{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:15:45Z","timestamp":1773814545119,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of dietary n\u22123 fatty acids on prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) and leukotriene C<jats:sub>4<\/jats:sub> (LTC<jats:sub>4<\/jats:sub>) levels in rat salivary glands and gingiva was examined in two separate nutritional studies. In the first set of experiments, two groups of male weanling Sprague\u2010Dawley rats were fed semipurified diets containing 10% corn oil (control group) or 10% menhaden oil (experimental group). Rats were killed after 8 wk on the diets; the fatty acid composition of total phospholipids and the concentrations of PGE<jats:sub>2<\/jats:sub> and its precursor, arachidonic acid, were measured in gingiva and submandibular salivary glands (SMSG). Dietary n\u22123 fatty acids were incorporated into the tissue phospholipids. Arachidonic acid levels were reduced by 56% in gingiva and SMSG of rats fed menhaden oil compared with the control rats fed the diet containing corn oil. The concentrations of PGE<jats:sub>2<\/jats:sub> in SMSG and gingiva of rats fed the diet containing menhaden oil were reduced by 74% and 83%, respectively. In a subsequent nutritional study, we tested whether the diet\u2010induced reduction in tissue arachidonic acid levels would also result in a corresponding decrease in LTC<jats:sub>4<\/jats:sub> production. Three groups of rats were fed diets containing 5% corn oil (group 1), 4% ethyl ester concentrate of n\u22123 fatty acids plus 1% corn oil (group 2), or 5% ethyl ester concentrate of n\u22123 fatty acids (group 3). After 6 wk of feeding, gingiva and SMSG were analyzed for arachidonic acid content and<jats:italic>in vitro<\/jats:italic> production of LTC<jats:sub>4<\/jats:sub>. Arachidonic acid content of total phospholipids was about 60% lower in gingiva and 69% lower in SMSG of rats fed the ethyl ester concentrate of n\u22123 fatty acids (groups 2 and 3) than those of the control group fed the corn oil diet (group 1). Upon incubation with calcium ionophore, gingiva and SMSG from rats fed the n\u22123 fatty acids rich diet produced significantly less TLC<jats:sub>4<\/jats:sub> than those from rats of the control group. Because PGE<jats:sub>2<\/jats:sub> and LTC<jats:sub>4<\/jats:sub> are believed to be important biochemical mediators of periodontal disease, one may speculate that a diet\u2010induced reduction in their levels may have a beneficial effect upon the course of the disease. The function of salivary glands may also be altered because of the role of these eicosanoids in salivary secretions.<\/jats:p>","DOI":"10.1007\/bf02535974","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T07:38:06Z","timestamp":1164785886000},"page":"895-900","source":"Crossref","is-referenced-by-count":42,"title":["Arachidonic acid, prostaglandin E<sub>2<\/sub> and leukotriene C<sub>4<\/sub> levels in gingiva and submandibular salivary glands of rats fed diets containing n\u22123 fatty acids"],"prefix":"10.1002","volume":"26","author":[{"given":"S. Q.","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology LSU Medical Center 1100 Florida Avenue New Orleans LA 70119"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M.","family":"Bergens","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology LSU Medical Center 1100 Florida Avenue New Orleans LA 70119"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. S.","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology LSU Medical Center 1100 Florida Avenue New Orleans LA 70119"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,11]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"13","volume-title":"Cell Membranes","author":"Chapman D.","year":"1975"},{"key":"e_1_2_2_3_1","first-page":"1","volume":"2","author":"Samuelsson B.","year":"1982","journal-title":"Prostaglandins and Related 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