{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:03:55Z","timestamp":1761764635751},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1980,12,1]],"date-time":"1980-12-01T00:00:00Z","timestamp":344476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1980,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This paper reviews the 19 published studies that have utilized psychological assessments in determining the outcome of children with phenylketonuria who have discontinued a phenylalanine\u2010restricted diet. About half the studies showed that, after diet termination, the intellectual performance of children decreased, while the other studies indicated that the intellectual performance of the children did not change. Difficulties in the use of intelligence tests to answer questions about diet termination are outlined. Due to the methodological difficulties and the varying results reported, the issue concerning the safety of diet discontinuation remains unresolved. The conclusion is that the task now is to differentiate those children who should remain on the diet from those who may safely terminate.<\/jats:p>","DOI":"10.1007\/bf02312549","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T06:26:55Z","timestamp":1139984815000},"page":"149-153","source":"Crossref","is-referenced-by-count":61,"title":["Diet termination in children with phenylketonuria: a review of psychological assessments used to determine outcome"],"prefix":"10.1002","volume":"3","author":[{"given":"S. E.","family":"Waisbren","sequence":"first","affiliation":[{"name":"Developmental Evaluation Clinic (PKU Clinic) Children's Hospital Medical Center  300 Longwood Avenue Boston Massachusetts 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Schnell","sequence":"additional","affiliation":[{"name":"Developmental Evaluation Clinic (PKU Clinic) Children's Hospital Medical Center  300 Longwood Avenue Boston Massachusetts 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Developmental Evaluation Clinic (PKU Clinic) Children's Hospital Medical Center  300 Longwood Avenue Boston Massachusetts 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1980,12]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"PKU\u2014A Guide to Management","author":"Acosta P. B.","year":"1974"},{"key":"e_1_2_1_3_1","volume-title":"Psychological Testing","author":"Anastasi A.","year":"1976"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.43.232.745-b"},{"key":"e_1_2_1_5_1","first-page":"42","article-title":"Phenylketonuria and its variations: a review of recent development","volume":"115","author":"Blaskovics M. E.","year":"1971","journal-title":"Calif. Med."},{"key":"e_1_2_1_6_1","volume-title":"Stability and Change in Human Characteristics","author":"Bloom B. S.","year":"1964"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700013842"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00477051"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1976.39.3.835"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0370-4475(78)80119-1"},{"key":"e_1_2_1_11_1","first-page":"281","volume-title":"Am. Pediatr. Soc. and Soc. for Pediatr. Res.","author":"Frankenburg W. K.","year":"1970"},{"key":"e_1_2_1_12_1","first-page":"524","article-title":"Behavioral consequences of increased phenylalanine intake by phenylketonuric children: a pilot study describing a methodology","volume":"77","author":"Frankenburg W. K.","year":"1973","journal-title":"Am. J. Ment. Defic."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/221639a0"},{"key":"e_1_2_1_14_1","first-page":"539","article-title":"Treated phenylketonuria. Intelligence and blood phenylalanine levels","volume":"75","author":"Fuller R. N.","year":"1971","journal-title":"Am. J. Ment. Defic."},{"key":"e_1_2_1_15_1","first-page":"282","volume-title":"Am. Pediatr. Soc. and Soc. for Pediatr. Res.","author":"Goldstein A.","year":"1970"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(68)80007-1"},{"key":"e_1_2_1_17_1","first-page":"383","article-title":"Termination of phenylketonuria dietary therapy in 62 patients","volume":"7","author":"Hanley W. B.","year":"1973","journal-title":"Pediatr. Res."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197511272932204"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196201112660206"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1542\/peds.38.2.173","article-title":"Phenylketonuria: a study of human biochemical genetics","volume":"38","author":"Hsia D. Y. Y.","year":"1966","journal-title":"Pediatrics"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.42.222.198"},{"key":"e_1_2_1_22_1","first-page":"51","volume-title":"Treatment of Inborn Errors of Metabolism","author":"Hudson F. B.","year":"1973"},{"key":"e_1_2_1_23_1","first-page":"27","article-title":"The phenylketonuria controversy, 1968","volume":"59","author":"Johnson C. F.","year":"1969","journal-title":"J. Iowa Med. Soc."},{"key":"e_1_2_1_24_1","first-page":"109","volume-title":"Treatment of Inborn Errors of Metabolism","author":"Koch R.","year":"1973"},{"key":"e_1_2_1_25_1","first-page":"1084","article-title":"Perceptual\u2010motor functioning in children with phenylketonuria","volume":"131","author":"Koff E.","year":"1977","journal-title":"Am. J. Dis. Child."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80005-0"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720340035005"},{"key":"e_1_2_1_28_1","first-page":"257","volume-title":"Review of Child Development Research","author":"Levine M.","year":"1966"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.43.227.1"},{"key":"e_1_2_1_30_1","article-title":"Developmental changes in mental performance.","volume":"38","author":"McCali R. B.","year":"1973","journal-title":"Monogr. Soc. Res. Child. Dev."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02954680"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.2307\/3420702"},{"key":"e_1_2_1_33_1","first-page":"19","volume-title":"Treatment of Inborn Errors of Metabolism","author":"Parker C. E.","year":"1973"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0002-8223(21)06483-X","article-title":"Discontinuing the phenylalanine\u2010restricted diet in young children with phenylketonuria: psychosocial aspects","volume":"70","author":"Pueschel S. M.","year":"1977","journal-title":"J. Am. Diet. Assoc."},{"key":"e_1_2_1_35_1","first-page":"896","article-title":"Electroencephalographic findings in children with phenylketonuria","volume":"129","author":"Rolle\u2010Daya H.","year":"1975","journal-title":"Am. J. Dis. Child."},{"key":"e_1_2_1_36_1","volume-title":"Assessment of Children's Intelligence","author":"Sattler J.","year":"1974"},{"key":"e_1_2_1_37_1","volume-title":"DHEW Publication, No. (HSA) 79\u20105296","author":"Schuett V.","year":"1979"},{"key":"e_1_2_1_38_1","first-page":"937","article-title":"School behavior profile ratings of phenylketonuric children","volume":"72","author":"Seigal F.","year":"1967","journal-title":"Am. J. Ment. Defic."},{"key":"e_1_2_1_39_1","first-page":"141","volume-title":"Heritable Disorders of Amino Acid Metabolism: Patterns of Clinical Expression and Genetic Variation","author":"Shear C.","year":"1974"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456327701400126"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6139.723"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80046-X"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.2307\/1165594"},{"key":"e_1_2_1_44_1","first-page":"492","article-title":"Termination of dietary treatment for phenylketonuria","volume":"106","author":"Vandeman P.","year":"1963","journal-title":"Am. J. Dis. Child."},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1542\/peds.60.6.815","article-title":"Collaborative study of children treated for phenylketonuria: study design","volume":"60","author":"Williamson M.","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1976.tb04212.x"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02312549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02312549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T03:53:06Z","timestamp":1694922786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/BF02312549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,12]]}},"alternative-id":["10.1007\/BF02312549"],"URL":"https:\/\/doi.org\/10.1007\/bf02312549","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,12]]}}}