{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:35:41Z","timestamp":1778646941425,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[1996,8]]},"DOI":"10.1007\/bf02505247","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T12:34:11Z","timestamp":1160570051000},"page":"517-521","source":"Crossref","is-referenced-by-count":34,"title":["Influence of topical photodynamic therapy with 5-aminolevulinic acid on porphyrin metabolism"],"prefix":"10.1007","volume":"288","author":[{"given":"Clemens","family":"Fritsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Verwohlt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Bolsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ruzicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Goerz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF02505247_CR1","first-page":"69","volume":"44","author":"M Landthaler","year":"1993","unstructured":"Landthaler M, R\u00fcck A, Szeimies RM (1993) Photodynamische Therapie von Tumoren der Haut. Hautarzt 44:69\u201374","journal-title":"Hautarzt"},{"key":"BF02505247_CR2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/oso\/9780198555605.003.0012","volume-title":"Excited states and free radicals in biology and medicine","author":"RV Bensasson","year":"1993","unstructured":"Bensasson RV, Land EJ, Truscott TG (1993) Excited states and free radicals in biology and medicine, Oxford University Press. Oxford, pp 322\u2013345"},{"key":"BF02505247_CR3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1751-1097.1987.tb04749.x","volume":"46","author":"DP Valenzeno","year":"1987","unstructured":"Valenzeno DP (1987) Photomodification of biological membranes with emphasis on singlet oxygen mechanism. Photochem Photobiol 46:147\u2013160","journal-title":"Photochem Photobiol"},{"key":"BF02505247_CR4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/1011-1344(90)80002-F","volume":"5","author":"C Salet","year":"1990","unstructured":"Salet C, Moreno G (1990) Photosensitization of mitochondria. Molecular and cellular aspects. J Photochem Photobiol Biol B 5:133\u2013150","journal-title":"J Photochem Photobiol Biol B"},{"key":"BF02505247_CR5","unstructured":"Goetz AE, Feyh J, M\u00fcller W, Fritsch C, Kastenbauer E, Brendel W (1990) Photodynamische Lasertherapie am Patienten\u2014Photosensibilisatorfluoreszenz und photodynamisch induzierte Perfusions\u00e4nderungen. Langenbecks Arch Chir Suppl Chir Forum: 259\u2013265"},{"key":"BF02505247_CR6","first-page":"315","volume-title":"Fortschritte der operativen und onkologischen Dermatologie","author":"C Fritsch","year":"1994","unstructured":"Fritsch C, Lumper W, Kuhnle GEH, Abels C, Goetz AE (1994) Durchblutung von Tumoren vor und nach Photodynamischer Therapie, gemessen mit der Natrium-Fluoreszein-Fluxmetrie. In: Tilgen W, Petzoldt D (eds) Fortschritte der operativen und onkologischen Dermatologie. Springer, Berlin Heidelberg New York, pp 315\u2013320"},{"key":"BF02505247_CR7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/jnci\/85.6.443","volume":"85","author":"HI Pass","year":"1993","unstructured":"Pass HI (1993) Photodynamic therapy in oncology: mechanisms and clinical use. J Natl Cancer Inst 85:443\u2013453","journal-title":"J Natl Cancer Inst"},{"key":"BF02505247_CR8","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/bjc.1994.416","volume":"70","author":"M Al-Laith","year":"1994","unstructured":"Al-Laith M, Matthews EK (1994) Calcium-dependent photodynamic action of di- and tetrasulphonated aluminium phthalocyanine on normal and tumour-derived rat pancreatic exocrine cells. Br J Cancer 70:893\u2013899","journal-title":"Br J Cancer"},{"key":"BF02505247_CR9","first-page":"4501","volume":"50","author":"O Santoro","year":"1990","unstructured":"Santoro O, Bandieramonte G, Melloni E, Marchesini R (1990) Photodynamic therapy by topical meso-tetraphenylporphine-sulfate tetrasodium salt administration in superficial basal cell carcinomas. Cancer Res 50:4501\u20134503","journal-title":"Cancer Res"},{"key":"BF02505247_CR10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/1011-1344(90)85083-9","volume":"6","author":"JC Kennedy","year":"1990","unstructured":"Kennedy JC, Pottier RH, Pross DC (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol Biol 6: 143\u2013148","journal-title":"J Photochem Photobiol Biol"},{"key":"BF02505247_CR11","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/1523-1747.ep12324377","volume":"105","author":"RM Szeimies","year":"1995","unstructured":"Szeimies RM, Abels C, Fritsch C, Karrer S, Steinbach P, B\u00e4umler W, Goerz G, Goetz AE, Landthaler M (1995) Wave-length dependency of photodynamic effects after sensitization with 5-aminolevulinic acid in vitro and in vivo. J Invest Dermatol 105:672\u2013677","journal-title":"J Invest Dermatol"},{"key":"BF02505247_CR12","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/bjc.1994.112","volume":"69","author":"F Cairnduff","year":"1994","unstructured":"Cairnduff F, Stringer, MR, Hudson EJ, Ash DV, Brown SB (1994) Superficial photodynamic therapy with topical 5-aminolevulinic acid for superficial primary and secondary skin cancer. Br J Cancer 69:605\u2013608","journal-title":"Br J Cancer"},{"key":"BF02505247_CR13","first-page":"713","volume":"69","author":"C Fritsch","year":"1994","unstructured":"Fritsch C, Lehmann P, Bolsen K, Ruzicka T, Goerz G (1994) Photodynamische Diagnostik und Photodynamische Therapie von aktinischen Keratosen. H+G 69:713\u2013716","journal-title":"H+G"},{"key":"BF02505247_CR14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0190-9622(93)70002-B","volume":"28","author":"P Wolf","year":"1993","unstructured":"Wolf P, Rieger E, Kerl H (1993) Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. J Am Acad Dermatol 28:17\u201321","journal-title":"J Am Acad Dermatol"},{"key":"BF02505247_CR15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s001050050258","volume":"46","author":"RM Szeimies","year":"1995","unstructured":"Szeimies RM, Landthaler M (1995) Treatment of superficial skin tumours with topical photodynamic therapy. Hautarzt 46: 315\u2013318","journal-title":"Hautarzt"},{"key":"BF02505247_CR16","first-page":"1305","volume-title":"The metabolic basis of inherited diseases","author":"A Kappas","year":"1989","unstructured":"Kappas A, Sassa S, Galbrath RA, Nordmann Y (1989) The porphyrias. In: Scriver CR, Beaudet AL, Sly WS, Volle D (eds) The metabolic basis of inherited diseases, 6th edn. McGraw-Hill, New York, pp 1305\u20131365","edition":"6th edn"},{"key":"BF02505247_CR17","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/BF00371740","volume":"287","author":"A Martin","year":"1995","unstructured":"Martin A, Tope WD, Grevelink JM, Starr JC, Fewkes JL, Flotte TJ, Deutsch TF, Anderson RR (1995) Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic therapy. Arch Dermatol Res 287:665\u2013674","journal-title":"Arch Dermatol Res"},{"key":"BF02505247_CR18","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/bjc.1994.406","volume":"70","author":"C Abels","year":"1994","unstructured":"Abels C, Heil P, Dellian M, Kuhnle GEH, Baumgartner R, Goetz AE (1994) In vivo kinetics and spectra of 5-aminolevulinic acid induced fluorescence in an amelanotic melanoma of the hamster. Br J Cancer 70:826\u2013833","journal-title":"Br J Cancer"},{"key":"BF02505247_CR19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1751-1097.1994.tb05003.x","volume":"59","author":"RM Szeimies","year":"1994","unstructured":"Szeimies RM, Sassay T, Landthaler M (1994) Penetration potency of topical applied delta aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Photochem Photobiol 59:73\u201376","journal-title":"Photochem Photobiol"},{"key":"BF02505247_CR20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/abbi.1994.1158","volume":"310","author":"MHG Medeiros","year":"1994","unstructured":"Medeiros MHG, DiMascio P, Gr\u00fcndel S, Soboll S, Sies H, Bechara EJH (1994) Catabolism of 5-aminolevulinic acid to CO2 by rat liver mitochondria. Arch Biochem Biophys 310: 205\u2013209","journal-title":"Arch Biochem Biophys"},{"key":"BF02505247_CR21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0925-4439(94)90004-3","volume":"1225","author":"J Onuki","year":"1994","unstructured":"Onuki J, Medeiros MHG, Bechara EJH, DiMascio P (1994) 5-aminolevulinic acid induces single-strand breaks in plasmid pBR322 DNA in the presence of Fe2+ ions. Biochim Biophys Acta 1225:259\u2013263","journal-title":"Biochim Biophys Acta"},{"key":"BF02505247_CR22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0005-2728(05)80072-6","volume":"1056","author":"M Hermes-Lima","year":"1991","unstructured":"Hermes-Lima M, Medeiros MHG, Bechara EJH, DiMascio P (1991) Damage to rat liver mitochondria promoted by \u03b4-aminolevulinic acid-generated reactive oxygen species. Connections with acute intermittent porphyria and lead poisoning. Biochim Biophys Acta 1056:57\u201363","journal-title":"Biochim Biophys Acta"},{"key":"BF02505247_CR23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1117\/12.203452","volume":"2371","author":"C Fritsch","year":"1994","unstructured":"Fritsch C, Batz J, Bolsen K, Schulte KW, Ruzicka T, Goerz G (1994) Exogenous \u03b4-aminolevulinic acid induces the porphyrin biosynthesis in human skin organ cultures with different porphyrin patterns in normal and malignant human tissue. SPIE Proc 2371:215\u2013220","journal-title":"SPIE Proc"},{"key":"BF02505247_CR24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2340\/0001555574120123","volume":"74","author":"RM Szeimies","year":"1994","unstructured":"Szeimies RM, Hein R, B\u00e4umler W, Heine A, Landthaler M (1994) A possible new incoherent lamp for photodynamic treatment of superficial skin lesions. Acta Derm Venereol (Stockh) 74:117\u2013119","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"BF02505247_CR25","first-page":"99","volume":"9","author":"M Doss","year":"1971","unstructured":"Doss M, Schmidt A (1971) Quantitative Bestimmung der \u03b4-Aminol\u00e4vulins\u00e4ure und Porphobilinogen im Urin mit Ionenaustauscherchromatographie-Fertigs\u00e4ulen. Z Klin Chem Klin Biochem 9:99\u2013102","journal-title":"Z Klin Chem Klin Biochem"},{"key":"BF02505247_CR26","first-page":"415","volume":"9","author":"M Doss","year":"1971","unstructured":"Doss M, Schmidt A (1971) Rapid determination of urinary total porphyrins by ion exchange chromatography. Z Klin Chem Klin Biochem 9:415\u2013418","journal-title":"Z Klin Chem Klin Biochem"},{"key":"BF02505247_CR27","first-page":"932","volume":"81","author":"S Piomelli","year":"1973","unstructured":"Piomelli S, Young P, Gay G (1973) A micromethod for free erythrocyte porphyrins: the FEP test. J Lab Clin Med 81:932\u2013940","journal-title":"J Lab Clin Med"},{"key":"BF02505247_CR28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000459399","volume":"16","author":"M Doss","year":"1973","unstructured":"Doss M (1973) Metabolism of \u03b4-aminolevulinic acid and porphobilinogen in human erythrocytes in acute intermittent porphyria. Enzyme 16:343\u2013353","journal-title":"Enzyme"},{"key":"BF02505247_CR29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/gut.36.1.67","volume":"36","author":"J Regula","year":"1995","unstructured":"Regula J, MacRobert AJ, Gorchein A, Bonaccorsi GA, Thorpe SM, Spencer GM, Hatfield ARW, Bown SG (1995) Photosensitization and photodynamic therapy of esophageal, duodenal, and colorectal tumours using 5 aminolaevulinic acid induced protoporphyrin IX\u2014a pilot study. Gut 36:67\u201375","journal-title":"Gut"},{"key":"BF02505247_CR30","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1523-1747.ep12485121","volume":"68","author":"DR Bickers","year":"1977","unstructured":"Bickers DR, Keogh L, Rifkind AB, Harber LC, Kappas A (1977) Studies in porphyria. VI. Biosynthesis of porphyrins in mammalian skin and in the skin of porphyric patients. J Invest Dermatol 68:5\u20139","journal-title":"J Invest Dermatol"},{"key":"BF02505247_CR31","first-page":"891","volume":"70","author":"P Becker-Wegerich","year":"1995","unstructured":"Becker-Wegerich P, Fritsch C, Neuse W, Schulte KW, Ruzicka T, Goerz G (1995) Effektive Kryochirurgie oberfl\u00e4chlicher Hauttumoren unter photodynamischer Diagnostik. H+G 70:891\u2013895","journal-title":"H+G"},{"key":"BF02505247_CR32","first-page":"270","volume":"33","author":"M Kriegmair","year":"1994","unstructured":"Kriegmair M, Baumgartner R, Kn\u00fcchel R, Ehsan A, Steinbach P, Lumper W, Hofst\u00e4dter F, Hofstetter A (1994) Photodynamische Diagnose urothelialer Neoplasien nach intravesikaler Instillation von 5-Aminol\u00e4vulins\u00e4ure. Urologe 33:270\u2013275","journal-title":"Urologe"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02505247.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/BF02505247\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/BF02505247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:44:33Z","timestamp":1707295473000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/BF02505247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1996,8]]}},"alternative-id":["BF02505247"],"URL":"https:\/\/doi.org\/10.1007\/bf02505247","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,8]]}}}