{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:48:44Z","timestamp":1766400524478,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1989,2,1]],"date-time":"1989-02-01T00:00:00Z","timestamp":602294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Because copper and iron have been reported to be essential cofactors in \u03949 desaturation of fatty acids, the effects of different dietary intakes of copper and iron on tissue fatty acids were studied. Male Long\u2010Evans rats (ten per group) were fed diets containing adequate, deficient or excess copper or iron. On day 42 of the dietary regimen, the animals were killed and tissues and blood were removed for analysis of metals and fatty acids of phospholipids. Compared with the copper\u2010adequate rats, the copper\u2010deficient rats showed increased 18\u22360 in liver and decreased 16\u22361\u03c97 in liver, heart and serum. There were no differences for 16\u22360 or 18\u22361\u03c99. Intake of excess copper did not cause an increase in products of \u03949 desaturation. Comparisons between iron\u2010deficient and iron\u2010adequate rats showed that iron deficiency increased 18\u22362\u03c96 in liver and serum and decreased 20\u22364\u03c96 in serum only. Relative percentages of 16\u22360, 18\u22360, 16\u22361\u03c97 and 18\u22361\u03c99 in liver and serum phospholipids were similar for both groups. Intake of excess iron caused a decrease in 18\u22362\u03c96; and 16\u22360 and 18\u22361\u03c99 were higher in the liver of the iron\u2010excess group than the iron\u2010deficient group. This study did not support the requirement for copper or iron in the \u03949 desaturation of fatty acids as expressed in phospholipids of liver, heart and serum.<\/jats:p>","DOI":"10.1007\/bf02535252","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T02:39:36Z","timestamp":1164767976000},"page":"141-145","source":"Crossref","is-referenced-by-count":21,"title":["Fatty acid pattern of tissue phospholipids in copper and iron deficiencies"],"prefix":"10.1002","volume":"24","author":[{"given":"Susan B.","family":"Johnson","sequence":"first","affiliation":[{"name":"Grand Forks Human Nutrition Research Center, Agriculture Research Service United States Department of Agriculture Grand Forks ND 58202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim R.","family":"Kramer","sequence":"additional","affiliation":[{"name":"the Hormel Institute University of Minnesota 801 16th Avenue NE Austin MN 55912"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Briske\u2010Anderson","sequence":"additional","affiliation":[{"name":"the Hormel Institute University of Minnesota 801 16th Avenue NE Austin MN 55912"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph T.","family":"Holman","sequence":"additional","affiliation":[{"name":"Grand Forks Human Nutrition Research Center, Agriculture Research Service United States Department of Agriculture Grand Forks ND 58202"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,2]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(81)90112-0"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19830036"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas1973.365868x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000176967"},{"key":"e_1_2_2_6_1","first-page":"1062","volume":"23","author":"Holman R.T.","year":"1964","journal-title":"Fed. 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