{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:34:04Z","timestamp":1790001244654,"version":"4.0.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Autonomic Research"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1007\/bf02292766","type":"journal-article","created":{"date-parts":[[2006,1,25]],"date-time":"2006-01-25T16:00:42Z","timestamp":1138204842000},"page":"351-355","source":"Crossref","is-referenced-by-count":107,"title":["The role of cardiac metaiodobenzylguanidine uptake in the differential diagnosis of parkinsonian syndromes"],"prefix":"10.1007","volume":"11","author":[{"given":"Stefan","family":"Braune","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF02292766_CR1","first-page":"358","volume":"22","author":"DM Wieland","year":"1981","unstructured":"Wieland DM, Brown LE, Tobes MC. Imaging the primate adrenal medulla with 1231 and 1311 meta-iodobenzylguanidine.J Nucl Med 1981; 22:358\u2013364.","journal-title":"J Nucl Med"},{"key":"BF02292766_CR2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00006231-199207000-00006","volume":"13","author":"KK Solanki","year":"1992","unstructured":"Solanki KK, Bomanji J, Moyes J, et al. A pharmacological guide to medicines which interfere with the biodistribution of radiolabelled meta-iodobenzylguanidine (MIBG).Nucl Med Commun 1992; 13:513\u2013521.","journal-title":"Nucl Med Commun"},{"key":"BF02292766_CR3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/BF00173043","volume":"21","author":"AR Wafelman","year":"1994","unstructured":"Wafelman AR, Hoefnagel CA, Maes RA, et al. Radioiodinated metaiodobenzylguanidine: a review of its biodistribution and pharmacokinetics, drug interactions, cytotoxicity and dosimetry.Eur J Nucl Med 1994; 21:545\u2013559.","journal-title":"Eur J Nucl Med"},{"key":"BF02292766_CR4","first-page":"114","volume":"34","author":"JV Glowniak","year":"1993","unstructured":"Glowniak JV, Kilty JE, Amara SG, et al. Evaluation of metaiodobenzylguanidine uptake by the norepinephrine, dopamine and serotonin transporters.J Nucl Med 1993; 34:114\u2013116.","journal-title":"J Nucl Med"},{"key":"BF02292766_CR5","first-page":"3920","volume":"47","author":"S Jaques","year":"1987","unstructured":"Jaques S, Tobes MC, Sisson JC. Sodium dependency of uptake of norepinephrine andm-iodobenzylquanidine into cultured human pheochromocytoma cells: evidence of uptake-one.Cancer Res 1987; 47:3920\u20133928.","journal-title":"Cancer Res"},{"key":"BF02292766_CR6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1021\/jm00368a008","volume":"27","author":"DM Wieland","year":"1984","unstructured":"Wieland DM, Mangner TJ, Inbasekaran MN, et al. Adrenal medulla imaging agents: a structure-distribution relationship study of radiolabeled aralkylguanidines.J Med Chem 1984; 27:149\u2013155.","journal-title":"J Med Chem"},{"key":"BF02292766_CR7","first-page":"275","volume":"29","author":"B Gasnier","year":"1986","unstructured":"Gasnier B, Roisin MP, Scherman D, et al. Uptake of metaiodobenzylguanidine by bovine chromaffin granule membranes.Mol Pharmacol 1986; 29:275\u2013280.","journal-title":"Mol Pharmacol"},{"key":"BF02292766_CR8","first-page":"1620","volume":"28","author":"JC Sisson","year":"1987","unstructured":"Sisson JC, Wieland DM, Sherman P, et al. Metaiodobenzylguanidine as an index of the adrenergic nervous system integrity and function.J Nucl Med 1987; 28:1620\u20131624.","journal-title":"J Nucl Med"},{"key":"BF02292766_CR9","first-page":"1625","volume":"28","author":"JC Sisson","year":"1987","unstructured":"Sisson JC, Shapiro B, Meyers L, et al. Metaiodobenzylguanidine to map scintigraphically the adrenergic nervous system in man.J Nucl Med 1987; 28:1625\u20131636.","journal-title":"J Nucl Med"},{"key":"BF02292766_CR10","first-page":"17","volume":"26","author":"S Jaques","year":"1985","unstructured":"Jaques S, Tobes MC. Comparison of the secretory mechanisms of meta-iodobenzylguanidine (MIBG) and norepinephrine (NE) from the cultured bovine adrenomedullary cells [abstract].J Nucl Med 1985; 26:17.","journal-title":"J Nucl Med"},{"key":"BF02292766_CR11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0002-8703(88)90251-7","volume":"116","author":"JC Sisson","year":"1988","unstructured":"Sisson JC, Lynch JJ, Johnson J, et al. Scintigraphic detection of regional disruption of adrenergic neurons in the heart.Am Heart J 1988; 116:67\u201376.","journal-title":"Am Heart J"},{"key":"BF02292766_CR12","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/01.CIR.79.3.634","volume":"79","author":"MW Dae","year":"1989","unstructured":"Dae MW, O'Connell JW, Botvinick EH, et al. Scintigraphic assessment of regional cardiac adrenergic innervation.Circulation 1989; 79:634\u2013644.","journal-title":"Circulation"},{"key":"BF02292766_CR13","first-page":"371","volume":"40","author":"A Satoh","year":"1999","unstructured":"Satoh A, Serita T, Seto M, et al. Loss of123I-MIBG uptake by the heart in Parkinson's disease: assessment of cardiac denervation and diagnostic value.J Nucl Med 1999; 40:371\u2013375.","journal-title":"J Nucl Med"},{"key":"BF02292766_CR14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0022-510X(97)00278-5","volume":"155","author":"M Yoshita","year":"1998","unstructured":"Yoshita M. Differentiation of idiopathic Parkinson's disease from striatonigral degeneration and progressive supranuclear palsy using iodine 123 metaiodobenzyl-guanidine myocardial scintigraphy.J Neurol Sci 1998; 155:60\u201367.","journal-title":"J Neurol Sci"},{"key":"BF02292766_CR15","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s002590050544","volume":"27","author":"J Taki","year":"2000","unstructured":"Taki J, Nakajima K, Hwang EH, et al. Peripheral sympathetic dysfunction in patients with Parkinson's disease without autonomic failure is heart selective and disease specific.Eur J Nucl Med 2000; 27:566\u2013573.","journal-title":"Eur J Nucl Med"},{"key":"BF02292766_CR16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-0404.1998.tb05957.x","volume":"97","author":"K Iwasa","year":"1998","unstructured":"Iwasa K, Nakalima K, Yoshikawa H, et al. Decreased myocardial 123I-MIBG uptake in Parkinson's disease.Acta Neurol Scand 1998; 97:303\u2013336.","journal-title":"Acta Neurol Scand"},{"key":"BF02292766_CR17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF02298955","volume":"11","author":"CJ Mathias","year":"2001","unstructured":"Mathias CJ, Senard JM, Braune S, et al. L-threo-dihydroxyphenylserine (L-threo-DOPS; droxidopa) in the management of neurogenic orthostatic hypotension: a multi-national, multi-centre dose ranging study in multiple system atrophy (MSA) and pure autonomic failure (PAF).Clin Auton Res 2001; 11:235\u2013242.","journal-title":"Clin Auton Res"},{"key":"BF02292766_CR18","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1212\/WNL.54.9.1877-a","volume":"54","author":"M Yoshita","year":"2000","unstructured":"Yoshita M, Braune S. Cardiac uptake of [123I]MIBG separates PD from multiple system atrophy.Neurology 2000; 54:1877\u20131878.","journal-title":"Neurology"},{"key":"BF02292766_CR19","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/S0140-6736(94)90113-9","volume":"343","author":"Y Ando","year":"1994","unstructured":"Ando Y, Obayashi K, Tanaka Y, et al. Radiolabelled metaiodobenzylguanidine in assessment of autonomic dysfunction.Lancet 1994; 343:984\u2013985.","journal-title":"Lancet"},{"key":"BF02292766_CR20","first-page":"402","volume":"34","author":"S Hakusui","year":"1994","unstructured":"Hakusui S, Yasuda T, Yanagi T, et al. [123I-MIBG myocardial scintigraphical analysis in patients with and without autonomic disorder].Rinsho Shinkeigaku 1994; 34:402\u2013404 [in Japanese].","journal-title":"Rinsho Shinkeigaku"},{"key":"BF02292766_CR21","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/0735-1097(94)00459-4","volume":"25","author":"A Langer","year":"1995","unstructured":"Langer A, Freeman MR, Josse RG, et al. Metaiodobenzylguanidine imaging in diabetes mellitus: assessment of cardiac sympathetic denervation and its relation to autonomic dysfunction and silent myocardial ischemia.J Am Coll Cardiol 1995; 25:610\u2013618.","journal-title":"J Am Coll Cardiol"},{"key":"BF02292766_CR22","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2337\/diab.44.5.543","volume":"44","author":"G Kreiner","year":"1995","unstructured":"Kreiner G, Wolzt M, Fasching P, et al. Myocardial m-[123I]iodobenzylguanidine scintigraphy for the assessment of adrenergic cardiac innervation in patients with IDDM: comparison with cardiovascular reflex tests and relationship to left ventricular function.Diabetes 1995; 44:543\u2013549.","journal-title":"Diabetes"},{"key":"BF02292766_CR23","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/BF00401768","volume":"38","author":"O Schnell","year":"1995","unstructured":"Schnell O, Kirsch CM, Stemplinger J, et al. Scintigraphic evidence for cardiac sympathetic dysinnervation in long-term IDDM patients with and without ECG-based autonomic neuropathy.Diabetologia 1995; 38:1345\u20131352.","journal-title":"Diabetologia"},{"key":"BF02292766_CR24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1365-2362.1990.tb01909.x","volume":"20","author":"JM Senard","year":"1990","unstructured":"Senard JM, Valet P, Durrieu G, et al. Adrenergic supersensitivity in parkinsonians with orthostatic hypotension.Eur J Clin Invest 1990; 20:613\u2013619.","journal-title":"Eur J Clin Invest"},{"key":"BF02292766_CR25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1600-0404.1998.tb05958.x","volume":"97","author":"S Braune","year":"1998","unstructured":"Braune S, Reinhardt M, Bathmann J, et al. Impaired cardiac uptake of meta-[123I]iodobenzylguanidine in Parkinson's disease with autonomic failure.Acta Neurol Scand 1998; 97:307\u2013314.","journal-title":"Acta Neurol Scand"},{"key":"BF02292766_CR26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s002590050548","volume":"27","author":"MJ Reinhardt","year":"2000","unstructured":"Reinhardt MJ, J\u00fcngling FD, Krause TM, et al. Scintigraphic differentiation between two forms of primary dysautonomia early after onset of autonomic dysfunction: value of cardiac and pulmonary123I-MIBG uptake.Eur J Nucl Med 2000; 27:595\u2013600.","journal-title":"Eur J Nucl Med"},{"key":"BF02292766_CR27","doi-asserted-by":"crossref","first-page":"338","DOI":"10.7326\/0003-4819-133-5-200009050-00009","volume":"133","author":"DS Goldstein","year":"2000","unstructured":"Goldstein DS, Holmes C, Li ST, et al. Cardiac sympathetic denervation in Parkinson disease.Ann Intern Med 2000; 133:338\u2013347.","journal-title":"Ann Intern Med"},{"key":"BF02292766_CR28","first-page":"71","volume":"41","author":"H Takatsu","year":"2000","unstructured":"Takatsu H, Nishida H, Matsuo H, et al. Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG.J Nucl Med 2000; 41:71\u201377.","journal-title":"J Nucl Med"},{"key":"BF02292766_CR29","first-page":"609","volume":"60","author":"K Wakabayashi","year":"1993","unstructured":"Wakabayashi K, Takahashi H, Ohama E, et al. Lewy bodies in the visceral autonomic nervous system in Parkinson's disease.Adv Neurol 1993; 60:609\u2013612.","journal-title":"Adv Neurol"},{"key":"BF02292766_CR30","first-page":"965","volume":"41","author":"K Wakabayashi","year":"1989","unstructured":"Wakabayashi K. Parkinson's disease: the distribution of Lewy bodies in the peripheral autonomic nervous system.No To Shinkei 1989; 41:965\u2013971 [English abstract].","journal-title":"No To Shinkei"},{"key":"BF02292766_CR31","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1056\/NEJM199703063361004","volume":"336","author":"DS Goldstein","year":"1997","unstructured":"Goldstein DS, Holmes C, Cannon R, et al. Sympathetic cardioneuropathy in dysautonomias.N Engl J Med 1997; 336:696\u2013702.","journal-title":"N Engl J Med"},{"key":"BF02292766_CR32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1001\/jama.284.1.39","volume":"284","author":"H Takatsu","year":"2000","unstructured":"Takatsu H, Nagashima K, Murase M, et al. Differentiating Parkinson's disease from multiple system atrophy by measuring cardiac iodine-123 metaiodobenzylguanidine accumulation.JAMA 2000; 284:44\u201345.","journal-title":"JAMA"},{"key":"BF02292766_CR33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/jnnp.67.2.189","volume":"67","author":"S Orimo","year":"1999","unstructured":"Orimo S, Ozawa E, Nakade S, et al. (123)I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's disease.J Neurol Neurosurg Psychiatry 1999; 67:189\u2013194.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"BF02292766_CR34","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1212\/WNL.53.5.1020","volume":"53","author":"S Braune","year":"1999","unstructured":"Braune S, Reinhardt M, Schnitzer R, et al. Cardiac uptake of [123I]MIBG separates Parkinson's disease from multiple system atrophy.Neurology 1999; 53;1020\u20131025.","journal-title":"Neurology"},{"key":"BF02292766_CR35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0022-510X(00)00279-3","volume":"175","author":"A Druschky","year":"2000","unstructured":"Druschky A, Hilz MJ, Platsch G, et al. Differentiation of Parkinson's disease and multiple system atrophy in early disease stages by means of I-123-MIBG-SPECT.J Neurol Sci 2000; 175:3\u201312.","journal-title":"J Neurol Sci"},{"key":"BF02292766_CR36","first-page":"II\/11","volume":"Suppl 2","author":"DJ Brooks","year":"2000","unstructured":"Brooks DJ. Morphological and functional imaging studies on the diagnosis and progression of Parkinson's disease.J Neurol 2000; (Suppl 2):II\/11\u2013II\/18.","journal-title":"J Neurol"},{"key":"BF02292766_CR37","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1093\/brain\/120.12.2187","volume":"120","author":"A Antonini","year":"1997","unstructured":"Antonini A, Leenders KL, Vontobel P, et al. Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease.Brain 1997; 120:2187\u20132195.","journal-title":"Brain"},{"key":"BF02292766_CR38","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/mds.870130212","volume":"13","author":"A Antonini","year":"1998","unstructured":"Antonini A, Kazumata K, Feigin A, et al. Differential diagnosis of parkinsonism with [18F]fluorodeoxyglucose and PET.Mov Disord 1998; 13:268\u2013274.","journal-title":"Mov Disord"},{"key":"BF02292766_CR39","first-page":"285","volume":"9","author":"C Brefel-Courbon","year":"1999","unstructured":"Brefel-Courbon C, Courbon F, Thalamas C, et al. Myocardial meta-[123I] iodobenzylguanidine (MIBG) uptake is different in Parkinson's disease and multiple system atrophy with autonomic failure [abstract].Clin Auton Res 1999; 9:285.","journal-title":"Clin Auton Res"}],"container-title":["Clinical Autonomic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02292766.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02292766\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02292766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T19:03:07Z","timestamp":1557946987000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02292766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["BF02292766"],"URL":"https:\/\/doi.org\/10.1007\/bf02292766","relation":{},"ISSN":["0959-9851","1619-1560"],"issn-type":[{"value":"0959-9851","type":"print"},{"value":"1619-1560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}