{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:04:23Z","timestamp":1782961463337,"version":"3.54.5"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur. J. Clin. Microbiol. Infect. Dis."],"published-print":{"date-parts":[[1993,1]]},"DOI":"10.1007\/bf02389870","type":"journal-article","created":{"date-parts":[[2006,4,10]],"date-time":"2006-04-10T09:32:06Z","timestamp":1144661526000},"page":"S6-S8","source":"Crossref","is-referenced-by-count":87,"title":["Pharmacodynamics of antimicrobial agents as a Basis for Determining Dosage Regimens"],"prefix":"10.1007","volume":"12","author":[{"given":"W.","family":"Craig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF02389870_CR1","unstructured":"Craig WA, Ebert SC: Killing and regrowth of bacteria in vitro: a review. Scandinavian Journal of Infectious Diseases 1991, Supplement 74: 63\u201370."},{"key":"BF02389870_CR2","first-page":"403","volume-title":"Antibiotics in laboratory medicine","author":"WA Craig","year":"1991","unstructured":"Craig WA, Gudmundsson S: Postantibiotic effect. In: Lorian V (ed): Antibiotics in laboratory medicine. Williams & Wilkins, Baltimore, 1991, p. 403\u2013431."},{"key":"BF02389870_CR3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/infdis\/157.2.287","volume":"157","author":"B Vogelman","year":"1988","unstructured":"Vogelman B, Gudmundsson S, Turnidge J, Leggett J, Craig WA: In vivo postantibiotic effect in a thigh infection in neutropenic mice. Journal of Infectious Diseases 1988, 157: 287\u2013298.","journal-title":"Journal of Infectious Diseases"},{"key":"BF02389870_CR4","unstructured":"Odenholt-Tornqvist I, Holm SE, Cars O: Pharmacodynamic effects of subinhibitory antibiotic concentrations. Scandinavian Journal of Infectious Diseases 1991, Supplement 74: 94\u2013101."},{"key":"BF02389870_CR5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/clinids\/3.1.38","volume":"3","author":"PJ McDonald","year":"1981","unstructured":"McDonald PJ, Wetherall BL, Pruul H: Postantibiotic leukocyte enhancement: increased susceptibility of bacteria pretreated with antibiotics to activity of leukocytes. Reviews of Infectious Diseases 1981, 3: 38\u201344.","journal-title":"Reviews of Infectious Diseases"},{"issue":"Supplement 3","key":"BF02389870_CR6","first-page":"49","volume":"1","author":"GG Jackson","year":"1988","unstructured":"Jackson GG, Diakos GL, Lolans VT: First-exposure effect of netilmicin on bacterial susceptibility as a basis for modifying the dosage regimen of aminoglycoside antibiotics. Journal of Drug Development 1988, 1, Supplement 3: 49\u201354.","journal-title":"Journal of Drug Development"},{"key":"BF02389870_CR7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/infdis\/159.2.281","volume":"159","author":"JE Leggett","year":"1989","unstructured":"Leggett JE, Fantin B, Ebert SC, Totsuka K, Vogelman B, Craig WA: Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection models. Journal of Infectious Diseases 1989, 159: 281\u2013292.","journal-title":"Journal of Infectious Diseases"},{"key":"BF02389870_CR8","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/BF01963774","volume":"8","author":"R Roosendaal","year":"1989","unstructured":"Roosendaal R, Bakker-Woudenberg IAJM, van den Berghe-van Raffe M Vink-van den Berg JC, Michel MF: Impact of the dosage schedule on the efficacy of ceftazidime, gentamicin and ciprofloxacin inKlebsiella pneumoniae pneumonia and septicemia in leukopenic rats. European Journal of Clinical Microbiology & Infectious Diseases 1989, 8: 878\u2013887.","journal-title":"European Journal of Clinical Microbiology & Infectious Diseases"},{"key":"BF02389870_CR9","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1128\/AAC.31.7.1054","volume":"31","author":"J Blaser","year":"1987","unstructured":"Blaser J, Stone BB, Groner MC, Zinner SH: Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance. Antimicrobial Agents and Chemotherapy 1987, 31: 1054\u20131060.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"BF02389870_CR10","unstructured":"Tulkens PM: Efficacy and safety of aminoglycosides once-a-day: experimental and clinical data. Scandinavian Journal of Infectious Diseases 1991, Supplement 74: 249\u2013257."}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02389870.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02389870\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02389870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T12:07:37Z","timestamp":1558094857000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02389870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":10,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["BF02389870"],"URL":"https:\/\/doi.org\/10.1007\/bf02389870","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}