{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:54:50Z","timestamp":1761807290152,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1996,6,1]],"date-time":"1996-06-01T00:00:00Z","timestamp":833587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1996,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of fish oil high in docosahexaenoic acid (22\u22366n\u22123) and low in eicosapentaenoic acid (20\u22365n\u22123) in formula on blood lipids and growth of full\u2010term infants was studied. Infants were fed formula with about 15% oleic acid (18\u22361), 32% linoleic acid (18\u22362n\u22126), 4.9% linolenic acid (18\u22363n\u22123) and 0, 0.10 or 0.22% 22\u22366n\u22123, or 35% 18\u22361, 20% 18\u22362n\u22126, 2.1% 18\u22363n\u22123 and 0, 0.11 or 0.24% 22\u22366n\u22123 from 3 d to 16 wk of age (<jats:italic>n<\/jats:italic>=16, 18, 17, 21, 17, 16, respectively). The formulae had &lt;0.1% 20\u22365n\u22123 and no arachidonic acid (20\u22364n\u22126). Breast\u2010fed infants (<jats:italic>n<\/jats:italic>=26) were also studied. Plasma phospholipid and red blood cell (RBC) phosphatidylcholine (PC) and phosphatidylethanolamine (PE) fatty acids were determined at 3 d and 4, 8, and 16 wk of age. These longitudinal analyses showed differences in blood lipid 22\u22366n\u22123 between breast\u2010fed and formula\u2010fed infants depending on the feeding duration. At 16 wk, infants fed formula with 0.10, 0.11% 22\u22366n\u22123, or 0.22% 22\u22366n\u22123 had similar 22\u22366n\u22123 levels in the plasma phospholipid and RBC PC and PE compared with breast\u2010fed infants and higher 22\u22366n\u22123 than infants fed formula without 22\u22366n\u22123. Formula with 0.24% 22\u22366n\u22123, however, resulted in higher plasma phospholipid 22\u22366n\u22123 than in breast\u2010fed infants at 16, but not 4 or 8 wk of age. Plasma and RBC phospholipid 20\u22364n\u22126 was lower in formula\u2010fed than breast\u2010fed infants, but no differences in growth were found. Higher blood lipid C<jats:sub>20<\/jats:sub> and C<jats:sub>22<\/jats:sub> n\u22126 and n\u22123 fatty acids in infants fed formula with 20% 18\u22362n\u22126 and 2.4% 18\u22363n\u22123 compared with 32% 18\u22362n\u22126 and 4.9% 18\u22363n\u22123 show the increase in blood lipid 22\u22366n\u22123 in response to dietary 22\u22366n\u22123 depending on other fatty acids in the formula.<\/jats:p>","DOI":"10.1007\/bf02523832","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:43:50Z","timestamp":1162860230000},"page":"617-625","source":"Crossref","is-referenced-by-count":56,"title":["Blood lipid docosahexaenoic and arachidonic acid in term gestation infants fed formulas with high docosahexaenoic acid, low eicosapentaenoic acid fish oil"],"prefix":"10.1002","volume":"31","author":[{"given":"Sheila M.","family":"Innis","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of British Columbia Vancouver British Columbia V5Z 4H4 Canada"},{"name":"B.C. Research Institute for Child and Family Health 950 West 28th Ave. Vancouver B.C. V5Z 4H4 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Auestad","sequence":"additional","affiliation":[{"name":"Ross Products Division Abbott Laboratories Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel S.","family":"Siegman","sequence":"additional","affiliation":[{"name":"Ross Products Division Abbott Laboratories Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,6]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(91)90006-Q"},{"key":"e_1_2_2_3_1","first-page":"18","volume-title":"Essential Fatty Acids and Eicosanoids","author":"Sprecher H.","year":"1993"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(92)90198-5"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81237-5"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.3.347"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199212000-00012"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/36.1.106"},{"key":"e_1_2_2_9_1","first-page":"425","article-title":"Erythrocyte Docosahexaenoic Acid Correlates with the Visual Response of Healthy, Term Infants","volume":"34","author":"Makrides M.","year":"1993","journal-title":"Pediatr. Res."},{"key":"e_1_2_2_10_1","first-page":"302A","article-title":"Visual Acuity, RBC Fatty Acids and Growth in Term Infants Fed Formulas With and Without Long\u2010Chain Polyunsaturated Fatty Acid (LCP)","volume":"37","author":"Auestad N.","year":"1995","journal-title":"Ped. Res."},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535868"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199111000-00003"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535870"},{"key":"e_1_2_2_14_1","first-page":"192","volume-title":"Essential Fatty Acids and Eicosanoids","author":"Carlson S.E.","year":"1993"},{"key":"e_1_2_2_15_1","first-page":"310A","article-title":"Fatty Acids Affect Early Language Development","volume":"37","author":"Janowsky J.S.","year":"1995","journal-title":"Ped. Res."},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91035-2"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/119.12.1880"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111202"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.11.4021"},{"key":"e_1_2_2_20_1","unstructured":"Innis S.M. Nelson C.M. Rioux F.M. Lwang D. andWaslen P. Feeding Formula Without Arachidonic Acid and Docosahexaenoic Acid Has No Effect on Preferential Looking Acuity or Recognition Memory in Healthy Term Infant Am. J. Clin. Nutr. in press."},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02522418"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/124.2.289"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536625"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(91)90254-F"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.1073"},{"key":"e_1_2_2_26_1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1542\/peds.89.6.1035","article-title":"Growth of Breast\u2010Fed and Formula\u2010Fed Infants from Birth to 18 Months: The Darling Study","volume":"89","author":"Dewey K.G.","year":"1992","journal-title":"Pediatrics"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02535583"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536121"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02523832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:49:02Z","timestamp":1760953742000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/BF02523832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,6]]}},"alternative-id":["10.1007\/BF02523832"],"URL":"https:\/\/doi.org\/10.1007\/bf02523832","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"type":"print","value":"0024-4201"},{"type":"electronic","value":"1558-9307"}],"subject":[],"published":{"date-parts":[[1996,6]]}}}