{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:44:01Z","timestamp":1791287041367,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1989,8,1]],"date-time":"1989-08-01T00:00:00Z","timestamp":617932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1989,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experimental Mg<jats:sup>2+<\/jats:sup> deficiency was induced in a group of rats by feeding them a Mg<jats:sup>2+<\/jats:sup>\u2010deficient diet for 23 days. They were pair\u2010fed to compare with a control group of rats fed a Mg<jats:sup>2+<\/jats:sup>\u2010sufficient diet. In the Mg<jats:sup>2+<\/jats:sup>\u2010deficient group the plasma total cholesterol and triglyceride levels were increased while HDL\u2010cholesterol was decreased. In the Mg<jats:sup>2+<\/jats:sup>\u2010deficient group the plasma level of thiobarbituric acid reacting substances (TBARS) used as a measure for lipid peroxidation was increased. The increase was attributed to the increased cytosolic Ca<jats:sup>2+<\/jats:sup> in Mg<jats:sup>2+<\/jats:sup>\u2010deficiency which can cause: 1) increase of hydro and endoperoxide levels as a consequence of the increase of arachidonic acid release and eicosanoid synthesis in Mg<jats:sup>2+<\/jats:sup>\u2010deficiency, and 2) inhibition of the mitochondrial respiratory activity and activation of Ca<jats:sup>2+<\/jats:sup>\u2010dependent proteases which may activate the conversion of xanthine dehydrogenase to xanthine oxidase which generates active O<jats:sub>2<\/jats:sub> species. In the Mg<jats:sup>2+<\/jats:sup>\u2010deficient group, the fatty acid composition of the liver microsomes indicated a slower rate of conversion of linoleic acid to arachidonic acid which was consistent with the decrease of \u03946 desaturase activity in liver microsomes of Mg<jats:sup>2+<\/jats:sup>\u2010deficient rats as measured<jats:italic>in vitro<\/jats:italic>. The decrease of \u03946 desaturase activity was attributed to the lower concentration of actual enzyme molecules as a result of the decreased rate of protein synthesis in Mg<jats:sup>2+<\/jats:sup>\u2010deficiency. The possible effects of the increased catecholamine release in Mg<jats:sup>2+<\/jats:sup>\u2010deficiency are discussed.<\/jats:p>","DOI":"10.1007\/bf02535212","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T04:42:18Z","timestamp":1164775338000},"page":"727-732","source":"Crossref","is-referenced-by-count":59,"title":["Effect of magnesium deficiency on \u03946 desaturase activity and fatty acid composition of rat liver microsomes"],"prefix":"10.1002","volume":"24","author":[{"given":"M. M.","family":"Mahfouz","sequence":"first","affiliation":[{"name":"Burnsides Research Laboratory University of Illinois 1208 W. Pennsylvania Ave. Urbana Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. A.","family":"Kummerow","sequence":"additional","affiliation":[{"name":"Burnsides Research Laboratory University of Illinois 1208 W. 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