{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:35:48Z","timestamp":1760920548414,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[1978,11,1]],"date-time":"1978-11-01T00:00:00Z","timestamp":278726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1978,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanism and characteristics of intestinal absorption of arachidonic acid were studied in vitro using everted intestinal sacs of the rat. Arachidonic acid absorption was studied at concentrations of 5 \u03bcM to 8.36 mM. The plot of absorption rate vs. concentration fitted best to a rectangular hyperbola at low \u03bcM concentrations and to a straight linear relationship in the mM range of concentrations. Metabolic inhibitors and uncouplers did not change absorption in either range of concentrations. The absorption of arachidonic acid increased with thinning of the unstirred water\u2010layer, decrease in the pH, or the substitution of sodium taurocholate by Pluronic F 68 or Tween 80. Absorption decreased following the equimolar additions of oleic, linoleic, and linolenic acids. Absorption rate did not change when the taurocholate concentration was varied from 5\u201315 mM or following the additions of butyric or glutamic acids, leucine, lysine, or dextrose. It was concluded that arachidonic acid is absorbed by a concentration\u2010dependent dual mechanism of transport which is not energy dependent. At the low \u03bcM range of concentrations, facilitated diffusion is predominant, while at mM concentrations, simple diffusion is the dominant mechanism of absorption. Changes in the intestinal fluid composition, flow rate, and pH can modify the rate of absorption of arachidonic acid.<\/jats:p>","DOI":"10.1007\/bf02533474","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T03:11:57Z","timestamp":1164165117000},"page":"768-776","source":"Crossref","is-referenced-by-count":18,"title":["Arachidonic acid intestinal absorption: Mechanism of transport and influence of luminal factors on absorption in vitro"],"prefix":"10.1002","volume":"13","author":[{"given":"San Laung","family":"Chow","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Wayne State University and Harper\u2010Grace Hospitals Detroit Michigan 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Hollander","sequence":"additional","affiliation":[{"name":"Department of Medicine Long Beach VA Hospital 5901 E. 7th Street Long Beach CA 90822"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1978,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)97174-7"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(64)90145-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(64)90144-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/203839a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(65)90153-0"},{"key":"e_1_2_1_7_1","first-page":"629","volume":"44","author":"McDonald P.C.","year":"1974","journal-title":"Obst. Gynecol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)93034-2"},{"key":"e_1_2_1_9_1","first-page":"387","volume":"19","author":"Bieck P.R.","year":"1971","journal-title":"Clin. Res."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.18.6.429"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1974.226.1.50"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39276-2"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1973.225.2.360"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(75)80137-5"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1976.231.2.415"},{"key":"e_1_2_1_16_1","first-page":"E471","volume":"232","author":"Hollander D.","year":"1977","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_17_1","first-page":"1","volume-title":"Applied Regression Analysis","author":"Draper N.R.","year":"1966"},{"key":"e_1_2_1_18_1","first-page":"150","volume-title":"Introduction to Statistical Analysis","author":"Dixon W.J.","year":"1969"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(75)80237-X"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/107.3.353"},{"key":"e_1_2_1_21_1","first-page":"885","volume":"19","author":"Herbert V.","year":"1960","journal-title":"Fed. Proc."},{"key":"e_1_2_1_22_1","first-page":"57a","volume":"53","author":"Ockner R.K.","year":"1974","journal-title":"J. Clin. Invest."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4043.56"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107768"},{"key":"e_1_2_1_25_1","first-page":"1245","volume-title":"Handbook of Physiology","author":"Schultz S.G.","year":"1968"},{"key":"e_1_2_1_26_1","first-page":"69","volume-title":"Gastrointestinal Physiology","author":"Schultz S.G.","year":"1974"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1972.03650040040005"},{"key":"e_1_2_1_28_1","first-page":"144","volume-title":"Colloid Science","author":"Kruyt H.R.","year":"1952"},{"key":"e_1_2_1_29_1","first-page":"103","volume-title":"The Bile Acids","author":"Hofmann A.F.","year":"1973"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1958.sp005955"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1975.sp011060"},{"key":"e_1_2_1_32_1","first-page":"89","volume":"37","author":"Dietschy J.M.","year":"1973","journal-title":"Helv. Med. Acta"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4013.1031"},{"key":"e_1_2_1_34_1","first-page":"298","volume-title":"Transport Mechanisms in Epithelia","author":"Curran P.F.","year":"1972"},{"key":"e_1_2_1_35_1","first-page":"77","volume-title":"Intestinal Absorption and Malabsorption","author":"Schultz S.G.","year":"1975"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02533474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:12:57Z","timestamp":1760875977000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/BF02533474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1978,11]]}},"alternative-id":["10.1007\/BF02533474"],"URL":"https:\/\/doi.org\/10.1007\/bf02533474","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"type":"print","value":"0024-4201"},{"type":"electronic","value":"1558-9307"}],"subject":[],"published":{"date-parts":[[1978,11]]}}}