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Serum samples collected on the 21st day of the menstrual cycle were analyzed for cholesterol in lipoprotein fractions, isolated by a combination of precipitation and ultracentrifugation techniques. Eighty\u2010five percent of patients showed objective and subjective remission from disease following therapy. In mammary dysplasia patients, the ratio of serum cholesterol\/high density lipoprotein cholesterol was higher than those in age\u2010matched controls, an abnormality which was corrected by \u03b1\u2010tocopherol therapy. Furthermore, as a result of therapy, high density lipoproteins increased and ester cholesterol associated with low density lipoproteins decreased. The results suggest that \u03b1\u2010tocopherol may serve as an effective agent in treating patients with benign breast disease, as well as correct the inherent abnormality in serum cholesterol distribution in mammary dysplasia patients.<\/jats:p>","DOI":"10.1007\/bf02535020","type":"journal-article","created":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T02:04:34Z","timestamp":1165284274000},"page":"223-227","source":"Crossref","is-referenced-by-count":22,"title":["\u03b1\u2010Tocopherol and serum lipoproteins"],"prefix":"10.1002","volume":"16","author":[{"given":"G. S.","family":"Sundaram","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology Sinai Hospital of Baltimore, Inc. 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