{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:37:46Z","timestamp":1791063466810,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1Part1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to test the hypothesis that multiple antioxygenic nutrients provide increased protection against lipid peroxidative damage to rat liver. Rats were fed diets (i) deficient in vitamin E and selenium (Diet 1), (ii) supplemented with vitamin E and selenium (Diet 2), (iii) supplemented with (ii) and in addition trolox C,<jats:italic>N<\/jats:italic>\u2010acetylcysteine, coenzyme Q<jats:sub>0<\/jats:sub>, and (+)\u2010catechin (Diet 3), or (iv) supplemented with (iii) and in addition \u03b2\u2010carotene, ascorbic acid palmitate, canthaxanthin, and coenzyme Q<jats:sub>10<\/jats:sub> (Diet 4). Liver homogenates were obtained from three rats fed each of the diets for six weeks and were incubated at 37\u00b0C up to two hours with and without exogenous tertiary\u2010butyl hydroperoxide (TBHP) or Cu<jats:sup>2+<\/jats:sup>. Lipid peroxidation was determined by measurement of thiobarbituric acid substances. Diets 2 and 3 significantly protected against<jats:italic>in vivo<\/jats:italic> hepatic lipid peroxidation, and this protection was augmented by Diet 4. Diets 2, 3, and 4 were protective against mild oxidation induced by TBHP or Cu<jats:sup>2+<\/jats:sup>. During incubations with exogenous TBHP and Cu<jats:sup>2+<\/jats:sup>, there were only small differences between diets supplemented with antioxidants in inhibition of lipid peroxidation, indicating that diets supplemented with vitamin E and selenium (Diet 2) may have provided the maximal protection for liver. The possible mechanisms of protection provided by multiple antioxidants in diets were discussed. Protection by multiple antioxidants against lipid peroxidation may translate to prevention of peroxidative damage to human tissue, a factor in human disease.<\/jats:p>","DOI":"10.1007\/bf02522409","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T15:00:44Z","timestamp":1162479644000},"page":"47-50","source":"Crossref","is-referenced-by-count":29,"title":["Protection by multiple antioxidants against lipid peroxidation in rat liver homogenate"],"prefix":"10.1002","volume":"31","author":[{"given":"Hao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al","family":"Tappel","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology University of California 109 Food Science and Technology Building Davis CA 95616"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1996,1]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-4-526"},{"key":"e_1_2_2_3_1","first-page":"539","volume-title":"Lipid Damage and Repair: An Overview, in Oxidative Damage and Repair: Chemical, Biological and Medical Aspects","author":"Tappel A.L.","year":"1991"},{"key":"e_1_2_2_4_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/B978-0-08-041749-3.50016-4","volume-title":"Oxidative Damage and Repair: Chemical, Biological, and Medical Aspects","author":"Niki E.","year":"1991"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(89)90143-3"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(86)90461-2"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305203282004"},{"key":"e_1_2_2_8_1","first-page":"186","volume-title":"Third Conference of Vitamin C","author":"Niki E.","year":"1987"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/120.1.97"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(88)90066-3"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90120-1"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90258-9"},{"key":"e_1_2_2_13_1","first-page":"71","volume-title":"Vitamin E in Health and Disease","author":"Bor W.","year":"1993"},{"key":"e_1_2_2_14_1","first-page":"131","volume-title":"Biomedical and Clinical Aspects of Coenzyme Q.","author":"Kishi H.","year":"1984"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/119.4.665"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6710156"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(88)90499-6"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1974.tb06611.x"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02522409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:56:27Z","timestamp":1760968587000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/BF02522409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":17,"journal-issue":{"issue":"1Part1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1007\/BF02522409"],"URL":"https:\/\/doi.org\/10.1007\/bf02522409","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}