{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:45:27Z","timestamp":1778543127906,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[1991,10,1]],"date-time":"1991-10-01T00:00:00Z","timestamp":686275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lipids"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of hypothyroidism and of daily treatment for up to 21 days with thyroxin (T4, 0.5 \u03bcg\/100 g body weight) on the fatty acid composition of total lipid, phosphatidylethanolamine, and phosphatidylcholine of rat liver mitochondria were studied. The fatty acid compositions of hypothyroid and euthyroid (control) rats of similar age were compared. The n\u22126 and n\u22123 polyunsaturated fatty acids (PUFA) were affected differently by the hypothyroid state. The levels of linoleic (18\u22362n\u22126), \u03b3\u2010linolenic (18\u22363n\u22126) and dihomo\u2010\u03b3\u2010linolenic acids (20\u22363n\u22126) were higher in hypothyroid rats than in controls, while the level of arachidonic acid (20\u22364n\u22126) was lower, which suggests an impairment of the elongase and desaturase activities. The n\u22123 polyunsaturated fatty acids, eicosapentaenoic (EPA, 20\u22365n\u22123) and docosapentaenoic (22\u22365n\u22123) acids, were higher in hypothyroid rats, whereas the linolenic acid (18\u22363n\u22123) content remained constant. The level of docosahexaenoic acid (DHA, 22\u22366n\u22123) was dramatically decreased in hypothyroid rats, while the levels of C<jats:sub>22<\/jats:sub> n\u22126 fatty acids were unchanged. The differences were probably due to the competition between n\u22123 and n\u22126 PUFA for desaturases, elongases and acyltransferases. When hypothyroid rats were treated with thyroxin, the changes induced by hypothyroidism in the proportions of n\u22126 fatty acids were rapidly reversed, while the changes in the n\u22123 fatty acids were only partially reversed. After 21 days of thyroxin treatments, the DHA content was only half as high in hypothyroid rats than in euthyroid rats. These results suggest that the conversion of 18\u22362n\u22126 to 20\u22364n\u22126 is suppressed in the hypothyroid state which favors the transformation of 18\u22363n\u22123 to 20\u22365n\u22123. The marked decrease in DHA content indicates an impairment of the enzymes involved in the DHA metabolism, possibly the n\u22123 \u03944 desaturase or the acyltransferases. The increased levels of EPA and 22\u22365n\u22123 is consistent with the inhibition of the n\u22123 pathway at the \u03944 desaturase step. Observed modifications in the fatty acid composition may significantly alter eicosanoid synthesis and membrane functions in hypothyroidism.<\/jats:p>","DOI":"10.1007\/bf02536158","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T07:28:43Z","timestamp":1164785323000},"page":"781-787","source":"Crossref","is-referenced-by-count":34,"title":["Hypothyroidism and thyroxin substitution affect the n\u22123 fatty acid composition of rat liver mitochondria"],"prefix":"10.1002","volume":"26","author":[{"given":"D.","family":"Raederstorff","sequence":"first","affiliation":[{"name":"Department of Vitamin and Nutrition Research F. Hoffmann\u2010La Roche Ltd. VFRB B. 60\/317A Basel CH\u20104002 Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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