{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:35:10Z","timestamp":1760981710060,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[1987,11,1]],"date-time":"1987-11-01T00:00:00Z","timestamp":562723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This review covers the work of our laboratory on the antineoplastic activity of some ethei lipids and derivatives that are related to platelet\u2010activating factor (PAF). Various 1\u2010<jats:italic>O<\/jats:italic>\u2010alkyl lysophospholipid derivatives (ALP) show therapeutic activity in mouse transplant tumor models and in metastatic 3\u2010Lewis lung carcinoma in vivo. However, certain autochthonous mouse leukemias and radiation\u2010induced lymphomas are resistant to ALP treatment. The therapeutic effects of these compounds are partially due to the activation of cytotoxic macrophages and direct cytotoxicity.<\/jats:p><jats:p>Approximately 20 ether lipids and derivatives were tested for direct cytotoxicity in cells from human solid tumors and leukemias using [<jats:sup>3<\/jats:sup>H]thymidine uptake, trypan blue dye exclusion, human tumor clonogenic assays (HTCA) and cell morphology as criteria. Certain ALP, thioether lysophospholipid\u2010derivatives (TLP), ether0linked lipoidal amines,<jats:italic>sn\u20102<\/jats:italic> analogs of PAF, and conjugates of ether lipids and cytosine arabinoside were found cytotoxic in a dose\u2010 and time\u2010dependent fashion. Cytotoxicity of some of the ether lipids tested is based on destruction of cell membranes. Structure\u2010activity studies were performed to better understand the mechanisms leading to accumulation and cytotoxicity of ALP. Comparative studies with normal bone marrow cells and leukemic blasts from humans revealed preferential antileukemic cytotoxity of three ether lipids.<\/jats:p>","DOI":"10.1007\/bf02535567","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T10:25:40Z","timestamp":1164968740000},"page":"970-973","source":"Crossref","is-referenced-by-count":16,"title":["Ether lipids and analogs in experimental cancer therapy. A brief review of the munich experience"],"prefix":"10.1002","volume":"22","author":[{"given":"Wolfgang E.","family":"Berdel","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine I Technische Universitaet Ismaninger Str. 22 Munich 80 8000 Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1987,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"411","volume-title":"VIIth International Symposium of Immunopathology, Bad Schachen, Germany, 1976","author":"Munder P.G.","year":"1977"},{"key":"e_1_2_1_3_1","first-page":"125","volume":"32","author":"Ando K.","year":"1972","journal-title":"Cancer Res."},{"key":"e_1_2_1_4_1","first-page":"221","volume":"52","author":"Boeryd B.","year":"1971","journal-title":"Br. J. Exp. Pathol."},{"key":"e_1_2_1_5_1","first-page":"24","volume-title":"Fifth Meeting","author":"Berdel W.E.","year":"1979"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(80)90179-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(83)90051-4"},{"key":"e_1_2_1_8_1","first-page":"41","volume-title":"Phospholipids and Cellular Regulation","author":"Berdel W.E.","year":"1985"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536417"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(82)80064-8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821115)50:10<2011::AID-CNCR2820501006>3.0.CO;2-K"},{"key":"e_1_2_1_12_1","first-page":"3211","volume":"41","author":"Honma Y.","year":"1981","journal-title":"Cancer Res."},{"key":"e_1_2_1_13_1","first-page":"351","volume":"45","author":"Storme G.A.","year":"1985","journal-title":"Cancer Res."}],"container-title":["Lipids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/BF02535567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:09:35Z","timestamp":1760882975000},"score":1,"resource":{"primary":{"URL":"https:\/\/aocs.onlinelibrary.wiley.com\/doi\/10.1007\/BF02535567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1987,11]]}},"alternative-id":["10.1007\/BF02535567"],"URL":"https:\/\/doi.org\/10.1007\/bf02535567","archive":["Portico"],"relation":{},"ISSN":["0024-4201","1558-9307"],"issn-type":[{"type":"print","value":"0024-4201"},{"type":"electronic","value":"1558-9307"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}