{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:48:42Z","timestamp":1778629722431,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1980,3,1]],"date-time":"1980-03-01T00:00:00Z","timestamp":320716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[1980,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perianal disease is a frequent manifestation of Crohn's disease and occasionally is the presenting symptom. However, most lesions are or become asymptomatic and remain so for many years. A series of 109 patients with perianal fissures and fistulas has been followed for 10 years. Fourteen have died, 7 from unrelated disorders. Ten have had an excision of the rectum but only 5 for perianal disease. Of the remaining 85 patients, 24 asymptomatic patients were not reexamined, and 61 were investigated extensively by sigmoidoscopy biopsy or manometry. Many fissures and most fistulas had healed, but some had progressed to some degree of anal stenosis, usually asymptomatic. A very conservative policy is proposed.<\/jats:p>","DOI":"10.1007\/bf02393577","type":"journal-article","created":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T18:36:10Z","timestamp":1147372570000},"page":"203-207","source":"Crossref","is-referenced-by-count":89,"title":["Perianal Crohn's disease"],"prefix":"10.1002","volume":"4","author":[{"given":"John","family":"Alexander\u2010Williams","sequence":"first","affiliation":[{"name":"The General Hospital Steelhouse Lane B4 6NH Birmingham England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Buchmann","sequence":"additional","affiliation":[{"name":"The General Hospital Steelhouse Lane B4 6NH Birmingham England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1980,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"156","article-title":"Results of an experimental and histological investigation into seventy\u2010five cases of rectal fistulae","volume":"14","author":"Gabriel W.B.","year":"1921","journal-title":"Proc. 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