{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:12:43Z","timestamp":1759482763079},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[1987,3]]},"DOI":"10.1007\/bf02343219","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T19:16:56Z","timestamp":1142450216000},"page":"140-144","source":"Crossref","is-referenced-by-count":13,"title":["Prolonged indomethacin treatment in preterm infants with symptomatic patent ductus arteriosus: efficacy, drug level monitoring, and patient selection"],"prefix":"10.1007","volume":"146","author":[{"given":"A.","family":"Leonhardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Isken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G.","family":"K\u00fchl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W.","family":"Seyberth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02343219_CR1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1056\/NEJM198107093050203","volume":"305","author":"AR Brash","year":"1981","unstructured":"Brash AR, Hickey DE, Graham TP, Stahlman MT, Oates JA, Cotton RB (1981) Pharmacokinetics of indomethacin in the neonate. N Engl J Med 305:67\u201372","journal-title":"N Engl J Med"},{"key":"BF02343219_CR2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1748-1716.1983.tb07198.x","volume":"117","author":"S Erikson","year":"1983","unstructured":"Erikson S, Hagenfeldt L, Law D, Patrono C, Pinca E, Wennmalm A (1983) Effect of prostaglandin synthesis inhibitors on basal and carbon dioxide stimulated cerebral blood flow in man. Acta Physiol Scand 117:203\u2013211","journal-title":"Acta Physiol Scand"},{"key":"BF02343219_CR3","doi-asserted-by":"crossref","first-page":"341A","DOI":"10.1203\/00006450-198504000-01407","volume":"19","author":"GM Ferguson","year":"1985","unstructured":"Ferguson GM, Rhodes PG, Joransen JA (1985) Prolonged treatment of the patent ductus arteriosus (PDA) with indomethacin (im). Pediatr Res 19:341A","journal-title":"Pediatr Res"},{"key":"BF02343219_CR4","first-page":"33","volume":"26","author":"RJ Flower","year":"1974","unstructured":"Flower RJ (1974) Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev 26:33\u201367","journal-title":"Pharmacol Rev"},{"key":"BF02343219_CR5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000457389","volume":"4","author":"CA Friedman","year":"1982","unstructured":"Friedman CA, Parks BR, Rawson JE, Serwer GA, Anderson PAW (1982) Indomethacin and the preterm infant with a patent ductus arteriosus: relationship between plasma concentration and ductus closure. Dev Pharmacol Ther 4:37\u201346","journal-title":"Dev Pharmacol Ther"},{"key":"BF02343219_CR6","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0022-3476(83)80022-5","volume":"102","author":"WM Gersony","year":"1983","unstructured":"Gersony WM, Peckham GJ, Ellison RC, Miettinen OS, Nadas AS (1983) Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study. J Pediatr 102:895\u2013906","journal-title":"J Pediatr"},{"key":"BF02343219_CR7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00974058","volume":"1","author":"A Giedion","year":"1973","unstructured":"Giedion A, Hafliger H, Dangel P (1973) Acute pulmonary X-ray changes in hyaline membrane disease treated with artificial ventilation and positive end-expiratory pressure (PEP). Pediatr Radiol 1:145\u2013152","journal-title":"Pediatr Radiol"},{"key":"BF02343219_CR8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-3476(80)80337-4","volume":"96","author":"AC Gittenberger-de Groot","year":"1980","unstructured":"Gittenberger-de Groot AC, van Ertbruggen I, Moulaert AJMG, Harinck E (1980) The ductus arteriosus in the preterm infant: histologic and clinical observations. J Pediatr 96:88\u201393","journal-title":"J Pediatr"},{"key":"BF02343219_CR9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF00442142","volume":"143","author":"G K\u00fchl","year":"1985","unstructured":"K\u00fchl G, Wille L, Bolkenius M, Seyberth HW (1985) Intestinal perforation associated with indomethacin treatment in premature infants. Eur J Pediatr 143:213\u2013216","journal-title":"Eur J Pediatr"},{"key":"BF02343219_CR10","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1056\/NEJM198203043060903","volume":"306","author":"L Mahony","year":"1982","unstructured":"Mahony L, Carnero V, Brett C, Heymann MA, Clyman RI (1982) Prophylactic indomethacin therapy for patent ductus arteriosus in very-low-birth-weight infants. N Engl J Med 306:506\u2013510","journal-title":"N Engl J Med"},{"key":"BF02343219_CR11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0022-3476(84)80380-7","volume":"105","author":"M Mellander","year":"1984","unstructured":"Mellander M, Leheup B, Lindstrom DP, Palme C, Graham TP, Stahlman MT, Cotton RB (1984) Recurrence of symptomatic patent ductus arteriosus in extremely premature infants, treated with indomethacin. J Pediatr 105:138\u2013143","journal-title":"J Pediatr"},{"key":"BF02343219_CR12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0022-3476(81)80479-9","volume":"99","author":"TA Merritt","year":"1981","unstructured":"Merritt TA, Harris JP, Roghman K, Wood B, Campanella V, Alexson C, Manning J, Shapiro DL (1981) Early closure of the patent ductus arteriosus in very low-birth-weight infants: a controlled trial. J Pediatr 99:281\u2013286","journal-title":"J Pediatr"},{"key":"BF02343219_CR13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM196702162760701","volume":"276","author":"WH Northway","year":"1967","unstructured":"Northway WH, Rosan RC, Porter DY (1967) Pulmonary disease following respirator therapy of hyaline membrane disease: bronchopulmonary dysplasia. N Engl J Med 276:357\u2013368","journal-title":"N Engl J Med"},{"issue":"Suppl 2","key":"BF02343219_CR14","first-page":"43","volume":"4","author":"HC Oppermann","year":"1983","unstructured":"Oppermann HC, Ulmer HE, Wille L (1983) Radiographic assessment of patent ductus arteriosus in preterm infants. Pediatr Cardiol [Suppl 2] 4:43\u201345","journal-title":"Pediatr Cardiol"},{"key":"BF02343219_CR15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/adc.58.4.267","volume":"58","author":"P Rudd","year":"1983","unstructured":"Rudd P, Montanez P, Hallidie-Smith K, Silverman M (1983) Indomethacin treatment for patent ductus arteriosus in very low birth weight infants: double blind trial. Arch Dis Child 58:267\u2013270","journal-title":"Arch Dis Child"},{"issue":"Suppl 2","key":"BF02343219_CR16","first-page":"53","volume":"4","author":"GA Serwer","year":"1983","unstructured":"Serwer GA (1983) Detection and quantitation of ductus arteriosus flow using continuous wave doppler ultrasonography. Pediatr Cardiol [Suppl 2] 4:53\u201359","journal-title":"Pediatr Cardiol"},{"key":"BF02343219_CR17","first-page":"127","volume":"2","author":"HW Seyberth","year":"1982","unstructured":"Seyberth HW, M\u00fcller H, Wille L, Pl\u00fcckthun H, Wolf D, Ulmer HE (1982) Recovery of prostaglandin production associated with reopening of the ductus arteriosus after indomethacin treatment in preterm infants with respiratory distress syndrome. Pediatr Pharmacol 2:127\u2013141","journal-title":"Pediatr Pharmacol"},{"issue":"Suppl 2","key":"BF02343219_CR18","first-page":"81","volume":"4","author":"HW Seyberth","year":"1983","unstructured":"Seyberth HW, Wille L, Wolf D, Ulmer HE (1983) Indomethacin in preterm infants with patent ductus arteriosus: disposition, benefit and side effects. Pediatr Cardiol [Suppl 2] 4:81\u201384","journal-title":"Pediatr Cardiol"},{"key":"BF02343219_CR19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00496793","volume":"141","author":"HW Seyberth","year":"1983","unstructured":"Seyberth HW, Knapp G, Wolf D, Ulmer HE (1983) Introduction of plasma indomethacin level monitoring and evaluation of an effective threshold level in very low birth weight infants with symptomatic patent ductus arteriosus. Eur J Pediatr 141:71\u201376","journal-title":"Eur J Pediatr"},{"key":"BF02343219_CR20","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0022-3476(83)80736-7","volume":"103","author":"HW Seyberth","year":"1984","unstructured":"Seyberth HW, Rascher W, Hackenthal R, Wille L (1984) Effect of prolonged indomethacin therapy on renal function and selected vasoactive hormones in very-low-birth-weight infants with symptomatic patent ductus arteriosus. J Pediatr 103:979\u2013984","journal-title":"J Pediatr"},{"key":"BF02343219_CR21","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1203\/00006450-198406000-00007","volume":"18","author":"HW Seyberth","year":"1984","unstructured":"Seyberth HW, M\u00fcller H, Ulmer HE, Wille L (1984) Urinary excretion rates of 6-keto-PGF1\u03b1 in preterm infants recovering from respiratory distress with and without patent ductus arteriosus. Pediatr Res 18:520\u2013524","journal-title":"Pediatr Res"},{"key":"BF02343219_CR22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000457401","volume":"4","author":"S Shankaran","year":"1982","unstructured":"Shankaran S, Pantoja A, Poland RL (1982) Indomethacin and bilirubin-albumin binding. Dev Pharmacol Ther 4:124\u2013131","journal-title":"Dev Pharmacol Ther"},{"key":"BF02343219_CR23","first-page":"167","volume":"3","author":"HE Ulmer","year":"1983","unstructured":"Ulmer HE, Knapp G, Wolf D, Wille L, Seyberth HW (1983) Aortic flow velocity curves and the follow up of symptomatic patent ductus arteriosus in preterm infants during therapeutic interventions. Pediatr Pharmacol 3:167\u2013174","journal-title":"Pediatr Pharmacol"},{"key":"BF02343219_CR24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1542\/peds.67.5.647","volume":"67","author":"RM Yanagi","year":"1981","unstructured":"Yanagi RM, Wilson A, Newfield EA, Aziz KU, Hunt CE (1981) Indomethacin treatment for symptomatic patent ductus arteriosus: a double blind control study. Pediatrics 67:647\u2013652","journal-title":"Pediatrics"},{"key":"BF02343219_CR25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0022-3476(81)80560-4","volume":"98","author":"TF Yeh","year":"1981","unstructured":"Yeh TF, Luken JA, Thalji A, Raval D, Carr I, Pildes RS (1981) Intravenous indomethacin therapy in premature infants with persistent ductus arteriosus \u2014 a double-blind controlled study. J Pediatr 98:137\u2013145","journal-title":"J Pediatr"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02343219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02343219\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02343219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T19:39:37Z","timestamp":1683401977000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02343219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,3]]}},"alternative-id":["BF02343219"],"URL":"https:\/\/doi.org\/10.1007\/bf02343219","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}