{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:34:53Z","timestamp":1760981693670,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[1989,7,1]],"date-time":"1989-07-01T00:00:00Z","timestamp":615254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Weanling male spontaneously hypertensive (SHR) and normotensive (WKY) rats were maintained on a fat\u2010free semisynthetic diet and killed at various intervals. The effects of fat\u2010depletion on the appearance of essential fatty acid (EFA) deficiency symptoms, the progressive changes of major fatty acids in plasma, liver, heart, and kidney phospholipids (PL), and in skin total lipids were compared between these two strains. After five weeks on the diet, the slower growth and the appearance of EFA deficiency symptoms became evident in SHR. In general, fat\u2010depletion reduced the levels of n\u22126 fatty acids, whereas it increased those of 20\u22363n\u22129. However, the fat\u2010depletion induced reduction of 18\u22362n\u22126 in heart PL and 20\u22364n\u22126 in kidney, while the elevation of 20\u22363n\u22129 in plasma, heart, and kidney PL were greater in WKY than in SHR. As a result, the elevation of biochemical EFA deficiency index\u201420\u22363n\u22129\/20\u22364n\u22126 ratio\u2014was greater in WKY than in SHR. In comparison with WKY, the concentrations of liver triacylglycerols and the weights of adipose tissues in SHR were reduced to a greater extent, indicating an active catabolism of triacylglycerols in SHR. This study suggests that the earlier appearance of morphological symptoms of EFA deficiency in SHR was not associated with the reducing n\u22126 EFA levels or with an elevation of triene\/tetraene ratio, but possibly to a reduced supply of n\u22126 EFA for skin prostaglandin synthesis.<\/jats:p>","DOI":"10.1007\/bf02535070","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T04:22:33Z","timestamp":1164774153000},"page":"565-571","source":"Crossref","is-referenced-by-count":9,"title":["Effect of essential fatty acid depletion on tissue phospholipid fatty acids in spontaneously hypertensive and normotensive rats"],"prefix":"10.1002","volume":"24","author":[{"given":"Yung\u2010Sheng","family":"Huang","sequence":"first","affiliation":[{"name":"Efamol Research Institute Kentville Nova Scotia B4N 4H8 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave E.","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Health Studies University of Waterloo Waterloo Ontario N2L 3G1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron P.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Health Studies University of Waterloo Waterloo Ontario N2L 3G1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Horrobin","sequence":"additional","affiliation":[{"name":"Efamol Research Institute Kentville Nova Scotia B4N 4H8 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie A.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Efamol Research Institute Kentville Nova Scotia B4N 4H8 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,7]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.27.282"},{"key":"e_1_2_2_3_1","first-page":"227","volume":"7","author":"Okamoto K.","year":"1969","journal-title":"Int. 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