{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:38:00Z","timestamp":1760920680532,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1967,11,1]],"date-time":"1967-11-01T00:00:00Z","timestamp":-68428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1967,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The metabolism of 1\u2010<jats:sup>14<\/jats:sup>C arachidonate was studied in pyridoxine\u2010deficient and pair\u2010fed pyridoxine\u2010supplemented control rats. The studies included intestinal absorption, oxidation to<jats:sup>14<\/jats:sup>CO<jats:sub>2<\/jats:sub>, organ uptakes and distribution of<jats:sup>14<\/jats:sup>C in the fatty acids of the various organs. Generally, pyridoxine deficiency resulted in little or no alteration of the metabolism of arachidonic acid 6 and 12 hrs after oral administration. A notable exception occurred in hearts of deficient animals in which the proportion of the incorporated<jats:sup>14<\/jats:sup>C activity found in fatty acids other than 20:4 was larger than that observed in hearts of pyridoxine\u2010supplemented animals. A significant amount of<jats:sup>14<\/jats:sup>C activity in a water\u2010soluble form was observed in hydrolysates of intestinal contents and of intestines of both groups. Pyridoxine\u2010deficient rats had larger quantities than their respective pair\u2010fed pyridoxine\u2010supplemented controls. Most of the<jats:sup>14<\/jats:sup>C activity of fatty acids of various organs was present as arachidonic acid, but significant activity was present both in fatty acids of shorter and of longer retention time than 20:4. In brain about 20% of the<jats:sup>14<\/jats:sup>C activity in fatty acids was in a fraction tentatively identified as an 18:2 isomer. In lungs about 10% of the<jats:sup>14<\/jats:sup>C activity was in a fraction tentatively identified as a 22:2 isomer and a similar quantity was observed in a polyene tentatively identified as a 22:4.<\/jats:p>","DOI":"10.1007\/bf02533176","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T00:45:29Z","timestamp":1164156329000},"page":"484-488","source":"Crossref","is-referenced-by-count":7,"title":["The metabolism of 1\u2010<sup>14<\/sup>C arachidonic acid in pyridoxine\u2010deficient and pair\u2010fed control rats"],"prefix":"10.1002","volume":"2","author":[{"given":"J. G.","family":"Coniglio","sequence":"first","affiliation":[{"name":"Department of Biochemistry Vanderbilt University, School of Medicine Nashville Tennessee"},{"name":"Department of Chemistry Medical College of South Carolina Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. B.","family":"Culp","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Vanderbilt University, School of Medicine Nashville Tennessee"},{"name":"Department of Biochemistry University of Georgia Athens Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Vanderbilt University, School of Medicine Nashville Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1967,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1016\/S0083-6729(08)60364-7"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1016\/0003-9861(52)90455-4"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_1","DOI":"10.1016\/S0021-9258(18)64056-6"},{"key":"e_1_2_1_5_1","first-page":"311","volume":"233","author":"Hirsch J.","year":"1958","journal-title":"Ibid."},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_1","DOI":"10.1021\/ac60171a016"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_1","DOI":"10.1093\/jn\/89.2.210"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_1","DOI":"10.1016\/S0022-2275(20)38975-6"},{"issue":"8","key":"e_1_2_1_9_1","first-page":"1","volume":"17","author":"Farquhar J. 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