{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:17:19Z","timestamp":1773425839502,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mice were fed diets with three different ratios of \u03b1\u2010linolenate (18\u2236\u22123) to linoleate (18\u22362n\u22126), and the severity of hepatitis during endotoxic shock was compared. Dietary enrichment with \u03b1\u2010linolenate increased the severity of hepatitis and the mortality induced by lipopolysaccharide (LPS) in combination with D\u2010galactosamine (GalN). Differences in the dietary \u03b1\u2010linolenate\/linoleate balance were mainly reflected in the levels of arachidonate and eicosapenatenoate in liver phospholipids. Pretreatement of mice with indomethacin was found to also enhance the severity of GalN\/LPS\u2010hepatitis. This indicated that cyclooxygenase products of arachidonate may suppress the development of GalN\/LPS\u2010hepatitis. The enhancement by high \u03b1\u2010linolenate diets was not observed when a lethal dose of LPS in the absence of GalN was given. Our results indicate that there are pathophysiological conditions of endotoxin\u2010induced hepatitis under which cyclooxygenase products of arachidonate play protective roles.<\/jats:p>","DOI":"10.1007\/bf02536074","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T06:12:36Z","timestamp":1164780756000},"page":"467-471","source":"Crossref","is-referenced-by-count":9,"title":["Effect of dietary \u03b1\u2010linolenate\/linoleate balance on endotoxin\u2010induced hepatitis in mice"],"prefix":"10.1002","volume":"26","author":[{"given":"Shiro","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, Faculty of Pharmaceutical Sciences Nagoya City University Mizuhoku, Nagoya Nagoya 467 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harumi","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Faculty of Pharmaceutical Sciences Nagoya City University Mizuhoku, Nagoya Nagoya 467 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,6]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"219","volume":"59","author":"Warner A.E.","year":"1988","journal-title":"Lab. 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