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Transfusion of hydroxocobalamin (OH\u2010Cbl) bound to normal plasma temporarily restored granulocyte bactericidal activity and increased cellular levels of the cobalamin coenzymes. Granulocyte function was also temporarily restored by oral Leucovorin. The defect appeared to be causally related to the patient's TC II deficiency and indirectly to a deficiency of cobalamin and folate coenzymes.<\/jats:p>","DOI":"10.1007\/bf02312515","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T06:26:55Z","timestamp":1139984815000},"page":"3-9","source":"Crossref","is-referenced-by-count":19,"title":["Granulocyte dysfunction in transcobalamin II deficiency responding to leucovorin or hydroxocobalamin\u2010plasma transfusion"],"prefix":"10.1002","volume":"3","author":[{"given":"R.","family":"Seger","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Zurich  Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijke","family":"Fr\u00e0ter\u2010Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Zurich  Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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