{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:59Z","timestamp":1761006959439,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To test for a regulatory defect in adipose triacylglycerol (essential) fatty acid mobilization in lymphoma\u2010bearing mice, free [1\u2010<jats:sup>14<\/jats:sup>C]linoleic acid\/mouse serum albumin was injected<jats:italic>iv<\/jats:italic> into lymphoma\u2010bearing and control mice, adapted to a reversed light cycle, and studied in three dietary states in the dark period. Mean daily food intake decreased in mice with small and large tumor burdens. Plasma free fatty acid (FFA) oxidation rates, which approximate FFA mobilization rates, were estimated by multicompartmental analysis (CONSAM). Oxidation of linoleate to CO<jats:sub>2<\/jats:sub> was reduced significantly (85%) in<jats:italic>ad libitum<\/jats:italic> fed as compared to briefly fasted control mice but not in fed<jats:italic>vs.<\/jats:italic> fasted mice with large or small tumor burdens. However, plasma FFA oxidation rates to CO<jats:sub>2<\/jats:sub> did not differ in briefly fasted tumor\u2010bearing and pairfed control mice. When re\u2010fed a 250\u2010mg test meal, briefly fasted mice with small tumors suppressed plasma free linoleic acid oxidation, as did controls. During simulated night, mildly anorexic, tumor\u2010bearing mice with small tumor burdens mobilized essential fatty acids much faster than controls. This could explain body fat loss. The abnormally rapid rates of FFA (free linoleic acid) mobilization at night probably result from anorexia rather than from inability of food to suppress fat mobilization.<\/jats:p>","DOI":"10.1007\/bf02535810","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T08:21:06Z","timestamp":1164788466000},"page":"117-123","source":"Crossref","is-referenced-by-count":0,"title":["Anorexic contribution to increased linoleate mobilization and oxidation in lymphoma\u2010bearing mice"],"prefix":"10.1002","volume":"27","author":[{"given":"Ram","family":"Kannan","sequence":"first","affiliation":[{"name":"Liver Research Laboratory, Medical Research Services Veterans Administration Wadsworth Medical Center Los Angeles California 90073"},{"name":"UCLA School of Medicine Los Angeles California 90024"},{"name":"Division of GI and Liver Diseases LAC\u2010USC Medical Center Los Angeles CA 90033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minerva","family":"Gan\u2010Elepano","sequence":"additional","affiliation":[{"name":"Liver Research Laboratory, Medical Research Services Veterans Administration Wadsworth Medical Center Los Angeles California 90073"},{"name":"UCLA School of Medicine Los Angeles California 90024"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nome","family":"Baker","sequence":"additional","affiliation":[{"name":"John Muir Cancer and Aging Research Institute 2055 North Broadway Walnut Creek CA 94596"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,2]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02540964"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240200410"},{"key":"e_1_2_2_4_1","first-page":"3106","volume":"48","author":"Sauer L.A.","year":"1988","journal-title":"Cancer Res."},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02544074"},{"key":"e_1_2_2_6_1","first-page":"2221","volume":"50","author":"Kannan R.","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_2_7_1","first-page":"1077","volume":"69","author":"Hays E.F.","year":"1982","journal-title":"J. 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