{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:32:21Z","timestamp":1768545141815,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1994,12,1]],"date-time":"1994-12-01T00:00:00Z","timestamp":786240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Gastroenterol"],"published-print":{"date-parts":[[1994,12]]},"DOI":"10.1007\/bf02349281","type":"journal-article","created":{"date-parts":[[2006,3,16]],"date-time":"2006-03-16T08:26:03Z","timestamp":1142497563000},"page":"745-750","source":"Crossref","is-referenced-by-count":9,"title":["Elevated urokinase-type plasminogen activator plasma levels are associated with deterioration of liver function but not with hepatocellular carcinoma"],"prefix":"10.1007","volume":"29","author":[{"given":"Seiji","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souhei","family":"Ouguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02349281_CR1","first-page":"1","volume":"3","author":"T Astrup","year":"1978","unstructured":"Astrup T. Fibrinolysis: An overview. Progr Chem Fibrinol Thrombol 1978;3:1\u201357.","journal-title":"Progr Chem Fibrinol Thrombol"},{"key":"BF02349281_CR2","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1083\/jcb.106.4.1241","volume":"106","author":"CA H\u00e9bert","year":"1988","unstructured":"H\u00e9bert CA, Baker JB. Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton: Colocalization of cell surface urokinase with vinculin. J Cell Biol 1988;106:1241\u20131247.","journal-title":"J Cell Biol"},{"key":"BF02349281_CR3","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1083\/jcb.104.4.1085","volume":"104","author":"J P\u00f6ll\u00e4nen","year":"1987","unstructured":"P\u00f6ll\u00e4nen J, Saksela O, Salonen EM, et al. Distinet localization of urokinase-type plasminogen activator and its Type 1 inhibitor under cultured human fibroblasts and sarcoma cells. J Cell Biol 1987;104:1085\u20131096.","journal-title":"J Cell Biol"},{"key":"BF02349281_CR4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1083\/jcb.106.1.87","volume":"106","author":"J P\u00f6ll\u00e4nen","year":"1988","unstructured":"P\u00f6ll\u00e4nen J, Hedman K, Nielsen, LS et al. Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts. J Cell Biol 1988;106:87\u201395.","journal-title":"J Cell Biol"},{"key":"BF02349281_CR5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(88)90567-3","volume":"53","author":"B Furie","year":"1988","unstructured":"Furie B, Furie BC. The molecular basis of blood coagulation. Cell 1988;53:505\u2013518.","journal-title":"Cell"},{"key":"BF02349281_CR6","doi-asserted-by":"crossref","first-page":"9476","DOI":"10.1016\/S0021-9258(19)76565-X","volume":"263","author":"BS Knudsen","year":"1988","unstructured":"Knudsen BS, Nachman RL. Matrix plasminogen activator inhibitor. J Biol Chem 1988;263:9476\u20139481.","journal-title":"J Biol Chem"},{"key":"BF02349281_CR7","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1016\/S0021-9258(19)81690-3","volume":"264","author":"J Wojta","year":"1989","unstructured":"Wojta J, Hoover RL, Daniel TO. Vascular origin determines plasminogen activator expression in human endothelial cells. Renal endothelial cells produce large amounts of single chain urokinase type plasminogen activator. J Biol Chem 1989;264: 2846\u20132852.","journal-title":"J Biol Chem"},{"key":"BF02349281_CR8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0378-1119(88)90447-7","volume":"69","author":"SM Cheng","year":"1988","unstructured":"Cheng SM, Lee SG, Kalyan NK, et al. Isolation of a human cDNA of urokinase and its expression in COS-1 cells. Gene 1988;69:357\u2013363.","journal-title":"Gene"},{"key":"BF02349281_CR9","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0049-3848(86)90019-8","volume":"44","author":"A Kjaeldgaard","year":"1986","unstructured":"Kjaeldgaard A, Larsson B, \u00c5stedt B. Release of both urokinase and tissue plasminogen activator from veins in vitro. Thromb Res 1986;44:729\u2013737.","journal-title":"Thromb Res"},{"key":"BF02349281_CR10","doi-asserted-by":"crossref","first-page":"12382","DOI":"10.1016\/S0021-9258(17)39036-1","volume":"260","author":"S Kasai","year":"1985","unstructured":"Kasai S, Arimura H, Nishida M, et al. Primary structure of single-chain pro-urokinase. J Biol Chem 1985;260:12382\u201312389.","journal-title":"J Biol Chem"},{"key":"BF02349281_CR11","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1016\/S0021-9258(18)92834-6","volume":"266","author":"WF Mangel","year":"1991","unstructured":"Mangel WF, Lin B, Ramakrishnan V. Conformation of one- and two-chain high molecular weight urokinase analyzed by small-angle neutron scattering and vacuum ultraviolet circular dichroism. J Biol Chem 1991;266:9408\u20139412.","journal-title":"J Biol Chem"},{"key":"BF02349281_CR12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.104.4.801","volume":"104","author":"F Blasi","year":"1987","unstructured":"Blasi F, Vassalli JD, Dan\u00f8 K. Urokinase-type plasminogen activator: Proenzyme, receptor, and inhibitors. J Cell Biol 1987;104: 801\u2013804.","journal-title":"J Cell Biol"},{"key":"BF02349281_CR13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF00049524","volume":"9","author":"JE Testa","year":"1990","unstructured":"Testa JE, Quigley JP. The role of urokinase-type plasminogen activator in aggressive tumor cell behavior. Cancer Metastasis Rev 1990;9:353\u2013367.","journal-title":"Cancer Metastasis Rev"},{"key":"BF02349281_CR14","first-page":"345","volume":"65","author":"JG Corasanti","year":"1980","unstructured":"Corasanti JG, Celik C, Camiolo SM, et al. Plasminogen activator content of human colon tumors and normal mucosae: Separation of enzymes and partial purification. J Natl Cancer Inst 1980;65: 345\u2013351.","journal-title":"J Natl Cancer Inst"},{"key":"BF02349281_CR15","first-page":"841","volume":"40","author":"G Markus","year":"1980","unstructured":"Markus G, Takita H, Camiolo SM, et al. Content and characterization of plasminogen activators in human lung tumors and normal lung tissue. Cancer Res 1980;40:841\u2013848.","journal-title":"Cancer Res"},{"key":"BF02349281_CR16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/ijc.2910270211","volume":"27","author":"SM Camiolo","year":"1981","unstructured":"Camiolo SM, Markus G, Evers JL, et al. Plasminogen activator content of neoplastic and benign human prostate tissues: Fibrin augmentation of an activator activity. Int J Cancer 1981;27: 191\u2013198.","journal-title":"Int J Cancer"},{"key":"BF02349281_CR17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0268-9499(90)90001-Z","volume":"4","author":"F J\u00e4nicke","year":"1990","unstructured":"J\u00e4nicke F, Schmitt M, Hafter R, et al. Urokinase-type plasminogen activator antigen is a predictor of early replase in breast cancer. Fibrinolysis 1990;4:69\u201378.","journal-title":"Fibrinolysis"},{"key":"BF02349281_CR18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1055\/s-0038-1660082","volume":"54","author":"JC Kirchheimer","year":"1985","unstructured":"Kirchheimer JC, Huber K, Polterauer P, et al. Urokinase antigen in plasma of patients with liver cirrhosis and hepatoma. Thromb Haemostasis 1985;54:617\u2013618.","journal-title":"Thromb Haemostasis"},{"key":"BF02349281_CR19","first-page":"500","volume":"102","author":"EG Levin","year":"1983","unstructured":"Levin EG, Fair DS, Loskutoff DJ. Human hepatoma cell line plasminogen activator. J Lab Clin Med 1983;102:500\u2013508.","journal-title":"J Lab Clin Med"},{"key":"BF02349281_CR20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4044\/joma1947.103.3_155","volume":"103","author":"T Tsuji","year":"1991","unstructured":"Tsuji T, Higashi T, Yamada G, et al. Indication of orthotopic liver transplantation for adult liver diseases (in Japanese). Okayama Igakkai Zasshi 1991;103:155\u2013165.","journal-title":"Okayama Igakkai Zasshi"},{"key":"BF02349281_CR21","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","volume":"60","author":"RNH Pugh","year":"1973","unstructured":"Pugh RNH, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646\u2013649.","journal-title":"Br J Surg"},{"key":"BF02349281_CR22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1172\/JCI104953","volume":"43","author":"AP Fletcher","year":"1964","unstructured":"Fletcher AP, Biederman O, Moore D, et al. Abnormal Plasminogen-plasmin system activity (fibrinolysis) in patients with hepatic cirrhosis: Its cause and consequences. J Clin Invest 1964;43:681\u2013695.","journal-title":"J Clin Invest"},{"key":"BF02349281_CR23","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1136\/jcp.37.7.772","volume":"37","author":"NA Booth","year":"1984","unstructured":"Booth NA, Anderson JA, Bennett B. Plasminogen activators in alcoholic cirrhosis: Demonstration of increased tissue type and urokinase type activator. J Clin Pathol 1984;37:772\u2013777.","journal-title":"J Clin Pathol"},{"key":"BF02349281_CR24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1055\/s-0038-1646877","volume":"62","author":"C Tran-Thang","year":"1989","unstructured":"Tran-Thang C, Fasel-Felley J, Pralong G, et al. Plasminogen activators and plasminogen activator inhibitors in liver deficiencies caused by chronic alcoholism or infectious hepatitis. Thromb Haemost 1989;62:651\u2013653.","journal-title":"Thromb Haemost"},{"key":"BF02349281_CR25","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0049-3848(91)90022-O","volume":"62","author":"K Huber","year":"1991","unstructured":"Huber K, Kirchheimer JC, Korninger C, et al. Hepatic synthesis and clearance of components of the fibrinolytic system in healthy volunteers and in patients with different stages of liver cirrhosis. Thromb Res 1991;62:491\u2013500.","journal-title":"Thromb Res"},{"key":"BF02349281_CR26","first-page":"6563","volume":"21","author":"T Nogami","year":"1987","unstructured":"Nogami T, Matsuno K, Kajii M, et al. Studies on metabolic fate of PPA in rats: (1) Absorption, distribution, metabolism, and excretion after single intravenous administration of125I-PPA (in Japanese). Kiso To Rinsho (Clin Report) 1987;21:6563\u20136578.","journal-title":"Kiso To Rinsho"},{"key":"BF02349281_CR27","first-page":"6579","volume":"21","author":"T Nogami","year":"1987","unstructured":"Nogami T, Matsuno K, Kasai S, et al. Studies on metabolic fate of PPA in rats: (2) Absorption, distribution, metabolism, and excretion after five successive intravenous administrations of125I-PPA (in Japanese) Kiso To Rinsho (Clin Report) 1987;21: 6579\u20136586.","journal-title":"Kiso To Rinsho"},{"key":"BF02349281_CR28","first-page":"877","volume":"15","author":"T Nogami","year":"1986","unstructured":"Nogami T, Tsukada M, Tanaka K, et al. Studies on metabolic fate of UK in rats: Absorption, distribution, metabolism, and excretion after single intravenous administration of125I-UK (in Japanese). Igaku To Yakugaku (J Med Pharmaceut Sci) 1986;15: 877\u2013898.","journal-title":"Igaku To Yakugaku"},{"key":"BF02349281_CR29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-0038-1661128","volume":"52","author":"D Collen","year":"1984","unstructured":"Collen D, De Cock F, Lijnen HR. Biological and thrombolytic properties of proenzyme and active forms of human urokinase-11. Turnover of natural and recombinant urokinase in rabbits and squirrel monkeys. Thromb Haemost 1984;52:24\u201326.","journal-title":"Thromb Haemost"},{"key":"BF02349281_CR30","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1182\/blood.V69.5.1315.1315","volume":"69","author":"SL Hersch","year":"1987","unstructured":"Hersch SL, Kunelis T, Francis RB Jr. The pathogenesis of accelerated fibrinolysis in liver cirrhosis: A critical role for tissue plasminogen activator inhibition. Blood 1987;69:1315\u20131319.","journal-title":"Blood"}],"container-title":["Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02349281.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02349281\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02349281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T23:47:22Z","timestamp":1627170442000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02349281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["BF02349281"],"URL":"https:\/\/doi.org\/10.1007\/bf02349281","relation":{},"ISSN":["0944-1174","1435-5922"],"issn-type":[{"value":"0944-1174","type":"print"},{"value":"1435-5922","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}