{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:31:41Z","timestamp":1760920301605,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1978,6,1]],"date-time":"1978-06-01T00:00:00Z","timestamp":265507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1978,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rats of the Lewis strain were fed diets adequate or deficient in essential fatty acids (EFA). At 70\u201380 days of age experimental allergic encephalomyelitis (EAE) was induced using adjuvants containing either<jats:italic>Mycobacterium butyricum<\/jats:italic> or<jats:italic>Mycobacterium tuberculosis H37Ra<\/jats:italic>. When the former<jats:italic>Mycobacterium<\/jats:italic> was used, the incidence of EAE was greater in the EFA\u2010deficient than in EFA\u2010adequate controls; but when the rats challenged with<jats:italic>M. tuberculosis<\/jats:italic>, the incidence of the disease was the same in both dietary groups. Brain slices from EFA\u2010deficient rats had a marginally depressed synthesis of prostaglandin F (PGF) compared to that of controls. Immunochallenge with adjuvant alone or adjuvant plus antigen tended to depress further PGF synthesis by brain slices from EFA\u2010deficient rats and significantly depressed synthesis by slices from rats receiving adequate EFA. Whether or not rats were paralyzed had no effect on PGF synthesis when the diet was adequate in EFA, but a significant difference was seen in the EFA\u2010deficient group. The results indicate a possible role for PGF synthesis in the degree of susceptibility of the rats to EAE under different dietary regimens.<\/jats:p>","DOI":"10.1007\/bf02533710","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T03:09:41Z","timestamp":1164164981000},"page":"408-414","source":"Crossref","is-referenced-by-count":23,"title":["Cerebral prostaglandin synthesis during the dietary and pathological stresses of essential fatty acid deficiency and experimental allergic encephalomyelitis"],"prefix":"10.1002","volume":"13","author":[{"given":"Patricia G.","family":"Weston","sequence":"first","affiliation":[{"name":"Department of Food Science, Burnsides Research Laboratory University of Illinois at Urbana\u2010Champaign Urbana Illinois 61801"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia V.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Food Science, Burnsides Research Laboratory University of Illinois at Urbana\u2010Champaign Urbana Illinois 61801"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1978,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1967.tb05740.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/105.3.288"},{"key":"e_1_2_1_4_1","first-page":"175","volume-title":"Prostaglandin Synthetase Inhibitors","author":"Ferreira S.H.","year":"1974"},{"key":"e_1_2_1_5_1","first-page":"791","volume":"2","author":"Vane J.R.","year":"1976","journal-title":"Adv. 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