{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:35:18Z","timestamp":1760920518802,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1977,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Food and Drug Administration policy being considered for new marketed hypolipidemic agents includes: long\u2010term safety to be demonstrated in postmarketing studies; evidence of clinical effectiveness to be demonstrated within a specified time period. Effectiveness is to be judged by one or more of the following: reduction in xanthomata, reduction in atherosclerotic plaque, reduction in morbidity of coronary artery disease or peripheral and cerebral atherosclerosis, and reduction in mortality. Randomized double blind trials are deemed necessary.<\/jats:p>","DOI":"10.1007\/bf02532974","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T01:49:12Z","timestamp":1164160152000},"page":"64-65","source":"Crossref","is-referenced-by-count":6,"title":["FDA considerations regarding new hypolipidemic agents"],"prefix":"10.1002","volume":"12","author":[{"given":"Marion J.","family":"Finkel","sequence":"first","affiliation":[{"name":"New Drug Evaluation Bureau of Drugs, Food and Drug Administration 5600 Fishers Lane Rockville MD 20852"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,1]]},"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02532974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:11:08Z","timestamp":1760875868000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/BF02532974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["10.1007\/BF02532974"],"URL":"https:\/\/doi.org\/10.1007\/bf02532974","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"type":"print","value":"0024-4201"},{"type":"electronic","value":"1558-9307"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}