{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:44:11Z","timestamp":1760921051669,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[1987,11,1]],"date-time":"1987-11-01T00:00:00Z","timestamp":562723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alkyl lysophospholipids (ALP) are synthetic analogues of lysophosphatidylcholine and represent a new generation of antitumor drugs currently being tested in phase\u2010I trials in patients with cancer. The present study reports the differential modulation of human immunocompetent cells in vitro by ALP. Serum\u2010bound ALP effectively blocked the response of growth factor\u2010dependent cells to interleukin\u20102 (IL\u20102), inhibited the cellular production and release of IL\u20102 and suppressed the comitogenic effect of interleukin\u20101 (IL\u20101) on mouse thymocytes. In contrast, ALP\u2010primed, monocyte\u2010derived macrophages (MO) lost their ability to release IL\u20101 in response to stimuli like lipopolysaccharides (LPS) during terminal maturation from monocytes. Supernatants from ALP\u2010primed, LPS\u2010induced MO possessed costimulatory as well as direct mitogenic activity. Neither ALP alone nor ALP\u2010conditioned MO supernatants stimulated mouse thymocytes. Priming of MO by ET\u201018\u2010OH, an ALP molecule not substituted in the<jats:italic>sn<\/jats:italic>\u20102 position, occurred at concentrations 4\u2010 to 16\u2010fold higher than the most active compounds ET\u201018\u2010OCH, and the thioether analogue BM 41.440. ALP also primed MO for subsequent activation of tumor cytotoxicity by LPS and interferon\u2010gamma.<\/jats:p><jats:p>IL\u20101 has multiple biological activities in common with ALP, and it may mediate antitumor activity and other ALP effects in vivo. The ability of ALP to induce differential immunomodulation, as demonstrated in this study, may make ALP worthy of study for the therapy of both autoimmune and neoplastic disease.<\/jats:p>","DOI":"10.1007\/bf02535540","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T10:25:40Z","timestamp":1164968740000},"page":"836-841","source":"Crossref","is-referenced-by-count":20,"title":["Differential effects of ether lipids on the activity and secretion of interleukin\u20101 and interleukin\u20102"],"prefix":"10.1002","volume":"22","author":[{"given":"Reinhard","family":"Andreesen","sequence":"first","affiliation":[{"name":"Medizinische Klinik I der Universit\u00e4t Freiburg i. 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