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The effect of 11\u2010deoxycorticosterone was mediated by a soluble protein present in the liver cytosolic fraction. The biological activity of this protein, having a molecular weight lower than 25 kDa, was impaired by trypsin digestion. To determine whether the inhibitory protein was induced through glucocorticoid or mineralocorticoid receptor occupancy, cultured Morris minimal deviation hepatoma cells were pre\u2010treated with the antiglucocorticoid cortexolone or the mineralocorticoid receptor antagonist spironolactone. The results obtained demonstrated that only glucocorticoid receptor structures were involved in the induction of this regulatory protein. The inhibitory response evoked by aldosterone was mediated by a different mechanism. In the case of aldosterone, the inhibitory action affected the microsomal membranes and was not mediated by a soluble protein messenger.<\/jats:p>","DOI":"10.1007\/bf02536117","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T10:41:01Z","timestamp":1164796861000},"page":"599-604","source":"Crossref","is-referenced-by-count":20,"title":["Glucocorticoid and mineralocorticoid hormones depress liver \u03945 desaturase activity through different mechanisms"],"prefix":"10.1002","volume":"27","author":[{"given":"Maria J. 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