{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:09:54Z","timestamp":1791925794869,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1988,5,1]],"date-time":"1988-05-01T00:00:00Z","timestamp":578448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The principal objective of this investigation was to examine the \u03c9\u2010hydroxyacid derivatives in the cornified layer of human skin. Toward this end, sunburn peelings were collected, and the lipids were extracted with chlofoform\/methanol. Comparison with authentic standards by thin layer chromatography (TLC) indicated the presence of both N\u2010(\u03c9\u2010acyloxy)acylsphingosine (acylceramide) and \u03c9\u2010acyloxy fatty acid (acyl acid), which accounted for 1.7% and 2.0% of the total lipid, respectively, as estimated by photodensitometry of the charred chromatograms. Each of these lipids was isolated by preparative TLC, hydrolyzed, and the resulting fragments were further analyzed by TLC and by gas liquid chromatography (GLC) of appropriate derivatives. In both of these lipids, the predominant \u03c9\u2010hydroxyacid proved to be the 30\u2010carbon saturated species (56\u201359% of the total), while linoleate was the major ester\u2010linked fatty acid. Linoleate was more abundant in the acyl acid (38.0%) than in acylceramide (21.4%). These findings represent the first demonstration of acyl acid in human skin and support the proposition that acyl acid, like the other linoleate\u2010rich \u03c9\u2010hydroxyacid derivatives, functions as a molecular rivet in maintaining epidermal structure and fucntion.<\/jats:p>","DOI":"10.1007\/bf02535512","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T01:29:15Z","timestamp":1164763755000},"page":"415-418","source":"Crossref","is-referenced-by-count":11,"title":["Hydroxyacid derivatives in human epidermis"],"prefix":"10.1002","volume":"23","author":[{"given":"Philip W.","family":"Wertz","sequence":"first","affiliation":[{"name":"Marshall Dermatology Research Laboratories, 270 Medical Laboratories, Department of Dermatology University of Iowa College of Medicine Iowa City IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald T.","family":"Downing","sequence":"additional","affiliation":[{"name":"Marshall Dermatology Research Laboratories, 270 Medical Laboratories, Department of Dermatology University of Iowa College of Medicine Iowa City IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1988,5]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)78929-5"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb15424.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12541775"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7112128"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(78)90058-9"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37949-9"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)34334-0"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37950-5"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(85)90016-5"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00509081"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12471781"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(85)90017-7"},{"key":"e_1_2_2_14_1","first-page":"429","volume":"75","author":"Colton S.W.","year":"1983","journal-title":"Comp. 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Physiol."},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02540132"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39090-8"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(68)85011-3"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12263553"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12512473"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12695343"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(73)90076-2"}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02535512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:31:18Z","timestamp":1760884278000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/BF02535512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,5]]}},"alternative-id":["10.1007\/BF02535512"],"URL":"https:\/\/doi.org\/10.1007\/bf02535512","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"value":"0024-4201","type":"print"},{"value":"1558-9307","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}