-dimethyl prostaglandin E2 or sodium thiosulfate. Gastroenterology 91:1415\u20131426, 1986","journal-title":"Gastroenterology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02282324.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02282324\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02282324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T08:46:08Z","timestamp":1586681168000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02282324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["BF02282324"],"URL":"https:\/\/doi.org\/10.1007\/bf02282324","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}