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Concomitantly, incorporation into cholesteryl esters was strongly inhibited (20% of control for 5.10<jats:sup>\u22125<\/jats:sup> M trifluoperazine). The drug did not change the phospholipid composition of treated cells. The effect of trifluoperazine on oleic acid incorporation into phospholipids was time\u2010dependent and reached a maximum after a six\u2010hr preincubation with the drug. Trifluoperazine also induced an increase in the rate of chase of oleic acid from the different phospholipid classes. In vitro preincubation of cell\u2010free extracts with trifluoperazine resulted in activation of phospholipid acyltransferases, whereas cholesterol acyltransferase activity was decreased. The rapid effect of trifluoperazine together with its effect on a cell\u2010free system suggests a direct action of this amphiphilic drug on the acyltransferase activities, probably by modification of the structural organization of cellular membranes.<\/jats:p>","DOI":"10.1007\/bf02535513","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T01:29:15Z","timestamp":1164763755000},"page":"419-423","source":"Crossref","is-referenced-by-count":18,"title":["Trifluoperazine increases fatty acid turnover in phospholipids in cultured human fibroblasts"],"prefix":"10.1002","volume":"23","author":[{"given":"Cecile","family":"Mazi\u00e8re","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie Biologique and U.A. 524 Facult\u00e9 de Medecine Saint Antoine 27 rue Chaligny Paris 75012 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Claude","family":"Mazi\u00e8re","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Biologique and U.A. 524 Facult\u00e9 de Medecine Saint Antoine 27 rue Chaligny Paris 75012 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Mora","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Biologique and U.A. 524 Facult\u00e9 de Medecine Saint Antoine 27 rue Chaligny Paris 75012 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Auclair","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Biologique and U.A. 524 Facult\u00e9 de Medecine Saint Antoine 27 rue Chaligny Paris 75012 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Polonovski","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie Biologique and U.A. 524 Facult\u00e9 de Medecine Saint Antoine 27 rue Chaligny Paris 75012 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1988,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0026-895X(25)12432-2","volume":"13","author":"Levin R.M.","year":"1977","journal-title":"Mol. 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