{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:21:15Z","timestamp":1771633275604,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1980,4,1]],"date-time":"1980-04-01T00:00:00Z","timestamp":323395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1980,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of oral administration of taurine (200\u2013300 mg daily) on the metabolism of bile acids was studied in male guinea pigs which have predominantly glycine conjugated bile acids. The results were summarized as follows: (a) oral administration of taurine for 10 days increased taurine\u2010conjugated bile acids and the ratio of glycine\u2010to taurine\u2010conjugated bile acids (G:T ratio) shifted from 3.95 to 0.19; (b) in taurine fed guinea pigs, the half\u2010life of chenodeoxycholic acid (CDC) was about 40% shorter than that in controls and the fractional turnover rate increased by 70%; (c) the synthetic rate (mg\/day\/500 g body weight) of bile acids increased from 4.28 to 7.27 by taurine feeding; (d) hepatic cholesterol 7\u03b1\u2010hydroxylase activity was increased 2.4\u2010fold by taurine feeding; (e) the total pool size of bile acids did not change significantly but the amount of lithocholic acid in the caecum and large intestine increased by about 40%; (f) neither free cholesterol nor cholesterol ester levels in liver and serum changed significantly. Results of this study suggest that changing the G:T ratio in the bile acid conjugation pattern may influence the rate of hepatic bile acid synthesis.<\/jats:p>","DOI":"10.1007\/bf02535831","type":"journal-article","created":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T01:53:46Z","timestamp":1165283626000},"page":"224-229","source":"Crossref","is-referenced-by-count":55,"title":["Effect of dietary taurine on bile acid metabolism in guinea pigs"],"prefix":"10.1002","volume":"15","author":[{"given":"Akihiro","family":"Kibe","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Sciences Hiroshima University, School of Medicine Kasumi 1\u20102\u20103 Hiroshima Japan"},{"name":"First Department of Surgery Kyushu University School of Medicine Maedashi 3\u20101\u20101 Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieko","family":"Wake","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences Hiroshima University, School of Medicine Kasumi 1\u20102\u20103 Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiju","family":"Kuramoto","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences Hiroshima University, School of Medicine Kasumi 1\u20102\u20103 Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Hoshita","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences Hiroshima University, School of Medicine Kasumi 1\u20102\u20103 Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1980,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)36863-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)93767-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-100-24741"},{"key":"e_1_2_1_5_1","first-page":"410","volume":"13","author":"Watkins J.B.","year":"1979","journal-title":"Pediatr. 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